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ChemicalBook >> CAS DataBase List >>2-ACETAMIDO-5-NITROTHIAZOLE

2-ACETAMIDO-5-NITROTHIAZOLE

CAS No.
140-40-9
Chemical Name:
2-ACETAMIDO-5-NITROTHIAZOLE
Synonyms
CL 5279;Gynofon;Nitasol;Nitazol;CL 5,279;Nitazole;Pleocide;Tricogen;Tricoral;Tritheon
CBNumber:
CB4156271
Molecular Formula:
C5H5N3O3S
Molecular Weight:
187.18
MDL Number:
MFCD00022438
MOL File:
140-40-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-29 19:27:05
Product description Number Pack Size Price
2-ACETAMIDO-5-NITROTHIAZOLE AldrichCPR S540846 1 unit $197
2-ACETAMIDO-5-NITROTHIAZOLE Aldrich S540846 250mg $179
2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T) A0689 1g $77
2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T) A0689 5g $196
Nithiamide ≥95% 36006 1g $99

2-ACETAMIDO-5-NITROTHIAZOLE Properties

Melting point 263°C (dec.)
Boiling point 421°
Density 1.546 (estimate)
refractive index 1.6560 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMF:3.0(Max Conc. mg/mL);16.03(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);53.43(Max Conc. mM)
form solid
pka 8.78±0.50(Predicted)
color White to Amber
Merck 14,410
BRN 167361
InChI InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)
InChIKey UJRRDDHEMZLWFI-UHFFFAOYSA-N
SMILES C(NC1=NC=C([N+]([O-])=O)S1)(=O)C
CAS DataBase Reference 140-40-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 9CBM60191Z

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS02,GHS07,GHS06
Signal word  Warning
Hazard statements  H228-H302+H312+H332-H302-H301
Precautionary statements  P301+P310a-P321-P405-P501a-P210-P240-P241-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-36/37-24/25
RTECS  XJ1570000
HS Code  29341000
Toxicity chicken,LD50,oral,800mg/kg (800mg/kg),Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
NFPA 704
1
2 0

2-ACETAMIDO-5-NITROTHIAZOLE price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S540846 2-ACETAMIDO-5-NITROTHIAZOLE AldrichCPR 140-40-9 1 unit $197 2026-04-30 Buy
Sigma-Aldrich S540846 2-ACETAMIDO-5-NITROTHIAZOLE Aldrich 140-40-9 250mg $179 2024-03-01 Buy
TCI Chemical A0689 2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T) 140-40-9 1g $77 2026-04-30 Buy
TCI Chemical A0689 2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T) 140-40-9 5g $196 2026-04-30 Buy
Cayman Chemical 36006 Nithiamide ≥95% 140-40-9 1g $99 2026-04-30 Buy
Product number Packaging Price Buy
S540846 1 unit $197 Buy
S540846 250mg $179 Buy
A0689 1g $77 Buy
A0689 5g $196 Buy
36006 1g $99 Buy

2-ACETAMIDO-5-NITROTHIAZOLE Chemical Properties,Uses,Production

Chemical Properties

Yellow-brown solid

Uses

Nithiamide is a drug for chemotherapy. A protistocide drug with antibacterial activity.

Uses

antiinflammatory, glucocorticoid

Definition

ChEBI: Aminitrozole is an aromatic amide and a member of acetamides.

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and NOx,.

Synthesis

2-Amino-5-nitrothiazole

121-66-4

Acetic anhydride

108-24-7

2-ACETAMIDO-5-NITROTHIAZOLE

140-40-9

General method: 2-amino-5-nitrothiazole (0.3 g, 2.0 mmol) was dissolved in dichloromethane, followed by the addition of 1.2 molar equivalents of triethylamine (TEA). The reaction mixture was stirred at 5 °C for 15 min, then acetic anhydride (10.0 mmol, 5 eq.) or the corresponding chloride (2.2 mmol, 1.1 eq.) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 4 to 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue is neutralized with saturated sodium bicarbonate (NaHCO3) solution and the resulting solid is purified by recrystallization from the appropriate solvent mixture.

Purification Methods

Recrystallise acinitrazole from EtOH or AcOH. [Hurd & Wehrmeister J Am Chem Soc 71 4007 1949, Beilstein 27 III/IV 4676.]

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 5, p. 1626 - 1633

2-ACETAMIDO-5-NITROTHIAZOLE Preparation Products And Raw materials

2-ACETAMIDO-5-NITROTHIAZOLE Suppliers

Global( 165)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3992 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30225 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9071 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Henan Alfa Chemical Co., Ltd 		+8615838112936 sale03@alfachem.cn China 9796 58

View Lastest Price from 2-ACETAMIDO-5-NITROTHIAZOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nithiamide pictures 2026-05-29 Nithiamide
140-40-9
 $29.00 99.77% 10g TargetMol Chemicals Inc.
Nithiamide pictures 2026-05-29 Nithiamide
140-40-9
 $29.00 99.77% 10g TargetMol Chemicals Inc.
2-ACETAMIDO-5-NITROTHIAZOLE pictures 2025-12-24 2-ACETAMIDO-5-NITROTHIAZOLE
140-40-9
 1KG 99.0% 1000KG Shaanxi Dideu Medichem Co. Ltd
  • Nithiamide pictures
  • Nithiamide
    140-40-9
  • $29.00
  • 99.77%
  • TargetMol Chemicals Inc.
  • Nithiamide pictures
  • Nithiamide
    140-40-9
  • $29.00
  • 99.77%
  • TargetMol Chemicals Inc.
AKOS AU36-M376 2-ACETYLAMINO-5-NITROTHIAZOLE 2-ACETAMINO-5-NITROTHIAZOLE 2-ACETAMIDO-5-NITROTHIAZOLE N-(5-NITRO-2-THIAZOLYL)ACETAMIDE 2-acetamido-5-nitro-thiazol 5-Nitro-2-acetamidothiazole 5-Nitro-2-acetilaminotiazolo Acetamide, N-(5-nitro-2-thiazolyl)- Acetyl enheptin acetylenheptin Acinitrazol Acinitrazole Ametoterina Aminitrazol Aminitrazole Aminitrozol Aminitrozole Aminitrozolum CL 5,279 CL 5279 Cyzine Premix DINITOLMIDE SOLUTION 100 NG/5L IN ACETO 2-ACETAMIDO-5-NITROTHIAZOLE 97+% N-(5-nitro-1,3-thiazol-2-yl)ethanamide cyzinepremix Enheptin A enheptina Gynofon Lavoflagin N-(5-Nitro-1,3-thiazol-2-yl)acetamide n-(5-nitro-2-thiazolyl)-acetamid Nitasol Nitazol Nitazole Nithiamide Pleocide Thiazole, 2-acetamido-5-nitro- Trichlorad Trichloral Trichocid Trichoman Trichorad Trichoral Tricogen Tricolaval Tricoral Tricosteril Trikolaval Tritheon N-(5-nitrothiazol-2-yl)acetamide 2-Acetamido-5-nitrothiazole > 2-Acetylamino-5-nitrothiazole Standard 2-Acetamido-5-nitrothiazole, ≥ 98.0% C10012500 2-Acetamido-5-nitrothiazole Lurasidone Impurity 104 Nithiamide, 10 mM in DMSO Nithiamide (Standard)
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