1,2,3-1H-Triazole
- CAS No.
- 288-36-8
- Chemical Name:
- 1,2,3-1H-Triazole
- Synonyms
- 1H-1,2,3-TRIAZOLE;1,2,3-TRIAZOLE;2H-1,2,3-Triazole;1h-1,2,3-Trizole;Osotriazole;2H-Triazole;Triazacyclopentadiene;3-Triazole;V-triazole;vic-triazole
- CBNumber:
- CB3290804
- Molecular Formula:
- C2H3N3
- Molecular Weight:
- 69.07
- MDL Number:
- MFCD00014490
- MOL File:
- 288-36-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1H-1,2,3-Triazole 97% | 333662 | 1g | $60.1 |
| 1H-1,2,3-Triazole 97% | 333662 | 5g | $164 |
| 1H-1,2,3-Triazole >98.0%(T) | T1880 | 5g | $115 |
| 1H-1,2,3-Triazole >98.0%(T) | T1880 | 25g | $403 |
| 1H-1,2,3-Triazole Asreported | 289639 | 50g | $433 |
| More product size | |||
| Melting point | 23-25 °C(lit.) |
|---|---|
| Boiling point | 203 °C752 mm Hg(lit.) |
| Density | 1.192 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 225 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetone, Chloroform, Methanol (Slightly) |
| form | Liquid |
| pka | 1.17(at 20℃) |
| color | Clear colorless to yellow |
| Specific Gravity | 1.192 |
| Water Solubility | soluble |
| FreezingPoint | 21.0 to 24.0 ℃ |
| BRN | 104766 |
| InChI | 1S/C2H3N3/c1-2-4-5-3-1/h1-2H,(H,3,4,5) |
| InChIKey | QWENRTYMTSOGBR-UHFFFAOYSA-N |
| SMILES | c1c[nH]nn1 |
| CAS DataBase Reference | 288-36-8(CAS DataBase Reference) |
| FDA UNII | EM7554254W |
| NIST Chemistry Reference | 1H-1,2,3-Triazole(288-36-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-63-36-22 | |||||||||
| Safety Statements | 37/39-26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1,2,3-1H-Triazole price More Price(95)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 333662 | 1H-1,2,3-Triazole 97% | 288-36-8 | 1g | $60.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 333662 | 1H-1,2,3-Triazole 97% | 288-36-8 | 5g | $164 | 2026-04-30 | Buy |
| TCI Chemical | T1880 | 1H-1,2,3-Triazole >98.0%(T) | 288-36-8 | 5g | $115 | 2026-04-30 | Buy |
| TCI Chemical | T1880 | 1H-1,2,3-Triazole >98.0%(T) | 288-36-8 | 25g | $403 | 2026-04-30 | Buy |
| Usbiological | 289639 | 1H-1,2,3-Triazole Asreported | 288-36-8 | 50g | $433 | 2026-06-03 | Buy |
1,2,3-1H-Triazole Chemical Properties,Uses,Production
Description
1,2,3-1H-Triazole is a kind of azole compound. It can effectively promote the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. It is also a useful triazole for proteomics research1. It also find use in research as a bioisostere in medicinal chemistry as well as an building block for more complex chemical compounds, including pharmaceutical drugs such as mubritinib and tazobactam2. It is a main class of hetero-cycles because of its extensive range of biological properties such as antimicrobial, anticancer, anti-tubercular, anti-HIV, antimalarial, antibacterial, antifungal, antiviral and anti-diabetic property3.
Chemical Properties
clear colorless liquid
Uses
It effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. A useful triazole for proteomics research
Uses
A basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifunga l, antibacterial and antiviral activities in bioactive triazoles.
Definition
ChEBI: 1H-1,2,3-triazole is a 1,2,3-triazole. It is a tautomer of a 2H-1,2,3-triazole and a 4H-1,2,3-triazole.
Synthesis Reference(s)
The Journal of Organic Chemistry, 62, p. 9177, 1997 DOI: 10.1021/jo971313o
General Description
2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.
Synthesis
4546-95-6
288-36-8
General procedure for the synthesis of 1,2,3-triazole from 1H-1,2,3-triazole-4,5-dicarboxylic acid: to a 2000 mL four-neck flask was added 1250 mL of pure water and 157.08 g (1.0 mol) of 1H-1,2,3-triazole-4,5-dicarboxylic acid, followed by the addition of 4.71 g (equivalent to 1H-1,2,3-triazole-4,5-dicarboxylic acid 3% by mass) of N,N-diisopropylethylamine. The reaction mixture was heated to 100~110°C under atmospheric pressure and refluxed until the reaction solution was clarified. Refluxing was continued for 1 h. The reaction was monitored by HPLC and terminated when the residue of 1H-1,2,3-triazole-4,5-dicarboxylic acid was less than 1%. After completion of the reaction, filtration was performed. A vacuum pump was used to remove most of the water from the filtrate, which was then replaced with a mechanical pump for high vacuum dehydration. The four-necked flask was mounted on a distillation apparatus and vacuum distillation was carried out, resulting in 66.48 g of 1H-1,2,3-triazole with a molar yield of 96.25% and a GC purity of 99.56%.
References
[1] Patent: CN106946803, 2017, A. Location in patent: Paragraph 0035; 0040; 0041; 0045; 0046; 0050; 0051
[2] Patent: CN105330607, 2016, A. Location in patent: Paragraph 0033; 0034
[3] Chemische Berichte, 1893, vol. 26, p. 2737
1,2,3-1H-Triazole Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanxi Xintianyuan Pharmaceutical Co.Ltd | 15935812338 | Xty001@tychemical.com | China | 3 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
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View Lastest Price from 1,2,3-1H-Triazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-09 | 1,2,3-1H-Triazole
288-36-8
|
$1.00-50.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 1,2,3-1H-Triazole
288-36-8
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 1,2,3-1H-Triazole
288-36-8
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 1,2,3-1H-Triazole
288-36-8
- $1.00-50.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1,2,3-1H-Triazole
288-36-8
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 1,2,3-1H-Triazole
288-36-8
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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