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ChemicalBook >> CAS DataBase List >>2-Chloro-3-nitro-4-pyridinecarboxylic acid

2-Chloro-3-nitro-4-pyridinecarboxylic acid

CAS No.
353281-15-9
Chemical Name:
2-Chloro-3-nitro-4-pyridinecarboxylic acid
Synonyms
2-Chloro-3-nitropyridine-4-carboxylic acid;2-Chloro-3-nitro-4-pyridinecarboxylic acid
CBNumber:
CB32652837
Molecular Formula:
C6H3ClN2O4
Molecular Weight:
202.55
MDL Number:
MFCD01928336
MOL File:
353281-15-9.mol
MSDS File:
SDS
Last updated:2026-05-28 01:09:38
Product description Number Pack Size Price
2-Chloro-3-nitropyridine-4-carboxylic acid DPA28115 25g $590
2-Chloro-3-nitropyridine-4-carboxylic acid 122268 5.00g $44
2-Chloro-3-nitropyridine-4-carboxylic acid 122268 25.00g $196
2-Chloro-3-nitropyridine-4-carboxylic acid 122268 100.00g $789
2-Chloro-3-nitropyridine-4-carboxylic acid 97.0% C10710 1g $23
More product size

2-Chloro-3-nitro-4-pyridinecarboxylic acid Properties

Boiling point 484.7±45.0 °C(Predicted)
Density 1.702±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 1.01±0.25(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-Chloro-3-nitro-4-pyridinecarboxylic acid price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth DPA28115 2-Chloro-3-nitropyridine-4-carboxylic acid 353281-15-9 25g $590 2026-06-04 Buy
Matrix Scientific 122268 2-Chloro-3-nitropyridine-4-carboxylic acid 353281-15-9 5.00g $44 2026-05-18 Buy
Matrix Scientific 122268 2-Chloro-3-nitropyridine-4-carboxylic acid 353281-15-9 25.00g $196 2026-05-18 Buy
Matrix Scientific 122268 2-Chloro-3-nitropyridine-4-carboxylic acid 353281-15-9 100.00g $789 2026-05-18 Buy
Synthonix C10710 2-Chloro-3-nitropyridine-4-carboxylic acid 97.0% 353281-15-9 1g $23 2026-05-06 Buy
Product number Packaging Price Buy
DPA28115 25g $590 Buy
122268 5.00g $44 Buy
122268 25.00g $196 Buy
122268 100.00g $789 Buy
C10710 1g $23 Buy

2-Chloro-3-nitro-4-pyridinecarboxylic acid Chemical Properties,Uses,Production

Synthesis

2-Chloro-4-methyl-3-nitropyridine

23056-39-5

2-Chloro-3-nitro-4-pyridinecarboxylic acid

353281-15-9

General procedure for the synthesis of 2-chloro-3-nitro-4-pyridinecarboxylic acid from 2-chloro-4-methyl-3-nitropyridine: 2-chloro-4-methyl-3-nitropyridine (4.00 g, 23.00 mmol) was dissolved in sulphuric acid (40 ml) at 0 °C and potassium dichromate (8.85 g, 30.00 mmol) was added in batches. The reaction mixture was heated and stirred at 60°C for 8 hours. After completion of the reaction, the mixture was allowed to cool to room temperature and slowly poured into ice water. Multiple extractions were carried out with ethyl acetate (5 x 30 ml). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was ground with pentane (3 × 5 ml) to afford 2-chloro-3-nitro-4-pyridinecarboxylic acid (4.00 g, 19.70 mmol), which was used for subsequent reactions without further purification.LCMS analysis (Method C): 1.51 min; mass spectrometry (MS): ESI m/z 201.1 [M-1 ]; 1H NMR (400 MHz. DMSO-d6) δ 8.83 (d, J = 5Hz, 1H), 8.03 (d, J = 5Hz, 1H).

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 7-8
[2] Patent: US2016/333009, 2016, A1. Location in patent: Paragraph 0824; 0825
[3] Patent: WO2017/93718, 2017, A1. Location in patent: Page/Page column 80

2-Chloro-3-nitro-4-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-3-nitro-4-pyridinecarboxylic acid Spectrum

2-Chloro-3-nitro-4-pyridinecarboxylic acid 2-Chloro-3-nitropyridine-4-carboxylic acid 353281-15-9
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