ChemicalBook >> CAS DataBase List >>1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one structure

CAS No.: 4746-97-8

Chemical Name:: 1,4-Dioxaspiro[4.5]decan-8-one

Synonyms: 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;cyclohexanedione monoethylene ketal;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;1,4-Cyclohexanedione ethylene ketal;Cyclohexane-1,4-dione monoethylene ketal;1 4-dioxiro[4.5]decan-8-one pharmaceutical intermediate;KEHK;4-Cyclohexanedione Mo;cyclohexanedione monoacetal;4-Dioxaspiro[4.5]decan-8-one

CBNumber:: CB3496677

Molecular Formula:: C8H12O3

Molecular Weight:: 156.18

MDL Number:: MFCD00010214

MOL File:: 4746-97-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:26:21

Product description	Number	Pack Size	Price
1,4-Cyclohexanedione monoethylene acetal 97%	274879	5g	$46.1
1,4-Cyclohexanedione monoethylene acetal 97%	274879	25g	$85.2
1,4-Cyclohexanedione Monoethyleneketal >98.0%(GC)	C1292	5g	$19
1,4-Cyclohexanedione Monoethyleneketal >98.0%(GC)	C1292	25g	$42
1,4-Cyclohexanedione monoethlylene acetal Asreported	269023	50g	$333
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1,4-Dioxaspiro[4.5]decan-8-one Properties

Melting point	70-73 °C (lit.)
Boiling point	112C
Density	1.0887 (rough estimate)
refractive index	1.4430 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in chloroform & methanol.
form	Crystalline Powder or Crystals
color	White to beige
Sensitive	Moisture Sensitive
BRN	117631
InChI	InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
InChIKey	VKRKCBWIVLSRBJ-UHFFFAOYSA-N
SMILES	O1C2(CCC(=O)CC2)OCC1
CAS DataBase Reference	4746-97-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-36/37/39-26

WGK Germany

8-10-21

Hazard Note

Irritant

HS Code

29110000

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

1,4-Dioxaspiro[4.5]decan-8-one price More Price(123)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	274879	1,4-Cyclohexanedione monoethylene acetal 97%	4746-97-8	5g	$46.1	2026-04-30	Buy
Sigma-Aldrich	274879	1,4-Cyclohexanedione monoethylene acetal 97%	4746-97-8	25g	$85.2	2026-04-30	Buy
TCI Chemical	C1292	1,4-Cyclohexanedione Monoethyleneketal >98.0%(GC)	4746-97-8	5g	$19	2026-04-30	Buy
TCI Chemical	C1292	1,4-Cyclohexanedione Monoethyleneketal >98.0%(GC)	4746-97-8	25g	$42	2026-04-30	Buy
Usbiological	269023	1,4-Cyclohexanedione monoethlylene acetal Asreported	4746-97-8	50g	$333	2026-06-03	Buy

Product number	Packaging	Price	Buy
274879	5g	$46.1	Buy
274879	25g	$85.2	Buy
C1292	5g	$19	Buy
C1292	25g	$42	Buy
269023	50g	$333	Buy

1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Uses,Production

Chemical Properties

1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals

Uses

1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

Intermediates of Liquid Crystals

Uses

1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Application

1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.

Synthesis

In a dry Schlenk tube, [Rh(cod)Cl]2 (9.9 mg, 20.0 mol), (R)-Binap (27.4 mg, 44.0 mol), and Durum (20.0 mg, internal standard) were dissolved in CH2Cl2 (8.0 mL); then, 2 mmol of the substrate was added to the solution at room temperature under nitrogen. After stirring for 1 min, CF3CO2Ag (8.8 mg, 40.0 mol) was added to the mixture. The solution was stirred at 25C under nitrogen and monitored by GC or HPLC to determine the conversion and ee values. After evaporation of the solvent, the residue was purified by chromatography using EtOAc/hexane (20/80) as eluent to give the product 1,4-cyclohexanedione monoethylene glycol ketal.

Purification Methods

Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]

1,4-Dioxaspiro[4.5]decan-8-one synthesis

Synthesis of 1,4-Dioxaspiro[4.5]decan-8-one from 2,5-dioxo-1,4-cyclohexanedicarboxylic acid dimethyl ester and Ethylene glycol

1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

4,4-DIFLUOROCYCLOHEXANONE methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-CYCLOHEXEN-1-YL]-MORPHOLINE Pramipexole impurity 7 4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&

4-Methoxycyclohexanol 4-(Benzyloxy)cyclohexanone 4-Pentylcyclohexanone INCB8761(PF-4136309) 4-Propylcyclohexanone

4-CYANOCYCLOHEXANONE CYCLIC ETHYLENE ACETAL 4-Methoxycyclohexanon

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1,4-Dioxaspiro[4.5]decan-8-one Suppliers

Global( 610)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
Hebei Maison Chemical Co.,Ltd.	+8615511852758	sales@maisonchem.com.cn	China	484	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58

Supplier	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
Hebei Maison Chemical Co.,Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58

Synthesis and Synthetic Applications of 1,4-Dioxaspiro[4.5]decan-8-one
1,4-Dioxaspiro[4.5]decan-8-one has been reported to serve as a basic chemical raw material for the synthesis of natural produc....
Dec 10，2025

View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-24	1,4-Cyclohexanedione monoethyleneacetal 4746-97-8	$20.00	1KG	99%	300 Tons/ year	Speranza Chemical Co., Ltd.
2026-07-24	1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-15	1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8	$289.00	1KG	98%	1-10MT	Baoji Guokang Healthchem Co., Ltd.

1,4-Cyclohexanedione monoethyleneacetal
4746-97-8
$20.00
99%
Speranza Chemical Co., Ltd.

1,4-Dioxaspiro[4.5]decan-8-one
4746-97-8
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1,4-Dioxaspiro[4.5]decan-8-one
4746-97-8
$289.00
98%
Baoji Guokang Healthchem Co., Ltd.

1,4-Dioxaspiro[4.5]decan-8-one Spectrum

1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)MS 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)¹HNMR 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)¹³CNMR 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)IR1 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)IR2 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)Raman

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Substituted 1,2,4,9-tetrahydrospiro[carbazole-3,2'-[1,3]dioxane] 1,4-Cyclohexanedione monoethlylene acetal 1,4-Cyclohexanedione monoethylene ketal for synthesis 4-Dioxaspiro[4.5]decan-8-one 1,4-Cyclohexanedion monoethylene acetal 1,4-Dioxiro[4.5]decan-8-one. 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL (1,4-DIOXASPIRO(4.5)DECAN-8-ONE) 1,4-Dioxaspiro[4.5]decan-8-one, Cyclohexane-1,4-dione monoethylene ketal Cyclohexane-1,4-dione monoethylene acetal KEHK 1,4-Dioxaspiro[4.5]decan-8-one ,99% 1,4-DIOXASPIRO[4.5]DECAN-8-ONE 1,4-DIOXASPIRO[4.5]-8-DECANONE CYCLOHEXANEDIONE(1,4-) MONOETHYLENE 4-Cyclohexanedione Monoethylene acetal 1,4-Dioxaspiro[4.5]decan-8-one 99% Cyclohexane-1,4-dione monoethylene ketal, Cyclohexane-1,4-dione monoethylene acetal 1,4-Cyclohexanedion Monoethyl 1,4-Dioxaspiro[4.5]decan-8-one, 98% 25GR Cyclohexane-1,4-dione monoethylene ketal, 8-Oxo-1,4-dioxaspiro[4.5]decane Ethylene glycolcyclohexanoneketalsingleloop 1,4- 1,4-Cyclohexanedione Monoethylene acetal 97% 1,4-Dioxaspiro[4.5]decan-8-one, 95+% 1,4-Dioxaspiro[4.5]decane-8-one- 4,4-(Ethylenebisoxy)cyclohexan-1-one 7,10-Dioxaspiro[5.4]decane-3-one Spiro[cyclohexane-1,2'-1,3-dioxolane]-4-one 1,4-Cyclohexanedione monoethylene acetal (1,4-Dioxaspiro(4 x 5)d Cyclohexanedione monoethyleneacetal 1,4-Dioxaspiro[4.5]decan-8-one,98% 1, 4 - cyclohexanol diketone glycol ketal 1,4-Dioxaspiro[4,5!decan-8-one, 97+% Cyclohexane-1,4-dione monoethylene acetal 99% 1,4-Dioxaspiro[4.5]decan-8-one/1,4-Cyclohexanedione Monoethylene Ketal 1,4-cyclohexanedione monoacetal Monoethylene glycol 1,4- cyclohexyl diketone 4-Cyclohexanedione Mo 1,4-cyclohexanedione monoethylene ketal 4746-97-8 1,4-Cyclohexanedione Monoethyleneketal > 1,4 cyclohexanedione monoethylene glycol acetophenone 1,4-Cyclohexanedione monoketal 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8) 1,4-Cyclohexanedione ethylene ketal 1,4-Dioxaspiro[4.5]decan-8-one (6CI, 7CI, 8CI, 9CI, ACI) 1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL > 97% puriss for synthesis 1,4-Cyclohexanedione monoethylene cyclohexanedione monoacetal 1.4-Cyclohexanedione monoethylene glycol ketal KCR 1,4-Cyclohexanedioneglycolmonoketal 1,4-Dioxaspiro[4.5]decan-8-one - [D7118] 1,4-Cyclohexanedione Monoethylene Acetal(KCR) 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL 1 4-dioxiro[4.5]decan-8-one pharmaceutical intermediate 1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL Cyclohexane-1,4-dione monoethylene ketal cyclohexanedione monoethylene ketal 4746-97-8 4740-97-8

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1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one Properties

SAFETY

Risk and Safety Statements

1,4-Dioxaspiro[4.5]decan-8-one price More Price(123)

1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Uses

Application

Synthesis

Purification Methods

1,4-Dioxaspiro[4.5]decan-8-one synthesis

1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

1,4-Dioxaspiro[4.5]decan-8-one Suppliers

Related articles

View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers

1,4-Dioxaspiro[4.5]decan-8-one Spectrum

4746-97-8(1,4-Dioxaspiro[4.5]decan-8-one)Related Search: