4-Bromo-1-indanone
- CAS No.
- 15115-60-3
- Chemical Name:
- 4-Bromo-1-indanone
- Synonyms
- 4-BROMO-2,3-DIHYDRO-1H-INDEN-1-ONE;SKL642;OZAN-001;4-bromoindanone;4-bromo-1-indanon;4-BROMO-1-INDANONE;4-Bromo-1-Indenone;4-BROMO-INDAN-1-ONE;1-Indanone, 4-bromo-;4-Bromo-1-indanone,97%
- CBNumber:
- CB3310546
- Molecular Formula:
- C9H7BrO
- Molecular Weight:
- 211.06
- MDL Number:
- MFCD01719772
- MOL File:
- 15115-60-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-1-indanone 97% | 644366 | 5g | $353 |
| 4-Bromo-1-indanone 97% | 644366 | 1g | $83.5 |
| 4-Bromo-1-indanone >97.0%(GC) | B3801 | 1g | $23 |
| 4-Bromo-1-indanone >97.0%(GC) | B3801 | 5g | $43 |
| 4-Bromo-1-indanone | 430578 | 1g | $326 |
| More product size | |||
| Melting point | 95-99 °C(lit.) |
|---|---|
| Boiling point | 125°C/1.5mmHg(lit.) |
| Density | 1.608±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| color | Orange-brown |
| InChI | InChI=1S/C9H7BrO/c10-8-3-1-2-7-6(8)4-5-9(7)11/h1-3H,4-5H2 |
| InChIKey | UVVYFYLSZIMKMC-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C(Br)=CC=C2)CC1 |
| CAS DataBase Reference | 15115-60-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | F68K258XWL |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280i-P301+P312a-P337+P313-P501a-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-60-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | NK7536100 | |||||||||
| HS Code | 29147000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-Bromo-1-indanone price More Price(90)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 644366 | 4-Bromo-1-indanone 97% | 15115-60-3 | 5g | $353 | 2023-06-20 | Buy |
| Sigma-Aldrich | 644366 | 4-Bromo-1-indanone 97% | 15115-60-3 | 1g | $83.5 | 2022-05-15 | Buy |
| TCI Chemical | B3801 | 4-Bromo-1-indanone >97.0%(GC) | 15115-60-3 | 1g | $23 | 2026-04-30 | Buy |
| TCI Chemical | B3801 | 4-Bromo-1-indanone >97.0%(GC) | 15115-60-3 | 5g | $43 | 2026-04-30 | Buy |
| Usbiological | 430578 | 4-Bromo-1-indanone | 15115-60-3 | 1g | $326 | 2026-06-03 | Buy |
4-Bromo-1-indanone Chemical Properties,Uses,Production
Chemical Properties
Orange-brown crystalline powder
Uses
4-Bromo-1-indanone is used to prepare N''-indanyl-N-benzopyrazolyl ureas as TRPV1 antagonists for use as analgesics. It is also used to synthesize 1,4-dihydroindeno[1,2-c]pyrazoles as KDR kinase inhibitors.
General Description
4-Bromo-1-indanone is an organic synthetic or pharmaceutical intermediate compound that can be used to prepare the prescription drug Ozanimod. Ozanimod can be used to treat relapsing multiple sclerosis (MS), including clinical solitary syndrome, relapsing-remitting disease and active secondary progressive disease. This drug cannot cure multiple sclerosis, but it can slow down some disabling effects and reduce the frequency of disease recurrence. It can also be used to treat moderate to severe ulcerative colitis.
Hazard
4-Bromo-1-indanone is a compound that is irritating to humans. Contact causes skin irritation and severe eye irritation. Harmful if swallowed.
Toxicology
Mouse of LD50 (intravenous):75 mg/kg
Synthesis
15115-58-9
15115-60-3
General procedure for the synthesis of 4-bromoinden-1-one from 3-(2-bromophenyl)propionic acid: trifluoromethanesulfonic acid (3 equiv.) was slowly added dropwise at 0 °C to an anhydrous dichloromethane (1.0 mL) solution of 3-(2-bromophenyl)propionic acid (0.5 mmol) which was placed in a 12 mL Q-tubepressure tube (provided by QLabtech). Subsequently, the reaction mixture was warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed using the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the reactants completely disappeared. After completion of the reaction, the mixture was poured into ice water and extracted three times with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the target compound 4-bromoinden-1-one was isolated and purified from the crude product by fast column chromatography.
References
[1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 100231
[3] Patent: US2015/25205, 2015, A1. Location in patent: Page/Page column
[4] Patent: WO2015/95188, 2015, A1. Location in patent: Paragraph 00161
[5] Patent: WO2003/99795, 2003, A1. Location in patent: Page 111
4-Bromo-1-indanone Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GuiZhou DoSincerely biological technology Co.,Ltd. | +8613511983931 | 271622643@qq.com | China | 9 | 58 |
| PharmOrgSyn Laboratories Co., Ltd. | +86-021-38228826 +86-13916602830 | sales@pharmorgsyn.cn | China | 139 | 58 |
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1008 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Hangzhou IKSChem Technology Co., Limited | +8613625816949 | zheng@ikschem.com | China | 979 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 670 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
Related Qustion
Ask a questionView Lastest Price from 4-Bromo-1-indanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-09 | 4-Bromo-1-indanone
15115-60-3
|
$1.50-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-18 | 4-Bromo-1-indanone
15115-60-3
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-03-20 | 4-Bromo-1-indanone
15115-60-3
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Bromo-1-indanone
15115-60-3
- $1.50-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Bromo-1-indanone
15115-60-3
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 4-Bromo-1-indanone
15115-60-3
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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