Methyl 5-formyl-2-methoxybenzoate
- CAS No.
- 78515-16-9
- Chemical Name:
- Methyl 5-formyl-2-methoxybenzoate
- Synonyms
- EOS-61914;Methoxy ester;Eluxadoline int4;Eluxadoline Intermediate 3;5-formyl-2-methoxybenzamide;methyl5-formyl-2-methoxybenzoate;4-Methoxy-3-methoxycarbonylbenzaldehyde;5-Formyl-2-methoxybenzoic Acid Methyl Ester;5-Formyl-2-methoxyl-benzoic acid methyl ester;Eluxadoline: Methyl 5-formyl-2-methoxybenzoate
- CBNumber:
- CB41456990
- Molecular Formula:
- C10H10O4
- Molecular Weight:
- 194.18
- MDL Number:
- MFCD10565654
- MOL File:
- 78515-16-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 5-Formyl-2-methoxybenzoate min. 98.0 % | M3327 | 5G | $79 |
| Methyl 5-Formyl-2-methoxybenzoate min. 98.0 % | M3327 | 25G | $238 |
| Methyl 5-Formyl-2-methoxybenzoate | 455719 | 1g | $340 |
| Methyl 5-Formyl-2-methoxybenzoate | 455719 | 5g | $496 |
| Methyl 5-formyl-2-methoxybenzoate >98% | OR951320 | 5g | $21 |
| More product size | |||
| Melting point | 86-87 °C |
|---|---|
| Boiling point | 163-165 °C(Press: 1 Torr) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H10O4/c1-13-9-4-3-7(6-11)5-8(9)10(12)14-2/h3-6H,1-2H3 |
| InChIKey | CNRMXICSYWVJRD-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC(C=O)=CC=C1OC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2918999090 |
Methyl 5-formyl-2-methoxybenzoate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3327 | Methyl 5-Formyl-2-methoxybenzoate min. 98.0 % | 78515-16-9 | 5G | $79 | 2026-04-30 | Buy |
| TCI Chemical | M3327 | Methyl 5-Formyl-2-methoxybenzoate min. 98.0 % | 78515-16-9 | 25G | $238 | 2026-04-30 | Buy |
| Usbiological | 455719 | Methyl 5-Formyl-2-methoxybenzoate | 78515-16-9 | 1g | $340 | 2026-06-03 | Buy |
| Usbiological | 455719 | Methyl 5-Formyl-2-methoxybenzoate | 78515-16-9 | 5g | $496 | 2026-06-03 | Buy |
| Apolloscientific | OR951320 | Methyl 5-formyl-2-methoxybenzoate >98% | 78515-16-9 | 5g | $21 | 2026-06-04 | Buy |
Methyl 5-formyl-2-methoxybenzoate Chemical Properties,Uses,Production
Chemical Properties
White to Almost white powder to crystaline; Melting Point 87 °C.
Uses
Methyl 5-Formyl-2-methoxybenzoate is an intermediate used to synthesize peroxisome proliferator-activated receptor (PPAR) activators. It is also used to prepare 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene derivatives as PTP1B inhibitors.
Synthesis
616-76-2
74-88-4
78515-16-9
General procedure for the synthesis of methyl 5-formyl-2-methoxybenzoate from 5-formyl-2-hydroxybenzoic acid and iodomethane: 5-formyl-2-hydroxybenzoic acid (2.0 g, 12.0 mmol), iodomethane (1.5 mL, 25 mmol) and potassium carbonate (3.06 g, 22.2 mmol) were mixed in dimethylformamide (15 mL). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in ethyl acetate, washed sequentially with water (2×), saturated saline (2×) and the organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the resulting residue was purified by column chromatography to afford the target product methyl 5-formyl-2-methoxybenzoate 1.85 g (79% yield). The structure of the product was confirmed by 1H-NMR (CDCl3, 500 MHz) and mass spectrometry: 1H-NMR δ 9.91 (s, 1H), 8.31 (d, J = 2.1 Hz, 1H), 8.02 (dd, J = 8.5, 2.5 Hz, 1H), 7.11 (d, J = 8.6 Hz, 1H), 3.99 (s, 3H), 3.91 (s, 3H); mass spectrometry: 195 (s, 3H); mass spectrometry: 196 (s, 3H); mass spectrometry: 196 (s, 3H). 3H); MS: 195.05 (MH)+.
References
[1] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 65; 67; 69
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 2, p. 313 - 316
[3] European Journal of Medicinal Chemistry, 2004, vol. 39, # 7, p. 573 - 578
[4] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 114
[5] Patent: WO2014/202528, 2014, A1. Location in patent: Page/Page column 108; 109
Methyl 5-formyl-2-methoxybenzoate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SyncoZymes (Shanghai) Co., Ltd., | +8613681683526 | lchen@syncozymes.com | China | 286 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
| Synbest Biotech(Hangzhou) Co., Ltd | 86-571-88737065 | sales@synbestech.com | CHINA | 170 | 58 |
View Lastest Price from Methyl 5-formyl-2-methoxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-01 | Methyl 5-formyl-2-methoxybenzoate
78515-16-9
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-07-13 | Methyl 5-formyl-2-methoxybenzoate
78515-16-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-09 | Methyl 5-formyl-2-methoxybenzoate
78515-16-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Methyl 5-formyl-2-methoxybenzoate
78515-16-9
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Methyl 5-formyl-2-methoxybenzoate
78515-16-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Methyl 5-formyl-2-methoxybenzoate
78515-16-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
