1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- CAS No.
- 287193-00-4
- Chemical Name:
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- Synonyms
- tert-butyl 3-ethynylpyrrolidine-1-carboxylate;1-Boc-3-ethynylpyrrolidine;1-Boc-3-ethynylpyrrolidin...;acid, 3-ethynyl-, 1,1-dimethylethyl ester;tert-Butyl 3-ethynyl-1-pyrrolidinecarboxylate;1,1-Dimethylethyl 3-ethynyl-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester;3-ethynyl-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester - [P7677]
- CBNumber:
- CB32473670
- Molecular Formula:
- C11H17NO2
- Molecular Weight:
- 195.26
- MDL Number:
- MFCD10698160
- MOL File:
- 287193-00-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Boc-3-ethynylpyrrolidine | 112402 | 250.00mg | $59 |
| 1-Boc-3-ethynylpyrrolidine | 112402 | 1.00g | $90 |
| 1-Boc-3-ethynylpyrrolidine | 112402 | 5.00g | $139 |
| 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester 97.0% | P7677 | 250mg | $61 |
| 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester 97.0% | P7677 | 1g | $100 |
| More product size | |||
| Boiling point | 249.2±29.0 °C(Predicted) |
|---|---|
| Density | 1.04±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | -2.53±0.40(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | 0.9898°(C=0.1566g/100ml MEOH) |
| InChI | 1S/C11H17NO2/c1-5-9-6-7-12(8-9)10(13)14-11(2,3)4/h1,9H,6-8H2,2-4H3 |
| InChIKey | KTDGOUSDBBFBRO-UHFFFAOYSA-N |
| SMILES | CC(C)(OC(N1CCC(C#C)C1)=O)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 112402 | 1-Boc-3-ethynylpyrrolidine | 287193-00-4 | 250.00mg | $59 | 2026-05-18 | Buy |
| Matrix Scientific | 112402 | 1-Boc-3-ethynylpyrrolidine | 287193-00-4 | 1.00g | $90 | 2026-05-18 | Buy |
| Matrix Scientific | 112402 | 1-Boc-3-ethynylpyrrolidine | 287193-00-4 | 5.00g | $139 | 2026-05-18 | Buy |
| Synthonix | P7677 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester 97.0% | 287193-00-4 | 250mg | $61 | 2026-05-06 | Buy |
| Synthonix | P7677 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester 97.0% | 287193-00-4 | 1g | $100 | 2026-05-06 | Buy |
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Chemical Properties,Uses,Production
Application
tert-butyl 3-ethynylpyrrolidine-1-carboxylate is a useful research chemical.
Synthesis
90965-06-3
59379-02-1
287193-00-4
GENERAL STEPS: 1-Boc-3-pyrrolidinecarboxaldehyde (580 mg, 2.91 mmol) was dissolved in methanol (15 mL) at room temperature, and potassium carbonate (1.00 g, 7.28 mmol) and dimethyl (1-diazido-2-oxopropyl)phosphonate (839 mg, 4.37 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, it was filtered through a short diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with an eluent gradient of 0 to 50% ethyl acetate/hexane to give a colorless oily product. The product was allowed to stand in a refrigerator and cured to give 1-Boc-3-ynylpyrrolidine white solid (374 mg, 66% yield).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 18, p. 8417 - 8443
[2] Patent: US2016/9720, 2016, A1. Location in patent: Paragraph 0250
[3] Patent: US2016/9711, 2016, A1. Location in patent: Paragraph 0242; 0243; 0244
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9553 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9333 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-15 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
- $9.80
- ≥99%
- Career Henan Chemical Co
