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ChemicalBook >> CAS DataBase List >>Emodin-3-methyl ether

Emodin-3-methyl ether

CAS No.
521-61-9
Chemical Name:
Emodin-3-methyl ether
Synonyms
PHYSCION;PHYSCIONE;RHEOCHRYSIDIN;parietin;MethyleModin;Rheochrysidin (Physcion);Emodin-3-methyl ether 521-61-9;1,8-dihydroxy-3-Methoxy-6-Methylanthracene-9,10-dione;Physcion-RM;Physcic acid
CBNumber:
CB3487525
Molecular Formula:
C16H12O5
Molecular Weight:
284.26
MDL Number:
MFCD00017374
MOL File:
521-61-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-02 09:21:32
Product description Number Pack Size Price
Physcion analytical standard 93893 10mg $334
Physcion ≥98.0% (TLC) 17797 100mg $730
Physcion P2931 100MG $189
Physcion ≥98% 19863 5mg $36
Physcion ≥98% 19863 10mg $63
More product size

Emodin-3-methyl ether Properties

Melting point 196-206°C
Boiling point 560.5±50.0 °C(Predicted)
Density 1.448±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form Solid
pka 6.23±0.20(Predicted)
color Yellow to Dark Yellow to Dark Orange
BRN 6770499
Stability Hygroscopic
Major Application food and beverages
InChI InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
InChIKey FFWOKTFYGVYKIR-UHFFFAOYSA-N
SMILES C1(O)=C2C(C(=O)C3=C(C2=O)C(O)=CC(C)=C3)=CC(OC)=C1
LogP 5.078 (est)
CAS DataBase Reference 521-61-9(CAS DataBase Reference)
FDA UNII H6PT94IV61
UNSPSC Code 85151701
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
RTECS  CB6720000
F  10
HS Code  29146990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
0
2 0

Emodin-3-methyl ether price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 93893 Physcion analytical standard 521-61-9 10mg $334 2026-04-30 Buy
Sigma-Aldrich 17797 Physcion ≥98.0% (TLC) 521-61-9 100mg $730 2026-04-30 Buy
TCI Chemical P2931 Physcion 521-61-9 100MG $189 2026-04-30 Buy
Cayman Chemical 19863 Physcion ≥98% 521-61-9 5mg $36 2026-04-30 Buy
Cayman Chemical 19863 Physcion ≥98% 521-61-9 10mg $63 2026-04-30 Buy
Product number Packaging Price Buy
93893 10mg $334 Buy
17797 100mg $730 Buy
P2931 100MG $189 Buy
19863 5mg $36 Buy
19863 10mg $63 Buy

Emodin-3-methyl ether Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.

Uses

antibacterial, cathartic

Definition

ChEBI: A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6.

Biological Activity

Anthraquinone-derivative found in medicinal herbs.

in vivo

Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model[3]. Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens[4].

Animal Model:Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats[3]
Dosage:20 or 40 mg/kg
Administration:Oral gavage (p.o.), once daily for 7 days
Result:Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group. Obviously decreased areas of infarction compared to I/R group.
Animal Model:SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE[4]
Dosage:4 or 9 mg/kg
Administration:Oral gavage (p.o.), once daily for 6 days
Result:Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.

IC 50

TLR4

518-82-1
77-78-1
521-61-9
Synthesis of Emodin-3-methyl ether from Emodin and Dimethyl sulfate
Global( 418)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Xianhe Biotech Co., Ltd 		+86-17709210191; +8617709210191 Jerry@xhobio.com China 906 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu Greenpure Biopharma CO.,Ltd 		18283602253; +8618283602253 jancyzheng@gcgreenpure.com China 954 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691 yklbiotech@163.com CHINA 296 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 4616 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Xi'an Kono chem co., Ltd., 		029-86107037 13289246953 info@konochemical.com China 1169 58
Shaanxi Pioneer Biotech Co., Ltd . 		+8613259417953 sales@pioneerbiotech.com China 1287 58

View Lastest Price from Emodin-3-methyl ether manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Emodin-3-methyl ether pictures 2026-06-06 Emodin-3-methyl ether
521-61-9
 20MG ≥98% HPLC 100kg Changsha Staherb Natural Ingredients Co., Ltd.
Physcion pictures 2026-06-02 Physcion
521-61-9
 1KG 0.99 1000KG Shaanxi Xianhe Biotech Co., Ltd
Physcion pictures 2026-06-01 Physcion
521-61-9
 $43.00-129.00 97.35% 10g TargetMol Chemicals Inc.
  • Physcion pictures
  • Physcion
    521-61-9
  • $0.00
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd
  • Physcion pictures
  • Physcion
    521-61-9
  • $43.00-129.00
  • 97.35%
  • TargetMol Chemicals Inc.

Emodin-3-methyl ether Spectrum

3-methoxy-6-methyl- 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone EMODIN-3-METHYLETHER(RG)(CALL) 1,8-Dihydroxy-3-Methoxy-6-Methyl- Rheochrysidin (Physcione) Physcic acid Przewalskinone B Physcion, froM RheuM palMatuM Physcion, >=98% Physcion, Emodin-3-methyl ether 1,8-DIHYDROXY-3-METHOXY-6-METHYLANTHRAQUINONE EMODIN 3-METHYL ETHER PHYSCION WITH HPLC 1,8-dihydroxy-3-methoxy-6-methyl-10-anthracenedione 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione 1,8-dihydroxy-3-methoxy-6-methyl-anthraquinon 1,8-dihydroxy-3-methyl-6-methoxy-9,10-anthraquinone 1,8-dihydroxy-3-methoxy-6-methylanthraquinone emodin 3-methyl ether Physcion Physcion PHYSCION(SH) ANTHRAQUINONE,1,8-DIHYDROXY-3-METHOXY-6-METHYL- EMODIN 3-METHYL ETHER hplc Physcion, 98%, from Rheum palmatum 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- Rhubarb extract/Emodin-3-methyl ether Rheochrysidin (Parietin 5'-Tetramethylbenzidine dihydrochloride parietin Emodin-3-methyl ether 521-61-9 Rheochrysidin (Physcion) Emodin methyl ether Physcione|||Parietin|||Rheochrysidin Physcion-RM Emodinum methylicum Physcion (Standard) 1,8-dihydroxy-3-Methoxy-6-Methylanthracene-9,10-dione MethyleModin PHYSCION PHYSCIONE RHEOCHRYSIDIN 521-61-9 521-61-0 Agro-Products Aromatics Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract The group of Polydatin Anthraquinones, Hydroquinones and Quinones
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