ChemicalBook >> CAS DataBase List >>(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID structure

CAS No.: 114457-94-2

Chemical Name:: (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID

Synonyms: N-Pyrazinylcarbonyl-L-phenylalanine;N-PyrazinyL;Bortezomib INT;Bortezomib INT B;Bortezomib impurity B;Bortezomib Acid Analog;Bortezomib impurity 92;Antibacterial agent 268;N-(2-pyrazinylcarbonyl)-;Bortezomib Acid Impurity

CBNumber:: CB41119462

Molecular Formula:: C14H13N3O3

Molecular Weight:: 271.27

MDL Number:: MFCD09800536

MOL File:: 114457-94-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:47:49

Product description	Number	Pack Size	Price
N-(Pyrazinylcarbonyl)-L-phenylalanine >98.0%(HPLC)	P2068	1g	$40
N-Pyrazinylcarbonylphenylalanine (3-Phenyl-2-[(pyrazine-2-carbonyl)-amino]-propionic Acid)	P9494-75	250mg	$446
N-Pyrazinylcarbonyl-L-phenylalanine	287137	100mg	$305
N-Pyrazinylcarbonyl-L-phenylalanine	287137	250mg	$410
N-Pyrazinylcarbonyl-L-phenylalanine	287137	500mg	$531
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(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID Properties

Melting point	166-169℃
Boiling point	573.8±50.0 °C(Predicted)
Density	1.323
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol (Sparingly)
pka	13.93±0.46(Predicted)
form	Solid
color	White to Light Beige
Major Application	pharmaceutical small molecule
InChI	InChI=1S/C14H13N3O3/c18-13(12-9-15-6-7-16-12)17-11(14(19)20)8-10-4-2-1-3-5-10/h1-7,9,11H,8H2,(H,17,18)(H,19,20)/t11-/m0/s1
InChIKey	DWYZPDHMMZGQAP-NSHDSACASA-N
SMILES	C(O)(=O)[C@H](CC1=CC=CC=C1)NC(C1=NC=CN=C1)=O
FDA UNII	9R67B83S2T
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933998090

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2068	N-(Pyrazinylcarbonyl)-L-phenylalanine >98.0%(HPLC)	114457-94-2	1g	$40	2026-04-30	Buy
Usbiological	P9494-75	N-Pyrazinylcarbonylphenylalanine (3-Phenyl-2-[(pyrazine-2-carbonyl)-amino]-propionic Acid)	114457-94-2	250mg	$446	2026-06-04	Buy
Usbiological	287137	N-Pyrazinylcarbonyl-L-phenylalanine	114457-94-2	100mg	$305	2026-06-03	Buy
Usbiological	287137	N-Pyrazinylcarbonyl-L-phenylalanine	114457-94-2	250mg	$410	2026-06-03	Buy
Usbiological	287137	N-Pyrazinylcarbonyl-L-phenylalanine	114457-94-2	500mg	$531	2026-06-03	Buy

Product number	Packaging	Price	Buy
P2068	1g	$40	Buy
P9494-75	250mg	$446	Buy
287137	100mg	$305	Buy
287137	250mg	$410	Buy
287137	500mg	$531	Buy

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID Chemical Properties,Uses,Production

Chemical Properties

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID is Light Beige Solid

Uses

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID is used for the synthesis of Bortezomib (B675700) from L-phenylalanine via dipeptidyl boronic acid ester intermediates.

Synthesis

N-Pyrazinylcarbonyl-L-phenylalanine Methyl Ester

73058-37-4

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID

114457-94-2

General procedure for the synthesis of (S)-3-phenyl-2-(pyrazine-2-carboxamido)propionic acid from (pyrazine-2-carbonyl)-L-phenylalanine methyl ester: N-pyrazinecarbonyl-L-phenylalanine methyl ester (1.0 g, 3.51 mmol) was dissolved in 10 mL of acetone, and the pH was adjusted to 12-13 by slowly adding 2N NaOH solution dropwise under cooling in an ice-water bath.Reaction. The progress of the reaction was monitored by thin-layer chromatography (TLC) during the process, and the reaction was completed after 2 hours. Subsequently, hydrochloric acid was slowly added dropwise in an ice-water bath and the pH was adjusted to 2~3, at which time a large amount of white solid precipitated. The precipitate was collected by filtration, washed with water and ether sequentially, and then dried in air. Finally, 0.89 g of white solid product was obtained with a yield of 93.6% and a melting point of 166-169°C. The product structure was analyzed by 1H-NMR. The structure of the product was confirmed by 1H-NMR (DMSO-d6, 300 MHz): δ 3.23 (-CH2, m, 2H), 4.74 (-CH, m, 1H), 7.16-7.25 (-Ph, m, 5H), 8.74 (-CONH, t, 1H), 8.86-8.89 (-Pyz, t, 2H), 9.14 (-Pyz. d, 1H), 13.06 (-COOH, s, 1H).

References

[1] Patent: EP2444411, 2016, B1. Location in patent: Paragraph 0038
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 15, p. 4031 - 4044
[3] Organic and Biomolecular Chemistry, 2007, vol. 5, # 9, p. 1416 - 1426
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 19, p. 6851 - 6861
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4192 - 4199

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID synthesis

Synthesis of (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID from N-Pyrazinylcarbonyl-L-phenylalanine Methyl Ester

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID Preparation Products And Raw materials

Raw materials

sodium 3-phenyl-L-alaninate Isopropyl L-phenylalaninate hydrochloride(L-phenylalanine SilaCO - (Methyl(diphenyl)silyl)formic acid 2-PYRAZINECARBONYL CHLORIDE Methanone, 1H-imidazol-1-yl-2-pyrazinyl-

methyl 3-phenyl-L-alaninate N-Pyrazinylcarbonyl-L-phenylalanine Methyl Ester N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester tert-Butyl 3-phenyl-L-alaninate hydrochloride Iodopyrazine

Methyl L-phenylalaninate hydrochloride 2-Pyrazinecarboxylic acid L-Phenylalanine

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Preparation Products

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID Suppliers

Global( 343)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd		sarah@tnjone.com	China	1143	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8618017249410	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58

Supplier	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58

View Lastest Price from (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-31	(S)-3-phenyl-2-(pyrazine-2-carboxamido)propanoic acid 114457-94-2		1KG	99%min	1000 KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-06	N-(Pyrazinylcarbonyl)-L-phenylalanine 114457-94-2			99.85%	10g	TargetMol Chemicals Inc.
2025-05-23	(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID 114457-94-2	$10.00	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd

(S)-3-phenyl-2-(pyrazine-2-carboxamido)propanoic acid
114457-94-2
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

N-(Pyrazinylcarbonyl)-L-phenylalanine
114457-94-2
$0.00
99.85%
TargetMol Chemicals Inc.

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID
114457-94-2
$10.00
99%
Hebei Zhuanglai Chemical Trading Co Ltd

114457-94-2((S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID)Related Search:

Palladium (II) Acetate Ufiprazole Sildenafil citrate 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- L-Phenylalanine

Phosphorus trichloride BortezoMib IMpurity N Bortezomib Impurity 5 1-Chloro-2-methylpropane Bortezomib Impurity 45

BOC-D-Phenylalanine N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Sildenafil ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Bortezomib

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(S)-3-Phenyl-2-[(pyrazine-2-carbonyl)-amino]-propionic acid Bortezomib Intermediate 2 N-(2-Pyrazinylcarbonyl)-L-phenylalanine Bortezomib Acid Impurity Bortezomib INT B N-(Pyrazinylcarbonyl)-L-phenylalanine (S)-3-Phenyl-2-(pyrazine-2-carboxaMido)propanoic acid N-(2-pyrazinylcarbonyl)- BortezoMib IMpurity B ((S)-3-Phenyl-2-(pyrazine-2-carbonylaMino)propanoic Acid) L-Phenylalanine, N-(2-pyrazinylcarbonyl)- Bortezomib impurity B Bortezomib INT Bortezomib impurity 12/((S)-3-Phenyl-2-(pyrazine-2-carbonylamino)propanoic Acid (2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanoic acid (pyrazine-2-carbonyl)-L-phenylalanine (S)-3-Phenyl-2-(pyrazine-2-carbox 2-[[oxo(2-pyrazinyl)methyl]amino]-3-phenylpropanoic acid N-PyrazinyL Bortezomib USP Impurity D N-((S)-1-(((S)-3-methyl-1-((3aR,4R,6R,7aS)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3- phenylpropan-2-yl)pyrazine-2-carboxamide (S)-3-Phenyl-2-[[(pyrazin-2-yl)carbonyl]amino]propanoic acid (Bortezomib Impurity) Bortezomib Related Compund D/ Bortezomib Acid Analog (R)-3-methyl-1-((3aS,4S,6S,7aS)-3a,5,5- trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1- amine Bortezomib Acid Analog (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID (S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoicaci (S)-3-phenyl-2-(pyrazine-5-carboxamido)propanoic acid (S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoic acid|||N-(Pyrazinylcarbonyl)-L-phenylalanine Bortezomib impurity 92 Antibacterial agent 268 (S)-3-Phenyl-2-[(pyrazine-2-carbonyl)amino]propanoicacid (S)-3-Phenyl-2-(pyrazine-2-carboxcarboxamido)-propanoic acid N-Pyrazinylcarbonyl-L-phenylalanine 114457-94-2 114459-94-2 1144557-94-2 Amino Acids & Derivatives Aromatics

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