2-Chloro-6-cyanopyridine
- CAS No.
- 33252-29-8
- Chemical Name:
- 2-Chloro-6-cyanopyridine
- Synonyms
- 6-CHLOROPICOLINONITRILE;2-Cyano-6-chloropyridine;oro-6-Cyanopyridine;2-Cyno-6-chloropyridine;6-CHLORO-2-CYANOPYRIDINE;2-CHLORO-6-CYANOPYRIDINE;2-Chloro-6-pyridinenitrile;P-1002-Chloro-6-Cyanopyridine;6-Chloropyridin-2-carbonitrile;6-CHLOROPYRIDINE-2-CARBONITRILE
- CBNumber:
- CB3423721
- Molecular Formula:
- C6H3ClN2
- Molecular Weight:
- 138.55
- MDL Number:
- MFCD00274527
- MOL File:
- 33252-29-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Chloropyridine-2-carbonitrile 96% | 665967 | 1g | $121 |
| 6-Chloropyridine-2-carbonitrile 96% | 665967 | 5g | $396 |
| 6-Chloro-2-cyanopyridine 96% | AS7206 | 1g | $23 |
| 6-Chloro-2-cyanopyridine 96% | AS7206 | 5g | $39 |
| 6-Chloropyridine-2-carbonitrile 96% | OR4835 | 1g | $21 |
| More product size | |||
| Melting point | 85-89 °C |
|---|---|
| Boiling point | 245.3±20.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -5.77±0.10(Predicted) |
| form | powder |
| color | White |
| InChI | InChI=1S/C6H3ClN2/c7-6-3-1-2-5(4-8)9-6/h1-3H |
| InChIKey | PGZHSVWXFKKCNR-UHFFFAOYSA-N |
| SMILES | C1(C#N)=NC(Cl)=CC=C1 |
| CAS DataBase Reference | 33252-29-8(CAS DataBase Reference) |
| FDA UNII | ZS4YVY14OF |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H319-H332-H301-H315-H318-H335 | |||||||||
| Precautionary statements | P280h-P309-P310-P261-P280-P301+P310-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 22-37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-37 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloro-6-cyanopyridine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 665967 | 6-Chloropyridine-2-carbonitrile 96% | 33252-29-8 | 1g | $121 | 2023-06-20 | Buy |
| Sigma-Aldrich | 665967 | 6-Chloropyridine-2-carbonitrile 96% | 33252-29-8 | 5g | $396 | 2023-06-20 | Buy |
| Activate Scientific | AS7206 | 6-Chloro-2-cyanopyridine 96% | 33252-29-8 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS7206 | 6-Chloro-2-cyanopyridine 96% | 33252-29-8 | 5g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR4835 | 6-Chloropyridine-2-carbonitrile 96% | 33252-29-8 | 1g | $21 | 2026-06-04 | Buy |
2-Chloro-6-cyanopyridine Chemical Properties,Uses,Production
Chemical Properties
Off-white Cryst
Uses
Substrate used in a Negishi coupling reaction with an arylzinc halide catalyzed by Pd-NHC (PEPPSI-Ipr, Catalog No. 668032).
Synthesis
773837-37-9
87512-29-6
33252-29-8
The reaction was carried out with 2-chloro-6-(methylsulfonyl)pyridine (13.0 g, 67.8 mmol) and sodium cyanide (6.69 g, 136 mmol) in DMF (150 ml) with stirring at 170°C for 18 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into water and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent petroleum ether-ethyl acetate (2:1, v/v) to afford 2-chloro-6-cyanopyridine (6.67 g, 71% yield) as white crystals with a melting point of 82.9-83.1 °C. IR (KBr, cm-1): 2253 (CN), 1572, 1431, 1161. 1143, 912, 854, 744. 1H-NMR (CDCl3, δ): 7.57 (1H, d, J = 8.0 Hz), 7.65 (1H, d, J = 8.1 Hz), 7.82 (1H, t, J = 7.8 Hz).
References
[1] Patent: EP1424336, 2004, A1. Location in patent: Page 41
2-Chloro-6-cyanopyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9631 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
View Lastest Price from 2-Chloro-6-cyanopyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Chloro-6-cyanopyridine
33252-29-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | 2-Chloro-6-cyanopyridine
33252-29-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-13 | 2-Chloro-6-cyanopyridine
33252-29-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Chloro-6-cyanopyridine
33252-29-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloro-6-cyanopyridine
33252-29-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Chloro-6-cyanopyridine
33252-29-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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