3-Amino-4-chlorobenzoic acid
- CAS No.
- 2840-28-0
- Chemical Name:
- 3-Amino-4-chlorobenzoic acid
- Synonyms
- 4,3-CABA;3-Amino-4-chL;3-Amino-4-chloro;TIMTEC-BB SBB003842;Intedanib Impurity 4;4-chloro-3-AMino acid;Sunitinib Impurity 68;5-CARBOXY-2-CHLOROANILINE;3-Amino-4-chlorbenzoesure;3-AMINO-4-CHLOROBENZOIC ACID
- CBNumber:
- CB3680342
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00007671
- MOL File:
- 2840-28-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Amino-4-chlorobenzoic acid ≥98.0% (T) | 07370 | 25g | $51.4 |
| 3-Amino-4-chlorobenzoic Acid >98.0%(HPLC)(T) | A0635 | 25g | $24 |
| 3-Amino-4-chlorobenzoic Acid >98.0%(HPLC)(T) | A0635 | 500g | $208 |
| 3-Amino-4-chlorobenzoic Acid | TRC-A617745-5G | 5g | $65 |
| 3-Amino-4-chlorobenzoic Acid | TRC-A617745-50G | 50g | $109 |
| More product size | |||
| Melting point | 214-215 °C (lit.) |
|---|---|
| Boiling point | 250°C (rough estimate) |
| Density | 1.3246 (rough estimate) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.5560 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.13±0.10(Predicted) |
| form | Powder |
| color | Light beige to beige |
| BRN | 2085846 |
| Major Application | peptide synthesis |
| InChI | 1S/C7H6ClNO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,9H2,(H,10,11) |
| InChIKey | DMGFVJVLVZOSOE-UHFFFAOYSA-N |
| SMILES | Nc1cc(ccc1Cl)C(O)=O |
| LogP | 1.6 at 25℃ |
| Dissociation constant | 2.7-2.9 at 25℃ |
| CAS DataBase Reference | 2840-28-0(CAS DataBase Reference) |
| FDA UNII | 3Q8R4430CF |
| NIST Chemistry Reference | 3-Amino-4-chlorobenzoic acid(2840-28-0) |
| EPA Substance Registry System | Benzoic acid, 3-amino-4-chloro- (2840-28-0) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29224995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Amino-4-chlorobenzoic acid price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 07370 | 3-Amino-4-chlorobenzoic acid ≥98.0% (T) | 2840-28-0 | 25g | $51.4 | 2023-06-20 | Buy |
| TCI Chemical | A0635 | 3-Amino-4-chlorobenzoic Acid >98.0%(HPLC)(T) | 2840-28-0 | 25g | $24 | 2026-04-30 | Buy |
| TCI Chemical | A0635 | 3-Amino-4-chlorobenzoic Acid >98.0%(HPLC)(T) | 2840-28-0 | 500g | $208 | 2026-04-30 | Buy |
| TRC | TRC-A617745-5G | 3-Amino-4-chlorobenzoic Acid | 2840-28-0 | 5g | $65 | 2026-06-03 | Buy |
| TRC | TRC-A617745-50G | 3-Amino-4-chlorobenzoic Acid | 2840-28-0 | 50g | $109 | 2026-06-03 | Buy |
3-Amino-4-chlorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Amino-4-chlorobenzoic Acid is a useful reagent for preparation of novel bis-triazolyl-aryl-benzimidazole-thiol derivatives.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
40872-87-5
2840-28-0
General procedure for the synthesis of 3-amino-4-chlorobenzoic acid from methyl 3-amino-4-chlorobenzoate: to a stirred solution of methyl 3-amino-4-chlorobenzoate (0.300 g, 1.62 mmol) in tetrahydrofuran (20 mL) was added a solution of lithium hydroxide (0.340 g, 8.10 mmol) in water (5 mL). The reaction mixture was stirred at room temperature for 12 hours (the reaction progress was monitored by silica gel thin layer chromatography with ethyl acetate-hexane as the unfolding agent, 1:1, v/v). After completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting lithium salt was acidified with 1% (w/v) citric acid solution at 0 °C and extracted with ethyl acetate (2 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3-amino-4-chlorobenzoic acid as a white solid (yield 0.200 g, 72.01%).
Purification Methods
Crystallise the acid from water. [Beilstein 14 IV 1115.]
References
[1] Patent: US2012/184548, 2012, A1. Location in patent: Page/Page column 43
3-Amino-4-chlorobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9599 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29094 | 58 |
View Lastest Price from 3-Amino-4-chlorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-24 | 3-Amino-4-chlorobenzoic acid
2840-28-0
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-01 | 3-amino-4-chlorobenzoic acid
2840-28-0
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2019-07-06 | 3-Amino-4-chlorobenzoic acid
2840-28-0
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- 3-Amino-4-chlorobenzoic acid
2840-28-0
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-amino-4-chlorobenzoic acid
2840-28-0
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 3-Amino-4-chlorobenzoic acid
2840-28-0
- $1.00
- 99%
- Career Henan Chemical Co
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