4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
- CAS No.
- 304897-49-2
- Chemical Name:
- 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
- Synonyms
- 4-(4-Boc-piperazin-1-yl-methyl)aniline;4-[(4-Boc-1-piperazinyl)methyl]aniline;4-(1-BOC-PIPERAZIN-4-YL-METHYL)-ANILINE;4-(4-Aminobenzyl)piperazine, N1-BOC protected;4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline;tert-butyl 4-(4-aMinobenzyl)piperazine-1-carboxylate;4-(4-aminobenzyl)piperazine-1-carboxylic acid tertbut;ert-butyl4-[(4-aminophenyl)methyl]piperazine-1-carboxylate;tert-butyl 4-[(4-aMinophenyl)Methyl]piperazine-1-carboxylate;4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber:
- CB3386716
- Molecular Formula:
- C16H25N3O2
- Molecular Weight:
- 291.39
- MDL Number:
- MFCD06797795
- MOL File:
- 304897-49-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 265878 | 250mg | $347 |
| 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 265878 | 500mg | $475 |
| 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 265878 | 1g | $751 |
| 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 265878 | 2g | $1040 |
| 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 265878 | 5g | $1457 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265878 | 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 304897-49-2 | 250mg | $347 | 2026-06-03 | Buy |
| Usbiological | 265878 | 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 304897-49-2 | 500mg | $475 | 2026-06-03 | Buy |
| Usbiological | 265878 | 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 304897-49-2 | 1g | $751 | 2026-06-03 | Buy |
| Usbiological | 265878 | 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 304897-49-2 | 2g | $1040 | 2026-06-03 | Buy |
| Usbiological | 265878 | 4-(1-Boc-piperazin-4-yl-methyl)aniline Asreported | 304897-49-2 | 5g | $1457 | 2026-06-03 | Buy |
4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Uses
4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester is a carboxylic acid ester derivative and can be used as a pharmaceutical intermediate.
Synthesis
130636-61-2
304897-49-2
Tert-butyl 4-(4-nitrobenzyl)piperazine-1-carboxylate (1.100 g, 3.423 mmol) was added to a solvent mixture of tetrahydrofuran solution (20 mL) of ammonium chloride (0.915 g, 17.114 mmol) and zinc powder (1.119 g, 17.114 mmol) with water (20 mL) as starting material, and the reaction was stirred for 12 h at room temperature. . Upon completion of the reaction, the reaction mixture was filtered to remove solid impurities. Water was added to the filtrate and subsequently extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting product, tert-butyl 4-(4-aminobenzyl)piperazine-1-carboxylate (0.900 g, 90.2% yield), was a yellow solid and could be used in subsequent reactions without further purification.
References
[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 1492; 1493; 1494
[4] Patent: WO2016/146220, 2016, A1. Location in patent: Page/Page column 26; 27
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518
4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 | 1097@dideu.com | China | 3992 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8886 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10457 | 58 |
View Lastest Price from 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-11-18 | 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-20 | 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
- $1.00
- 99%
- Career Henan Chemical Co
