SRT2104 (GSK2245840)
- CAS No.
- 1093403-33-8
- Chemical Name:
- SRT2104 (GSK2245840)
- Synonyms
- CS-2293;GSK2245840;SRT-2104;SRT 2104;sirtuin Modulator;SRT2104 (GSK2245840);SRT 2104, 10 mM in DMSO;SRT2104 (GSK2245840) ，S7792;SRT2104 (GSK2245840) USP/EP/BP;SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit;(E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID
- CBNumber:
- CB32624034
- Molecular Formula:
- C26H24N6O2S2
- Molecular Weight:
- 516.64
- MDL Number:
- MFCD22572733
- MOL File:
- 1093403-33-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SRT2104 ≥98% (HPLC) | SML3754 | 5 mg | $143 |
| SRT2104 ≥98% (HPLC) | SML3754 | 25 mg | $574 |
| SRT 2104 ≥98% | 28380 | 1mg | $49 |
| SRT 2104 ≥98% | 28380 | 5mg | $190 |
| SRT 2104 ≥98% | 28380 | 10mg | $329 |
| More product size | |||
| Density | 1.46±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥6.46 mg/mL in DMSO with gentle warming |
| form | Powder |
| pka | 11.40±0.70(Predicted) |
| color | Light yellow to yellow |
| InChIKey | LAMQVIQMVKWXOC-UHFFFAOYSA-N |
| SMILES | S1C(C(NC2=CC=CC=C2C2=CN3C(CN4CCOCC4)=CSC3=N2)=O)=C(C)N=C1C1=CC=CN=C1 |
| FDA UNII | 4521NR0J09 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
SRT2104 (GSK2245840) price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3754 | SRT2104 ≥98% (HPLC) | 1093403-33-8 | 5 mg | $143 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3754 | SRT2104 ≥98% (HPLC) | 1093403-33-8 | 25 mg | $574 | 2026-04-30 | Buy |
| Cayman Chemical | 28380 | SRT 2104 ≥98% | 1093403-33-8 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 28380 | SRT 2104 ≥98% | 1093403-33-8 | 5mg | $190 | 2026-04-30 | Buy |
| Cayman Chemical | 28380 | SRT 2104 ≥98% | 1093403-33-8 | 10mg | $329 | 2026-04-30 | Buy |
SRT2104 (GSK2245840) Chemical Properties,Uses,Production
Uses
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease[1][2][3].
Biological Activity
srt2104 (gsk2245840) is a selective sirt1 activator involved in the regulation of energy homeostasis. sirt1, also known as nad-dependent deacetylase sirtuin-1, is a member of the sirtuin family of proteins.
in vitro
in c2c12 myoblasts stably transfected with small hairpin rna to knock-down sirt1, srt2104 increased ap activity, a marker for osteogenic differentiation. this effect was totally dependent on sirt1 expression [1].
in vivo
in male c57bl/6j mice, administration of srt2104 (100 mg/kg, p.o.) extended both mean and maximal lifespan of mice fed a standard diet, and enhanced bone mineral density, motor coordination, and insulin sensitivity and decreased inflammation. short-term srt2104 administration preserved bone and muscle mass in an experimental model of atrophy [1]. in male n171-82q hd mice with huntington's disease, srt2104 (diet containing 0.5% srt2104) effectively penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and extended survival [2].
IC 50
SIRT1
References
[1]. mercken e m, mitchell s j, martin‐montalvo a, et al. srt2104 extends survival of male mice on a standard diet and preserves bone and muscle mass[j]. aging cell, 2014, 13(5): 787-796.
[2]. jiang m, zheng j, peng q, et al. sirtuin 1 activator srt2104 protects huntington's disease mice[j]. annals of clinical and translational neurology, 2014, 1(12): 1047-1052.
SRT2104 (GSK2245840) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9547 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-86-15536356810 +8617392712697 | 1022@dideu.com | China | 28760 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
