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4'-CHLOROACETANILIDE

4'-CHLOROACETANILIDE structure

CAS No.: 539-03-7

Chemical Name:: 4'-CHLOROACETANILIDE

Synonyms: 4-CHLOROACETANILIDE;paracetamol impurity J;ACETAMINOPHEN IMPURITY J;NSC 444;NSC 40563;4-Chloroacetan;PARACETAMOL RC J;4-CHLORACETANILIDE;p-Chloroacetanilid;P-CHLOROACETANILIDE

CBNumber:: CB3377826

Molecular Formula:: C8H8ClNO

Molecular Weight:: 169.61

MDL Number:: MFCD00000612

MOL File:: 539-03-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:45:43

Product description	Number	Pack Size	Price
Paracetamol impurity J European Pharmacopoeia (EP) Reference Standard	Y0001945	15 mg	$172
4-Chloroacetanilide for synthesis	8.41480	50g	$71.5
4-Chloroacetanilide for synthesis	8.41480	250g	$327
4′-Chloroacetanilide 97%	158631	5g	$47.7
Acetaminophen Related Compound J United States Pharmacopeia (USP) Reference Standard	1003100	50mg	$1340
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4'-CHLOROACETANILIDE Properties

Melting point	176-178 °C(lit.)
Boiling point	333 °C
Density	1,385 g/cm³
refractive index	1.5670 (estimate)
Flash point	333°C
storage temp.	2-8°C
solubility	dioxane: 50 mg/mL hot, clear
pka	14.25±0.70(Predicted)
form	Crystalline Powder
color	White or grayish-beige
Water Solubility	Insoluble in water.
Merck	14,2111
BRN	509638
Henry's Law Constant	2.1×10⁰ mol/(m³Pa) at 25℃, HSDB (2015)
InChI	1S/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)
InChIKey	GGUOCFNAWIODMF-UHFFFAOYSA-N
SMILES	CC(=O)Nc1ccc(Cl)cc1
CAS DataBase Reference	539-03-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	6I0LI34G5J
EPA Substance Registry System	4-Chloroacetanilide (539-03-7)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

AE1001000

TSCA

TSCA listed

HS Code

29242990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Hazardous Substances Data

539-03-7(Hazardous Substances Data)

NFPA 704

	0
1		0

4'-CHLOROACETANILIDE price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001945	Paracetamol impurity J European Pharmacopoeia (EP) Reference Standard	539-03-7	15 mg	$172	2026-04-30	Buy
Sigma-Aldrich	8.41480	4-Chloroacetanilide for synthesis	539-03-7	50g	$71.5	2026-04-30	Buy
Sigma-Aldrich	8.41480	4-Chloroacetanilide for synthesis	539-03-7	250g	$327	2026-04-30	Buy
Sigma-Aldrich	158631	4′-Chloroacetanilide 97%	539-03-7	5g	$47.7	2026-04-30	Buy
Sigma-Aldrich	1003100	Acetaminophen Related Compound J United States Pharmacopeia (USP) Reference Standard	539-03-7	50mg	$1340	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0001945	15 mg	$172	Buy
8.41480	50g	$71.5	Buy
8.41480	250g	$327	Buy
158631	5g	$47.7	Buy
1003100	50mg	$1340	Buy

4'-CHLOROACETANILIDE Chemical Properties,Uses,Production

Chemical Properties

white or greyish-beige crystalline powder

Uses

4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.

Definition

ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.

Synthesis Reference(s)

Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4

General Description

4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.

Synthesis

Preparation of p-chloroacetanilide: 113.5 mg (0.5 mmol) of 4-chlorophenyl diazonium tetrafluoroborate, 0.1 mmol of cuprous iodide, 0.5 mmol of potassium phosphate with 1.0 mmol of water were added to a Schlenk tube under nitrogen and 1 mL of acetonitrile was added under air and the reaction was stirred for 12 hr at 80oC, the yield of the reaction was 68%.

Purification Methods

Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]

4'-CHLOROACETANILIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID Ethanone,1-(2-amino-5-chlorophenyl)- 2,6-DICHLORO-1,4-BENZOQUINONE 2'-Chloroacetanilide 5-Chloroorthanilic acid

N-(4-CHLOROPHENYL)-N-ETHYLFORMAMIDE

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4'-CHLOROACETANILIDE Suppliers

Global( 378)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3861	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from 4'-CHLOROACETANILIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4'-CHLOROACETANILIDE 539-03-7	$1.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	4'-CHLOROACETANILIDE 539-03-7		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2024-04-25	4'-CHLOROACETANILIDE 539-03-7	$10.00	1kg	99.8%	10000ton	Ouhuang Engineering Materials (Hubei) Co., Ltd

4'-CHLOROACETANILIDE
539-03-7
$1.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4'-CHLOROACETANILIDE
539-03-7
98%
Henan Aochuang Chemical Co.,Ltd.

4'-CHLOROACETANILIDE
539-03-7
$10.00
99.8%
Ouhuang Engineering Materials (Hubei) Co., Ltd

4'-CHLOROACETANILIDE Spectrum

4'-CHLOROACETANILIDE(539-03-7)MS 4'-CHLOROACETANILIDE(539-03-7)¹HNMR 4'-CHLOROACETANILIDE(539-03-7)IR1 4'-CHLOROACETANILIDE(539-03-7)IR2 4'-CHLOROACETANILIDE(539-03-7)Raman

539-03-7(4'-CHLOROACETANILIDE)Related Search:

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ACETIC ACID 4-CHLOROANILIDE ACETAMINOPHENE IMP J 4'-CHLOROACETANILIDE 4-CHLORACETANILIDE LABOTEST-BB LT00792311 P-CHLOROACETANILIDE N-(4-CHLORO-PHENYL)-ACETAMIDE P-ChloroAcetanilide-(AceticAcid-4-Chloroanilide,4-ChloroAcetanilide) P-ChloroAcetanilideGr-(AceticAcid-4-Chloroanilide,4-ChloroAcetanilide) P-ChloroAcetanilideGr 4''-CHLOROACETANILIDE, 98+% p-CHLOROACETANILIDE extrapure AR 4'-Chloroacetanilide,97% 4′-Chloroacetanilide,Acetic acid 4-chloroanilide NSC 40563 NSC 444 p-Chloroacetanilid AcetaMinophen IMpurity J (ParacetaMol IMpurity J) AcetaMinophen Related CoMpound J 4-Chloroacetan Acetaminophen Related Compound J (50 mg) (N-(4-chlorophenyl)acetamide) Paracetamol Impurity-J(EP/BP) 4’-chloro-acetanilid 4-chlorophenylethanamide Acetamide,N-(4-chlorophenyl)- Acetanilide, 4'-chloro- Acetic-4-chloroanilide Acet-p-chloroanilide amide,n(4-chlorophenyl)-aceticaci ethanamide,4-chlorophenyl- n-(4-chlorophenyl)-acetamid N-(p-Chlorophenyl)acetamide N-Acetyl-4-chloroaniline N-Acetyl-p-chloroaniline p-Chloroacetoanilide 4-Chloroacetanilide (Acetaminophen RCJ) Acetaminophen impurity 10 Paracetamol EP Impurity J Paracetamol Impurity 10(Paracetamol EP Impurity J) 4’-CHLOROACETANILIDE(Acetaminophen Related Compound J) 4'-Chloroacetanilide > N-(4-Chlorophenyl)acetamide (4-Chlo 4-CHLOROACETANILIDE FOR SYNTHESIS Paracetamol(Acetaminophen) EP Impurity J Parachloroacetanilide 4-Chloroacetanilide/ Paracetamol Impurity-J Paracetamol Impurity-J/4-Chloroacetanilide Acetaminophen impurities1464 Acetaminophen EP Impurity J Acetaminophen Related Compound J (R00310) p-Chloroacetanilide, GR 99%+ p-Chloroacetanilide extrapure AR, ExiPlus, Multi-Compendial, 99% Paracetamol EP Impurity JQ: What is Paracetamol EP Impurity J Q: What is the CAS Number of Paracetamol EP Impurity J Q: What is the storage condition of Paracetamol EP Impurity J Q: What are the applications of Paracetamol EP Impurity J Acetaminophen Related Compound J (N-(4-chlorophenyl)acetamide) (1003100) Acetaminophen USP Related Compound J N-(4-chlorophenyl)acetamide(chloroacetanilide) 4-ChloroacetaNAide, 97% Acetaminophene Related Compound J

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