4-CHLORO-5-NITROQUINOLINE
- CAS No.
- 40106-98-7
- Chemical Name:
- 4-CHLORO-5-NITROQUINOLINE
- Synonyms
- 4-CHLORO-5-NITROQUINOLINE;Quinoline, 4-chloro-5-nitro-
- CBNumber:
- CB42449362
- Molecular Formula:
- C9H5ClN2O2
- Molecular Weight:
- 208.6
- MDL Number:
- MFCD09261099
- MOL File:
- 40106-98-7.mol
| Product description | Number | Pack Size | Price |
| 4-Chloro-5-nitroquinoline 98% | AA00CKVR | 50mg | $41 |
| 4-Chloro-5-nitroquinoline 98% | AA00CKVR | 100mg | $60 |
| 4-Chloro-5-nitroquinoline 98% | AA00CKVR | 250mg | $100 |
| 4-Chloro-5-nitroquinoline 98% | AA00CKVR | 1g | $200 |
| 4-Chloro-5-nitroquinoline 97.00% | Y220566 | 250MG | $155 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-CHLORO-5-NITROQUINOLINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00CKVR | 4-Chloro-5-nitroquinoline 98% | 40106-98-7 | 50mg | $41 | 2026-05-28 | Buy |
| aablocks | AA00CKVR | 4-Chloro-5-nitroquinoline 98% | 40106-98-7 | 100mg | $60 | 2026-05-28 | Buy |
| aablocks | AA00CKVR | 4-Chloro-5-nitroquinoline 98% | 40106-98-7 | 250mg | $100 | 2026-05-28 | Buy |
| aablocks | AA00CKVR | 4-Chloro-5-nitroquinoline 98% | 40106-98-7 | 1g | $200 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y220566 | 4-Chloro-5-nitroquinoline 97.00% | 40106-98-7 | 250MG | $155 | 2026-05-27 | Buy |
4-CHLORO-5-NITROQUINOLINE Chemical Properties,Uses,Production
Synthesis
611-35-8
40106-98-7
23833-99-0
General procedure for the synthesis of 4-chloro-8-nitroquinoline (6a) and 4-chloro-5-nitroquinoline (6d) from 4-chloroquinoline: 1. 4-Chloroquinoline (10.0 g, 61.3 mmol) was added in batches to sulfuric acid (45 mL) at a controlled temperature not exceeding 15°C. 2. cool the reaction solution to -5°C and maintain that temperature. 3. Slowly add fuming nitric acid (9 mL). 4. Gradually warm the reaction mixture to room temperature and continue stirring for 3 hours. 5. Pour the reaction mixture into ice water and adjust the pH to 9 with NH4OH. 6. The precipitate was collected by filtration, washed well with water, dried and recrystallized from methanol to give 7.5 g (59%) of 4-chloro-8-nitroquinoline (6a) as golden-brown acicular crystals with a melting point of 128-129 °C (literature value 129-130 °C). 1H NMR (CDCl3) δ: 7.67 (d, 1H, J=4.5 Hz), 7.75 (dd, 1H, J=8.6 Hz, J=7.6 Hz), 8.10 (dd, 1H, J=7.6 Hz, J=1.3 Hz), 8.48 (dd, 1H, J=8.6 Hz, J=1.3 Hz), 8.94 (d, 1H, J= 4.5 Hz); 13C NMR (CDCl 13C NMR (CDCl3) δ: 123.0, 124.4, 126.5, 127.5, 128.3, 140.6, 143.2, 148.7, 152.1. 7. The mother liquor was concentrated and separated by silica gel column chromatography (eluent: hexane-ethyl acetate = 19:1) to afford 2.05 g (16%) of 4-chloro-5-nitroquinoline (6d) as a very pale yellow solid with a melting point of 144-146 °C (literature value 150 °C). 1H NMR (CDCl3) δ: 7.65 (d, 1H, J=4.7 Hz), 7.82 (m, 2H), 8.35 (dd, 1H, J=2.5 Hz, J=7.3 Hz), 8.90 (d, 1H, J=4.7 Hz). 13C NMR (CDCl3) δ: 118.2, 123.4, 125.1, 128.8, 134.2, 135.6, 139.1, 149.7, 151.2.
References
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 13, p. 3731 - 3742
[2] Patent: WO2004/14906, 2004, A2. Location in patent: Page 31
[3] Journal of the American Chemical Society, 1946, vol. 68, p. 1532,1534
[4] Journal of the Chemical Society, 1948, p. 1707
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 303,306
4-CHLORO-5-NITROQUINOLINE Preparation Products And Raw materials
4-CHLORO-5-NITROQUINOLINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 17321281695 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 13651849907; | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443 | tongbenwan22@163.com | China | 1976 | 55 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15491 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4191 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19778 | 58 | |
| Zhejiang Lianshuo Biotechnology Co., Ltd. | 18616526224 | lianshuo@vip.126.com | China | 9607 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20009 | 58 |
