DL-BUTHIONINE-[S,R]-SULFOXIMINE
![DL-BUTHIONINE-[S,R]-SULFOXIMINE Structure](CAS/GIF/5072-26-4.gif)
- CAS No.
- 5072-26-4
- Chemical Name:
- DL-BUTHIONINE-[S,R]-SULFOXIMINE
- Synonyms
- buthioninesulfoximine;NSC 381100;butioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;
DL -Buthionine-sulfoximine
- CBNumber:
- CB4184630
- Molecular Formula:
- C8H18N2O3S
- Molecular Weight:
- 222.31
- MDL Number:
- MFCD00070309
- MOL File:
- 5072-26-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| DL-Buthionine-sulfoximine ≥99.0% (TLC) | 19176 | 1g | $365 |
| DL-Buthionine-sulfoximine ≥99.0% (TLC) | 19176 | 5g | $1260 |
| D,L-Buthionine-(S,R)-Sulfoximine ≥95% | 23691 | 250mg | $82 |
| D,L-Buthionine-(S,R)-Sulfoximine ≥95% | 23691 | 500mg | $156 |
| D,L-Buthionine-(S,R)-Sulfoximine ≥95% | 23691 | 1g | $293 |
| Melting point | 215 °C (dec.)(lit.) |
|---|---|
| Boiling point | 382.3±52.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | Fluffy Powder |
| color | White |
| biological source | synthetic (organic) |
| Water Solubility | water: 50mg/mL, clear to very slightly hazy, colorless to yellow |
| Merck | 13,1520 |
| BRN | 2367136 |
| InChI | 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12) |
| InChIKey | KJQFBVYMGADDTQ-UHFFFAOYSA-N |
| SMILES | CCCCS(=N)(=O)CCC(N)C(O)=O |
| CAS DataBase Reference | 5072-26-4(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | buthionine sulfoximine |
| FDA UNII | LW4108Q0BV |
| NCI Drug Dictionary | buthionine sulfoximine |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EK7713435 | |||||||||
| F | 10 | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
DL-BUTHIONINE-[S,R]-SULFOXIMINE price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 19176 | DL-Buthionine-sulfoximine ≥99.0% (TLC) | 5072-26-4 | 1g | $365 | 2026-04-30 | Buy |
| Sigma-Aldrich | 19176 | DL-Buthionine-sulfoximine ≥99.0% (TLC) | 5072-26-4 | 5g | $1260 | 2026-04-30 | Buy |
| Cayman Chemical | 23691 | D,L-Buthionine-(S,R)-Sulfoximine ≥95% | 5072-26-4 | 250mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 23691 | D,L-Buthionine-(S,R)-Sulfoximine ≥95% | 5072-26-4 | 500mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 23691 | D,L-Buthionine-(S,R)-Sulfoximine ≥95% | 5072-26-4 | 1g | $293 | 2026-04-30 | Buy |
DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
DL-Buthionine-sulfoximine is suitable for use to:
- examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
- investigate the effect of BSO on development of bovine embryos
- inhibit GSH in several studies
- investigate the effect of GSH synthesis on oocyte maturation
Uses
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Uses
Biological tool for depletion of glutathione.
Definition
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
General Description
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).
DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials
Raw materials
Preparation Products
DL-BUTHIONINE-[S,R]-SULFOXIMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
View Lastest Price from DL-BUTHIONINE-[S,R]-SULFOXIMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | DL-Buthionine-(S,R)-sulfoximine
5072-26-4
|
$33.00 | 99.76% | 10g | TargetMol Chemicals Inc. |
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- DL-Buthionine-(S,R)-sulfoximine
5072-26-4
- $33.00
- 99.76%
- TargetMol Chemicals Inc.
