Benzenamine, 2,6-difluoro-4-methoxy- (9CI)
- CAS No.
- 151414-47-0
- Chemical Name:
- Benzenamine, 2,6-difluoro-4-methoxy- (9CI)
- Synonyms
- 4-Amino-3,5-difluoroanisole;2,6-Difluoro-4-methoxybenzenamine;Benzenamine, 2,6-difluoro-4-methoxy-;Benzenamine, 2,6-difluoro-4-methoxy- (9CI);4-Amino-3,5-difluoroanisole, 2,6-Difluoro-p-anisidine;4-AMino-3,5-difluoroanisole[2,6-Difluoro-4-Methoxyaniline]
- CBNumber:
- CB41045510
- Molecular Formula:
- C7H7F2NO
- Molecular Weight:
- 159.13
- MDL Number:
- MFCD04115922
- MOL File:
- 151414-47-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,6-Difluoro-4-methoxyaniline ≥95% | PC5543 | 1g | $39 |
| 2,6-Difluoro-4-methoxyaniline ≥95% | PC5543 | 5g | $117 |
| 2,6-Difluoro-4-methoxyaniline ≥95% | PC5543 | 10g | $218 |
| 2,6-Difluoro-4-methoxyaniline 98% | AS33415 | 1g | $56 |
| 2,6-Difluoro-4-methoxyaniline 98% | AS33415 | 5g | $149 |
| More product size | |||
| Melting point | 38-40℃ |
|---|---|
| Boiling point | 172.4±35.0 °C(Predicted) |
| Density | 1.281±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.41±0.10(Predicted) |
| Appearance | Off-white to light brown Solid |
| Water Solubility | Insoluble in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H311-H315-H319-H332 | |||||||||
| Precautionary statements | P280h-P305+P351+P338-P309-P310 | |||||||||
| RIDADR | 2810 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2922290090 | |||||||||
| NFPA 704 |
|
Benzenamine, 2,6-difluoro-4-methoxy- (9CI) price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC5543 | 2,6-Difluoro-4-methoxyaniline ≥95% | 151414-47-0 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC5543 | 2,6-Difluoro-4-methoxyaniline ≥95% | 151414-47-0 | 5g | $117 | 2026-06-04 | Buy |
| Apolloscientific | PC5543 | 2,6-Difluoro-4-methoxyaniline ≥95% | 151414-47-0 | 10g | $218 | 2026-06-04 | Buy |
| Activate Scientific | AS33415 | 2,6-Difluoro-4-methoxyaniline 98% | 151414-47-0 | 1g | $56 | 2026-06-04 | Buy |
| Activate Scientific | AS33415 | 2,6-Difluoro-4-methoxyaniline 98% | 151414-47-0 | 5g | $149 | 2026-06-04 | Buy |
Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Chemical Properties,Uses,Production
Uses
2,6-Difluoro-4-methoxyaniline is used as primary and secondary intermediate.
Synthesis
67-56-1
315-14-0
151414-47-0
Example 58A; Synthesis of 2,6-difluoro-4-methoxyaniline; 10 g (56 mmol) of 1,3,5-trifluoro-2-nitrobenzene was dissolved in 250 mL of methanol, and a methanolic solution of 3.36 g (62 mmol) of sodium methanolate (250 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure by rotary evaporator and the residue was hydrolyzed with dilute aqueous hydrochloric acid solution followed by extraction with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and filtered to give the crude product. The crude product was dissolved in 110 mL of methanol, 275 mg of 10% palladium carbon catalyst was added and the hydrogenation reaction was carried out at room temperature overnight. After the reaction, the catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, v/v/v/9:1), resulting in 1.24 g of the target product 2,6-difluoro-4-methoxyaniline in 14% yield. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ=3.66 (s, 3H, OCH3), 4.60 (br.s, 2H, NH2), 6.55-6.70 (m, 2H, ArH).
References
[1] Patent: WO2003/76405, 2003, A1. Location in patent: Page/Page column 85
Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4326 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +86-13336024896 | CB@aromsyn.com | China | 19176 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-13119157289 | 18791163155@163.com | China | 3390 | 58 |
View Lastest Price from Benzenamine, 2,6-difluoro-4-methoxy- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-02-09 | 2,6-Difluoro-4-methoxyaniline
151414-47-0
|
1KG | 97.8% | 100 tons | Honest Joy Holdings Limited
|
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- 2,6-Difluoro-4-methoxyaniline
151414-47-0
- $0.00
- 97.8%
- Honest Joy Holdings Limited
