ZAPRINAST
- CAS No.
- 37762-06-4
- Chemical Name:
- ZAPRINAST
- Synonyms
- ZAPRINAST;M&B 22,948;M AND B 22948;M-EPSILON-TB22948;Phenylaza purinon;ZAPRINAST USP/EP/BP;Zaprinast (M&B 22948);Zaprinast, 10 mM in DMSO;3,6-dihydro-5-(2-propoxyphenyl)-;2-(o-Propoxyphenyl)-8-azapurin-6-one
- CBNumber:
- CB3215496
- Molecular Formula:
- C13H13N5O2
- Molecular Weight:
- 271.27
- MDL Number:
- MFCD00214073
- MOL File:
- 37762-06-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Zaprinast solid | Z0878 | 25mg | $114 |
| Zaprinast ≥98% | 10010421 | 10mg | $31 |
| Zaprinast ≥98% | 10010421 | 50mg | $129 |
| Zaprinast ≥98% | 10010421 | 100mg | $228 |
| Zaprinast ≥98% | 10010421 | 250mg | $493 |
| More product size | |||
| Melting point | 237-238°C dec. |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| RTECS | XZ6157358 |
| storage temp. | Store at RT |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL |
| form | solid |
| pka | 6.92±0.20(Predicted) |
| color | white |
| Water Solubility |
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11mg/mL DMSO: 10mg/mL H2O: insoluble |
| InChI | 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) |
| InChIKey | REZGGXNDEMKIQB-UHFFFAOYSA-N |
| SMILES | CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2 |
| CAS DataBase Reference | 37762-06-4 |
| FDA UNII | GXT25D5DS0 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
ZAPRINAST price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z0878 | Zaprinast solid | 37762-06-4 | 25mg | $114 | 2026-04-30 | Buy |
| Cayman Chemical | 10010421 | Zaprinast ≥98% | 37762-06-4 | 10mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 10010421 | Zaprinast ≥98% | 37762-06-4 | 50mg | $129 | 2026-04-30 | Buy |
| Cayman Chemical | 10010421 | Zaprinast ≥98% | 37762-06-4 | 100mg | $228 | 2026-04-30 | Buy |
| Cayman Chemical | 10010421 | Zaprinast ≥98% | 37762-06-4 | 250mg | $493 | 2026-04-30 | Buy |
ZAPRINAST Chemical Properties,Uses,Production
Description
The cyclic nucleotide second messenger guanosine 3’5’-
Chemical Properties
Zaprinast is Yellow-Orange Crystalline Powder
Uses
Zaprinast is a selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of at rial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.
Uses
cGMP phosphodiesterase inhibitor
Uses
Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.
Definition
ChEBI: 5-(2-propoxyphenyl)-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one is a member of triazolopyrimidines.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively).
Biochem/physiol Actions
Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.
in vitro
zaprinast is a pde5 and pde6 inhibitor with inhibiting pde9 at moderately high concentrations (29 mm) [1]. indeed, it showed that inhibition of cgmp hydrolysis by infusion of zaprinast increases the effect of anp on natriuresis with no causing deleterious drops in blood pressure. because it was known that anp receptors is localized within the glomerulus and inner medullary collecting ducts, to determine the cellular localization of pde9 enzyme in kidney will be interesting. [2]. the enzyme displayed a high specificity for cgmp with binding sites for cgmp, and a sensitivity to zaprinast similar to smooth muscle pde5, resulting in both enzymes were named cgmp-pde. however, retinal cgmp-pde was first distinguished as photoreceptor cgmp-pde with being specifically distributed in the retina and having a higher vmax and km values than other cgmp-pdes and being modulated by g protein. [3].
IC 50
0.15, 0.76, 12.0 and 29.0 μm for pde6, 5, 11 and 9 respectively.
storage
Store at RT
References
[1] christensen and torphy (1994) isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. annu.rep.med.chem. 29 185.
[2] soderling sh, bayuga sj, beavo ja. identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. j biol chem. 1998 jun 19; 273(25):15553-8.
[3]. lugnier c. cyclic nucleotide phosphodiesterase (pde) superfamily: a new target for the development of specific therapeutic agents. pharmacol ther. 2006 mar; 109 (3):366-98. epub 2005 aug 15.
ZAPRINAST Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29119 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +86-13382787392 | sales@aeechem.com | China | 10002 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9658 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4764 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
View Lastest Price from ZAPRINAST manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Zaprinast
37762-06-4
|
$29.00 | 99.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-18 | ZAPRINAST USP/EP/BP
37762-06-4
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Zaprinast
37762-06-4
- $29.00
- 99.77%
- TargetMol Chemicals Inc.
-
- ZAPRINAST USP/EP/BP
37762-06-4
- $1.10
- 99.9%
- Dideu Industries Group Limited
