ChemicalBook >> CAS DataBase List >>4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Structure](CAS/GIF/119018-29-0.gif)
- CAS No.
- 119018-29-0
- Chemical Name:
- 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
- Synonyms
- Glimepiride sulfonamide;4-ethyl-3-methyl-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-pyrrole-1-carboxamide;4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benezenesulfonamide;N -{2-[4-(aminosulfonyl) phenyl] ethyl}- 3-ethyl-4methyl-2-oxo-2,5- dihydro-1H-pyrrole-1- carboxamide;GLMN-C;Glimepiride imp B;Glemyurea impurity B;GLIMEPIRIDE EP IMP B;Glimepiride impurity2;GliMepiride IMpurity B
- CBNumber:
- CB3156704
- Molecular Formula:
- C16H21N3O4S
- Molecular Weight:
- 351.42
- MDL Number:
- MFCD02955393
- MOL File:
- 119018-29-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 01:01:51
| Product description | Number | Pack Size | Price |
| Glimepiride Sulfonamide pharmaceutical secondary standard, certified reference material | PHR1726 | 40 mg | $712 |
| Glimepiride Related Compound B | 1292325 | 20mg | $1290 |
| 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide >95%(HPLC) | TRC-E925045-25MG | 25mg | $195 |
| 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide >95%(HPLC) | TRC-E925045-250MG | 250mg | $872 |
| 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide >95%(HPLC) | TRC-E925045-100MG | 100mg | $624 |
| More product size | |||
| Melting point | 177-179C |
|---|---|
| Density | 1.304 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 10.16±0.10(Predicted) |
| color | White to Off-White |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C16H21N3O4S/c1-3-14-11(2)10-19(15(14)20)16(21)18-9-8-12-4-6-13(7-5-12)24(17,22)23/h4-7H,3,8-10H2,1-2H3,(H,18,21)(H2,17,22,23) |
| InChIKey | AJEMFZRCUKJSES-UHFFFAOYSA-N |
| SMILES | N1(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)CC(C)=C(CC)C1=O |
| CAS DataBase Reference | 119018-29-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 612913U5L6 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 52/53 |
| Safety Statements | 61 |
| WGK Germany | WGK 1 |
| HS Code | 2935909550 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 3 |
| REACH Registrations | Active |
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1726 | Glimepiride Sulfonamide pharmaceutical secondary standard, certified reference material | 119018-29-0 | 40 mg | $712 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1292325 | Glimepiride Related Compound B | 119018-29-0 | 20mg | $1290 | 2026-04-30 | Buy |
| TRC | TRC-E925045-25MG | 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide >95%(HPLC) | 119018-29-0 | 25mg | $195 | 2026-06-03 | Buy |
| TRC | TRC-E925045-250MG | 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide >95%(HPLC) | 119018-29-0 | 250mg | $872 | 2026-06-03 | Buy |
| TRC | TRC-E925045-100MG | 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide >95%(HPLC) | 119018-29-0 | 100mg | $624 | 2026-06-03 | Buy |
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide (Glimepiride EP Impurity B) is an intermediate for the preparation of Glimepiride.
Synthesis
![4-{2-{[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)-carbonyl]-amino}-ethyl}-benzenesulfonyl chloride](/CAS/GIF/119043-16-2.gif)
119043-16-2
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide](/CAS/GIF/119018-29-0.gif)
119018-29-0
38.0 kg of methanol and 5.1 kg of industrial ammonia were sequentially added to a 100 L reactor and stirring was initiated. The crude wet product of Intermediate 2 was added slowly at 20-30°C and the reaction was maintained for 2 hours. The progress of the reaction was monitored by HPLC and after the reaction was complete, filtration was carried out and the filter cake was washed with deionized water. The obtained crude wet product of white Intermediate 3 was directly transferred to a 200 L reactor. Subsequently, 110.0 kg of methanol was added, the reaction temperature was raised and stirring was continued for 4 hours. After completion of the reaction, the mixture was cooled to 20-25 °C, the product was separated by filtration and dried to obtain 8.47 kg of white solid Intermediate 3 refined product, with purity >99% and interstitial isomer impurity content of 0.2% by HPLC.
References
[1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855
[2] Patent: WO2006/103690, 2006, A1. Location in patent: Page/Page column 7,14-15
[3] Patent: CN108383768, 2018, A. Location in patent: Paragraph 0101; 0102
Synthesis of 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide from 4-{2-{[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)-carbonyl]-amino}-ethyl}-benzenesulfonyl chloride
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 261)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide pictures](/ProductImageEN/2021-09/Small/afc94d96-db80-4362-a6a5-3cea90e14952.jpg) |
2026-07-27 | 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
119018-29-0
|
1KG | 99%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide pictures](/ProductImageEN1/2025-04/Small/1a810a0a-26c3-49dc-96d3-0286bdd965da.gif) |
2026-06-30 | 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
119018-29-0
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide pictures](/ProductImageEN1/2025-05/Small/ed02413d-f88d-464e-a2be-eb3a896cfbf5.png) |
2026-06-30 | 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
119018-29-0
|
1kg | 98% | 10000kgs | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
119018-29-0
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
119018-29-0
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
119018-29-0
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
119018-29-0(4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide)Related Search:
n-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-1h-pyrrole-1-carboxamide
N-[2-[4-(AMINOSULFONYL)PHENYL]ETHYL]-3-ETHYL-4-METHYL-2-OXO-1H-PYRROLE-1-CARBOXAMIDE
4-(2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl)-Benzenesulfonyl A
4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamidoethyl]benzenesulfonamide
N-[4-2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl]Benzensulfonamide
SulfonamideofGlimepiride
4-[2-(3-ETHYL-4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMINDO)ETHYL]BENZENESULFONAMIDE
3-Ethyl-2,5-dihydro-4-methyl-N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-oxo-1H-pyrrole--1-carboxamide
3-ETHYL-4-METHYL-2-OXO-N-(2-(P-AMINOSULFONYLPHENYL)ETHYL)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE
N-[2-[4-(AMINOSULFONYL)PHENYL]-3-ETHYL-2,5-DIHYDRO-4-METHYL-2-OXO]-1H-PYRROLE-1-CARBOXAMIDE
Des[(trans-4-methylcyclohexyl)amino]carbonyl Glimepiride
4-(2-((3-ethyl-4-methyl-2-oxo-pyrrolin-1-yl)carboxamido)ethyl)benzenesulfonamide)
Glimepiride Related Compound B (20 mg) (glimepiride sulfonamide)
4-[2-(3-ETHYL-4-METHYL-2-OXO-3-PYROLIDINE-1-CARBOXAMIDO) ETHYL]BENZENE SULPHONAMIDE
GliMepiride EP IMpurity B
4-[2-(3-ethyl-4-Methyl-2-oxo-pyrroline-1-carboxaMido)-ethyl] Benzene sulfonaMide
GliMepiride IMpurity B
1H-Pyrrole-1-carboxaMide,N-[2-[4-(aMinosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-Methyl-2-oxo-
Glimepiride Related Compound B (20 mg) (glimepiride sulfonamide, or 3-Ethyl-4-methyl-2-oxo-N-(4-sulfamoylphenethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide)
4-(2-(3-ETHYLMETHYL-2-CARBONYLPYRROLIDINYLAMINO)ETHYL)BENZENESULFONAMIDE
4-[2-(3-ethyl-4-methyl-2-oxy-3-pyrrolinyl-1-methylamide)benzene sulfonamide]
GliMepiride Related CoMpound B
Glimepiride impurity2
4-(2-(3-ethyl-4-methyl-2-oxo-pyrroline-1-carboxamido)-ethyl))
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
4-[2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamide)Ethyl]Sulphonamide
Glimepiride Impurity 2(Glimepiride EP Impurity B)
GLIMEPIRIDE SULPHONAMIDE (4-(2-(3-ETHYL- 4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMIDE )ETHYL)BENZENESULPHONAMIDE (OTHER)
Glimepiride imp B
GLIMEPIRIDE SULPHONAMIDE (4-(2-(3-ETHYL- 4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMIDE )ETHYL)BENZENESULPHONAMIDE
3-ETHYL-4-METHYL-2-OXO-N-(2-(P-AMINOSULFONYLPHENYL)ETHYL)-2,5-DIHYDRO-1H-PYRROLE-1-
Glimepiride impurityⅢ{4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl] Benzene sulfonamide}
3-Ethyl-4-methyl-2-oxo-N-[2-(4-sulp
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide/Glimepiride Impurity B
4-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-2-carboxamide)ethyl)Benzene sulfonamide
GLMN-C
4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrrolin-1)carboxamido]ethyl]benzene sulfonamide
Glimepiride EP Impurity B/ Glimepiride Related Compound B (Glimepiride Sulfonamide)
Glimepiride Sulphonamide
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrroline)carboxamido]ethyl]...
Glimepiride Related Compound B (1292325)
Glimepiride Related Compound B (glimepiride sulfonamide, or 3-Ethyl-4-methyl-2-oxo-N-(4-sulfamoylph (1292325)
Glimepiride impurityⅢ
{4-[2-(3-ethyl-4-methyl-2-oxo- 3-pyrroline-1-carboxamido)-eth yl] Benzene sulfonamide}
Glimepiride USP Related Compound B
3-ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2,3-dihydro-1H-pyrrole-1-carboxamide
Glemyurea impurity B
EP IMPURITY-B/GLIMEPIRIDE SULFOMIDE
4- [2- (3-ethyl-4-methyl-2-oxo-3-pyrroline-1-formamido) ethyl] - benzenesulfonamide
Glimeperide sulfonamide
3-ethyl-4-methyl-2-oxo-N-[2-(3-sulfamoylphenyl) ethyl]-2,5-dihydro-1H-pyrrole-1-carboxamide
N-{4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline)-1-carboxamido]ethyl} phenyl sulfonamide
Glimipiride imp B / Glimepiride Related Compound B
Sulphonamide of Glimipride
GLIMEPIRIDE EP IMP B
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide , Glimepiride sulfonamide
N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4- methyl-2-oxo-1H-pyrrole-1-carboxamide [Sulphonamide]
Glimepiride EP Impurity B
USP Glimepiride Related Compound B
Glimepiride EP Impurity B/USP Related Compound B
