2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- N-Pyrazinylcarbonyl-L-phenylalanine Methyl Ester (IS,2S,3R,5S)-Pinanediol-L-phenylalanine-L-leucine boronate, HCl salt Bortezomib Impurity 68 Bortezomib Impurity 32

Bortezomib Impurity 6 (S)-(+)-PINANEDIOL (DICHLORMETHYL)BORONATE Methanone, 1H-imidazol-1-yl-2-pyrazinyl- 4,6-Methano-1,3,2-benzodioxaborole-2-MethanaMine,hexahydro-3a,5,5-triMethyl-a-(2-Methylpropyl)-N,N-bis(triMethylsilyl)-,(aR,3aS,4S,6S,7aR)- Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-

Bortezomib Impurity 60 4,6-Methano-1,3,2-benzodioxaborole-2-methanamine Isovaleraldehyde Bortezomib Impurity 8 4,6-Methano-1,3,2-benzodioxaborole,2-[(1S)-1-chloro-3-Methylbutyl]hexahydro-3a,5,5-triMethyl-,(3aS,4S,6S,7aR)-

BortezoMib IMpurity N Desisobutyl-n-butyl BortezoMib Bortezomib Impurity 9