2,4-dibromo-5-methoxyaniline
- CAS No.
- 35736-52-8
- Chemical Name:
- 2,4-dibromo-5-methoxyaniline
- Synonyms
- 2,4-dibromo-5-methoxyaniline;Benzenamine, 2,4-dibromo-5-methoxy-
- CBNumber:
- CB32741492
- Molecular Formula:
- C7H7Br2NO
- Molecular Weight:
- 280.94
- MDL Number:
- MOL File:
- 35736-52-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,4-Dibromo-5-methoxyaniline | KBA73652 | 5g | $295 |
| 2,4-Dibromo-5-methoxyaniline 95% | AS49480 | 1g | $47 |
| 2,4-Dibromo-5-methoxyaniline 95% | AS49480 | 5g | $104 |
| 2,4-Dibromo-5-methoxyaniline 95% | AS49480 | 25g | $323 |
| 2,4-Dibromo-5-methoxyaniline 95+% | D45868 | 250mg | $44 |
| More product size | |||
2,4-dibromo-5-methoxyaniline price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | KBA73652 | 2,4-Dibromo-5-methoxyaniline | 35736-52-8 | 5g | $295 | 2026-06-04 | Buy |
| Activate Scientific | AS49480 | 2,4-Dibromo-5-methoxyaniline 95% | 35736-52-8 | 1g | $47 | 2026-06-04 | Buy |
| Activate Scientific | AS49480 | 2,4-Dibromo-5-methoxyaniline 95% | 35736-52-8 | 5g | $104 | 2026-06-04 | Buy |
| Activate Scientific | AS49480 | 2,4-Dibromo-5-methoxyaniline 95% | 35736-52-8 | 25g | $323 | 2026-06-04 | Buy |
| Synthonix | D45868 | 2,4-Dibromo-5-methoxyaniline 95+% | 35736-52-8 | 250mg | $44 | 2026-05-06 | Buy |
2,4-dibromo-5-methoxyaniline Chemical Properties,Uses,Production
Synthesis
536-90-3
59557-92-5
19056-40-7
35736-52-8
Using m-aminoanisole (5.00 g, 40.6 mmol) as starting material, it was dissolved in chloroform (40 mL) and the solution was cooled to 5 °C. N-bromosuccinimide (7.23 g, 40.6 mmol) was added to the cooled solution in batches over 1 hour. After addition, the reaction mixture was continued to be stirred in an ice bath at 5-10 °C for 4 hours. Subsequently, the mixture was warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction mixture was washed sequentially with 2M sodium hydroxide solution (50 mL) and water (60 mL) and then dried over anhydrous sodium sulfate. The solvent was removed by evaporation to give a dark brown viscous liquid. The crude product was separated by silica gel column chromatography (eluent: dichloromethane/hexane, 2:1), first eluting a mixture of 2-bromo-5-methoxyaniline and 2,4-dibromo-5-methoxyaniline. Subsequently, 4-bromo-3-methoxyaniline (860 mg, 10% yield) was eluted as peach-colored crystals with a melting point of 97-98 °C (literature value 93-94 °C); 1H NMR (400 MHz, CDCl3) δ 3.70 (broad single peak, 2H, NH2), 3.80 (single peak, 3H, OCH3), 6.16 (double peaks, J=2.5,8.4 Hz , 1H, ArH), 6.23 (double peaks, J=2.5 Hz, 1H, ArH), 7.23 (double peaks, J=8.4 Hz, 1H, ArH), and the data are in agreement with those reported in the literature. The eluate of the first major band was evaporated to dryness and re-separated by silica gel column chromatography (eluent: ethyl acetate/hexane, 1:2) to afford 2-bromo-5-methoxyaniline (830 mg, 10% yield) as an orange liquid; 1H NMR (400 MHz, CDCl3) δ 3.72 (single peak, 3H, OCH3), 4.07 (broad single peak, 2H NH2), 6.21 (double peak, J=2.9,8.8Hz, 1H, ArH), 6.30 (double peak, J=2.9Hz, 1H, ArH), 7.25 (double peak, J=8.8Hz, 1H, ArH), the data were in agreement with the literature reports. Subsequent elution of the second band gave 2,4-dibromo-5-methoxyaniline (2.66 g, 23% yield) as a brown liquid; Rf (80% ethyl acetate/dichloromethane) 0.87; IR (pure) νmax 3420, 3295, 3176, 2965, 2934, 1620, 1582, 1503, 1278, 1207, 1018 , 805 cm-1; 1H NMR (400 MHz, CDCl3) δ 3.80 (single peak, 3H, OCH3), 4.10 (broad single peak, 2H, NH2), 6.31 (single peak, 1H, ArH), 7.49 (single peak, 1H, ArH); 13C NMR (100 MHz, CDCl3) δ 56.1, 99.3, 99.3 , 99.7, 135.1, 144.3, 155.8; Elemental analysis calculated values (C7H7Br2NO): C 29.93, H 2.51, N 4.99; Measured values: C 30.29, H 2.24, N 4.95%.
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2870 - 2873
[2] Tetrahedron, 2011, vol. 67, # 32, p. 5798 - 5805
2,4-dibromo-5-methoxyaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Changzhou Helios Biomedical Science and Technology Co.,LTD. | +8618961213068 | gaoxue@czhelios.com | China | 512 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 17714375163 | cfzhang@aikonchem.com | China | 19906 | 55 |
| Xinyanhe Pharmatech Co.,Ltd | 0519-85252752 15366845260 | taihuaren@vip.163.com | China | 1049 | 58 |
| Grice Rand (Tianjin) Pharmaceutical Co., Ltd. | 022-83705301 13752403750 | 2966024760@qq.com | China | 775 | 55 |
View Lastest Price from 2,4-dibromo-5-methoxyaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-01-15 | 2,4-dibromo-5-methoxyaniline
35736-52-8
|
1KG | 98.3% | 100 tons | Honest Joy Holdings Limited
|
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- 2,4-dibromo-5-methoxyaniline
35736-52-8
- $0.00
- 98.3%
- Honest Joy Holdings Limited
