3-Nitro-4-(trifluoromethoxyl)benzoic acid
- CAS No.
- 784-77-0
- Chemical Name:
- 3-Nitro-4-(trifluoromethoxyl)benzoic acid
- Synonyms
- 3-Nitro-4-(trifluoromethoxy)benzoic acid;3-Nitro-4-(trifluoromethoxyl)benzoic acid;3-Nitro-4-(trifluoromethoxy)benzoicacid99%;Benzoic acid, 3-nitro-4-(trifluoromethoxy)-;alpha,alpha,alpha-Trifluoro-3-nitro-p-anisic acid
- CBNumber:
- CB32502570
- Molecular Formula:
- C8H4F3NO5
- Molecular Weight:
- 251.12
- MDL Number:
- MFCD13185757
- MOL File:
- 784-77-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | PC408277 | 5g | $21 |
| 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | PC408277 | 25g | $41 |
| 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | PC408277 | 100g | $130 |
| 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | PC408277 | 5g | $21 |
| 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | PC408277 | 25g | $41 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 2922498590 |
3-Nitro-4-(trifluoromethoxyl)benzoic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC408277 | 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | 784-77-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC408277 | 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | 784-77-0 | 25g | $41 | 2026-06-04 | Buy |
| Apolloscientific | PC408277 | 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | 784-77-0 | 100g | $130 | 2026-06-04 | Buy |
| Apolloscientific | PC408277 | 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | 784-77-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC408277 | 3-Nitro-4-(trifluoromethoxy)benzoic acid 99% | 784-77-0 | 25g | $41 | 2026-06-04 | Buy |
3-Nitro-4-(trifluoromethoxyl)benzoic acid Chemical Properties,Uses,Production
Chemical Properties
off-white powder
Synthesis
330-12-1
784-77-0
Step 1: Synthesis of 3-nitro-4-(trifluoromethoxy)benzoic acid 4-(Trifluoromethoxy)benzoic acid (900 mg, 4.37 mmol) was dissolved in concentrated hydrochloric acid. Concentrated sulfuric acid (9 mL) was cooled at 0 °C and a concentrated sulfuric acid (4.5 mL) solution of potassium nitrate (486 mg, 4.80 mmol) was slowly added. The reaction temperature was maintained at 0°C with continuous stirring for 2 hours. After completion of the reaction, the mixture was poured into water (50 mL) and extracted with ethyl acetate (150 mL). The organic phase was washed sequentially with brine (2 x 100 mL), dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure to afford the crude product 3-nitro-4-(trifluoromethoxy)benzoic acid (1.05 g, 4.18 mmol, 96% yield, MS/ESI+ m/z 252.1 [M+H]+). The crude product can be used directly in the next reaction without further purification.
References
[1] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0651; 0652
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 21, p. 5995 - 6006
[3] Patent: US6268387, 2001, B1
[4] Patent: WO2007/31791, 2007, A1. Location in patent: Page/Page column 137
[5] Patent: WO2008/59214, 2008, A1. Location in patent: Page/Page column 147-148
3-Nitro-4-(trifluoromethoxyl)benzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9796 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
View Lastest Price from 3-Nitro-4-(trifluoromethoxyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-26 | 3-Nitro-4-(trifluoromethoxyl)benzoic acid
784-77-0
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
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- 3-Nitro-4-(trifluoromethoxyl)benzoic acid
784-77-0
- $1.00
- 99%
- Career Henan Chemical Co
