Polyinosinic acid-polycytidylic acid
- CAS No.
- 24939-03-5
- Chemical Name:
- Polyinosinic acid-polycytidylic acid
- Synonyms
- polyi:c;Polyinosinic;polyi-c;Poly-Na;poly(i+c);Poly I:Cr;nsc-120949;polycpolyi;poly(ri:rc);polyri:polyrc
- CBNumber:
- CB3181814
- Molecular Formula:
- C19H27N7O16P2
- Molecular Weight:
- 671.41
- MDL Number:
- MFCD00131957
- MOL File:
- 24939-03-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | OP29952 | 2g | $240.26 |
| Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | OP29952 | 5g | $384.3 |
| Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | OP29952 | 10g | $615 |
| Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | OP29952 | 25g | $1345 |
| Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | OP29952 | 50g | $2412.5 |
| More product size | |||
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble to 3 mg/ml in water |
| Stability | Hygroscopic |
| InChIKey | ACEVNMQDUCOKHT-WOQDZEJINA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r| |
| EWG's Food Scores | 1 |
| FDA UNII |
POLYINOSINIC-POLYCYTIDYLIC ACID (LOW MW) (3R630IWW5I) POLYINOSINIC-POLYCYTIDYLIC ACID (HIGH MW) (O84C90HH2L) |
| NCI Drug Dictionary | poly IC |
| ATC code | L03AX07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H402 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | TR0175000 |
Polyinosinic acid-polycytidylic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | OP29952 | Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | 24939-03-5 | 2g | $240.26 | 2026-06-04 | Buy |
| Biosynth | OP29952 | Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | 24939-03-5 | 5g | $384.3 | 2026-06-04 | Buy |
| Biosynth | OP29952 | Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | 24939-03-5 | 10g | $615 | 2026-06-04 | Buy |
| Biosynth | OP29952 | Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | 24939-03-5 | 25g | $1345 | 2026-06-04 | Buy |
| Biosynth | OP29952 | Polyinosinic acid-polycytidylic acid, homopolymer (1:1) | 24939-03-5 | 50g | $2412.5 | 2026-06-04 | Buy |
Polyinosinic acid-polycytidylic acid Chemical Properties,Uses,Production
Uses
Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.
Definition
ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Biological Activity
poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923.
in vivo
Polyinosinic-polycytidylic acid (2.5-10 mg/mL, Stereotaxic injection, single dose) induces a sustained inflammatory reaction in the substantia nigra (SN) and in the dorsolateral striatum. [2].
Polyinosinic-polycytidylic acid (10 μg/mouse, Intraperitoneal injection, single dose) decreases lung tumor growth in mice[3].
Polyinosinic-polycytidylic acid (1.25 mg/kg, Intraperitoneal injection, single dose) exerts therapeutic effects against cerebral I/R injury through the downregulation of TLR4/MyD88 signaling via TLR3 in MCAO model mice[5].
| Animal Model: | lung tumor-bearing mice[3] |
| Dosage: | 10 μg/mouse |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Induced a significant decrease in the growth of pulmonary metastases in tumor-bearing mice. Reduced the amount of lung foci to ≈ 40%. Significantly increased BAL fluid cell numbers. Increased the level of INF-γ and IL-17A, decreased the levels of IL-13. Increased TLR3 expression. |
| Animal Model: | Middle cerebral artery occlusion (MCAO) model mice[5] |
| Dosage: | 1.25 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced focal cerebral I/R injury. Increased the expression of Bcl2, Hsp27, and Hsp70, decreased Bax expression, and reduced cellular degeneration and apoptosis. Protected against cerebral ischemia and conferred protection against cerebral I/R injury through the downregulation of TLR4 signaling via TLR3. |
IC 50
Bcl-2; Bax; IL-17A; IL-13; HSP70
Polyinosinic acid-polycytidylic acid Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | doris@njduly.com | China | 2448 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055326116 | sales1@nuowei-chem.com | China | 1627 | 58 |
| Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +86-18001850931 | wangjm@meiyapharm.com | China | 58 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5983 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
Related articles
- Bioactivity of Therapeutic Uses of Polyinosinic acid-polycytidylic acid
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- Dec 8，2025
View Lastest Price from Polyinosinic acid-polycytidylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-12 | Polyinosinic acid-polycytidylic acid
24939-03-5
|
1kg | 98% | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-06-11 | Polyinosinic-polycytidylic acid
24939-03-5
|
$45.00-148.00 | 90.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-02 | Polyinosinic-polycytidylic acid sodium salt (PIC)
24939-03-5
|
1kg | ≥90.0% | 10 tons | Hangzhou Meiya Pharmaceutical Co Ltd |
-
- Polyinosinic acid-polycytidylic acid
24939-03-5
- 98%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Polyinosinic-polycytidylic acid
24939-03-5
- $45.00-148.00
- 90.00%
- TargetMol Chemicals Inc.
-
- Polyinosinic-polycytidylic acid sodium salt (PIC)
24939-03-5
- ≥90.0%
- Hangzhou Meiya Pharmaceutical Co Ltd
