DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE
![DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Structure](CAS/GIF/106961-33-5.gif)
- CAS No.
- 106961-33-5
- Chemical Name:
- DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE
- Synonyms
- SKL407;Zolpidem Impurity 67;imidazo[1,2-a]pyridin-3-yl);N,N-Dimethyl-1-(6-methyl-2-(p-tolyl);DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE;Imidazo[1,2-a]pyridine-3-methanamine, N,N,6-trimethyl-2-(4-methylphenyl)-;3-(DiMethylaMinoMethyl)-6-Methyl-2-(4-Methylphenyl)iMidazo[1,2-a]pyridine;N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
- CBNumber:
- CB41011199
- Molecular Formula:
- C18H21N3
- Molecular Weight:
- 279.38
- MDL Number:
- MOL File:
- 106961-33-5.mol
| Product description | Number | Pack Size | Price |
| 3-(Dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine | TRC-D461105-50MG | 50mg | $239 |
| 3-(Dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine | TRC-D461105-500MG | 500mg | $849 |
| N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 97% | D59240 | 100mg | $195 |
| N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 97% | D59240 | 250mg | $212 |
| N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 97% | D59240 | 1g | $220 |
| Melting point | 134 - 139°C |
|---|---|
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 8.30±0.28(Predicted) |
| form | Solid |
| color | White to Pale Yellow |
DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D461105-50MG | 3-(Dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine | 106961-33-5 | 50mg | $239 | 2026-06-03 | Buy |
| TRC | TRC-D461105-500MG | 3-(Dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine | 106961-33-5 | 500mg | $849 | 2026-06-03 | Buy |
| Synthonix | D59240 | N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 97% | 106961-33-5 | 100mg | $195 | 2026-05-06 | Buy |
| Synthonix | D59240 | N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 97% | 106961-33-5 | 250mg | $212 | 2026-05-06 | Buy |
| Synthonix | D59240 | N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 97% | 106961-33-5 | 1g | $220 | 2026-05-06 | Buy |
DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Chemical Properties,Uses,Production
Synthesis
50-00-0
![6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine](/CAS/GIF/88965-00-8.gif)
88965-00-8
124-40-3
![DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE](/CAS/GIF/106961-33-5.gif)
106961-33-5
Step (i): Preparation of N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methylamine (8). Under stirring, 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine (200 g, 0.92 mol) was dissolved in acetic acid (985 mL). The reaction mixture was cooled to 0-5 °C and 40% aqueous dimethylamine (157 g, 1.39 mol) was slowly added followed by paraformaldehyde (36.11 g, 1.20 mol). The reaction mixture was stirred at 50-55°C for 3-4 hours, followed by removal of acetic acid under reduced pressure. Water (1.5 l) was added, the filtrate was filtered through a diatomaceous earth pad and the filtrate was alkalized to pH 8.0-8.5 by dropwise addition of 30% sodium hydroxide solution. filtration afforded an off-white solid, which was washed sequentially with water (500 ml) and hexane (200 ml). The solid was dried to constant weight in an oven to give 230 g of N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methylamine (8) in 91.6% yield and 93.5% purity. Melting point range: 137.9-141.5 °C. IR spectrum (cm^-1): 2944, 2809, 2761, 1502, 1454, 1389, 1018, 829, 799. 1H NMR (400 MHz, CDCl3): δ 2.25 (s, 6H), 2.36 (s, 3H), 2.40 (s, 3H), 3.84 (s, 2H), 7.04 (dd, J = 9.1 Hz, J = 1.6 Hz, 1H), 7.25 (d, J = 7.9 Hz, 2H), 7.52 (d, J = 9.1 Hz, 1H), 7.69 (d, J = 8.0 Hz, 2H), 8.10 (s, 1H). Mass spectrum (m/z): 280.4 (M + H)+.
References
[1] Patent: WO2009/7995, 2009, A1. Location in patent: Page/Page column 11; 13-14; 15-17
[2] Farmaco, 1991, vol. 46, # SUPPL. 1, p. 277 - 288
[3] Acta Poloniae Pharmaceutica - Drug Research, 2001, vol. 58, # 1, p. 43 - 52
[4] Patent: US2007/27180, 2007, A1. Location in patent: Page/Page column title page; sheet 1; 6
DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Qingdao Dexin Chemical Co., Ltd | +86-15553333686 | 15553333686@qq.com | China | 3113 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai Kahn Pharmaceutical Co., Ltd. | 021-34979681; 17701870669 | 41513101@qq.com | China | 1785 | 55 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28768 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15082 | 58 |
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