Description
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 (±)11(12)-DiHET relaxes U-46619 (Item No. 16450)-contracted artery rings with approximately 70% of the magnitude of (±)11(12)-EET (Item No. 50511).2WARNING This product is not for human or veterinary use.
References
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[3] YILIN PANG . LC?MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI: 10.1016/j.freeradbiomed.2022.10.303
[4] CARLOS ARTéRIO SORGI. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays[J]. Scientific Data, 2018, 5 1: 1-12. DOI: 10.1038/sdata.2018.167
[5] JAMIE L LAHVIC. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 37: 9252-9257. DOI: 10.1073/pnas.1806077115
[6] YINDI DING. The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.[J]. Journal of Pharmacology and Experimental Therapeutics, 2014, 350 1: 14-21. DOI: 10.1124/jpet.114.214254
