tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
- CAS No.
- 860436-57-3
- Chemical Name:
- tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Synonyms
- 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline;tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate;tert-butyl 6-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;6-Methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-methoxy-, 1,1-dimethylethyl ester
- CBNumber:
- CB42473420
- Molecular Formula:
- C15H21NO3
- Molecular Weight:
- 263.33
- MDL Number:
- MOL File:
- 860436-57-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline ≥95% | M75165 | 250mg | $185 |
| 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline ≥95% | M75165 | 1g | $410 |
| 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline ≥95% | M75165 | 5g | $1130 |
| tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate >95% | AA00GZLL | 1mg | $213 |
| tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate >95% | AA00GZLL | 5mg | $228 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | M75165 | 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline ≥95% | 860436-57-3 | 250mg | $185 | 2026-05-06 | Buy |
| Synthonix | M75165 | 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline ≥95% | 860436-57-3 | 1g | $410 | 2026-05-06 | Buy |
| Synthonix | M75165 | 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline ≥95% | 860436-57-3 | 5g | $1130 | 2026-05-06 | Buy |
| aablocks | AA00GZLL | tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate >95% | 860436-57-3 | 1mg | $213 | 2026-05-28 | Buy |
| aablocks | AA00GZLL | tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate >95% | 860436-57-3 | 5mg | $228 | 2026-05-28 | Buy |
tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Chemical Properties,Uses,Production
Synthesis
50-00-0
24424-99-5
2039-67-0
860436-57-3
1. 3-Methoxyphenethylamine (1.0 eq.) and MgSO4 (3.0 eq.) were suspended in anhydrous CH2Cl2, followed by batch addition of paraformaldehyde (5.0 eq.). After stirring for 2 hours, the solids were removed by filtration and the filtrate was concentrated. 2. The residue was dissolved in anhydrous trifluoroacetic acid and refluxed overnight under nitrogen protection. After completion of the reaction, the mixture was poured into an ice-water mixture, the aqueous phase was adjusted to alkaline with 6 M NaOH and extracted with CH2Cl2. The organic phase was dried over MgSO4 and concentrated. 3. The remaining oil was dissolved in anhydrous DMF and di-tert-butyl dicarbonate (1.2 eq.) and triethylamine (3.0 eq.) were added. The mixture was stirred for 3 h and concentrated, the residue was dissolved in ethyl acetate and washed with saturated Na2CO3 solution. The organic phase was dried over MgSO4 and concentrated. 4. Purification by fast column chromatography (silica gel, gradient elution, petroleum ether solution with 10-30% EtOAc) afforded tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate in 47% yield. 5. Concentrated HNO3 (1.5 eq.) was added to acetic anhydride (6 eq.) at -20°C under nitrogen protection, and the solution was subsequently added to a nitromethane solution of tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate. The reaction mixture was stirred at -20°C for 3 hours before toluene was added, washed with saturated NaHCO3 solution and brine, dried (MgSO4) and concentrated. 6. Purification by fast column chromatography (silica gel, petroleum ether solution with gradient elution of 20-50% EtOAc) gives a 1:1 mixture of nitration products 3a and 3b in 66% yield. 7. The amine 3a or 3b was dissolved in 48% HBr aqueous solution, refluxed for 12 h and concentrated to dryness to quantitatively obtain the hydrobromide salt of 4a or 4b. 8. Amine 4a or 4b (1 eq.) was dissolved in anhydrous DMF, triethylamine (3 eq.) was added, stirred for 15 min and then 2-(4-chlorophenyl)ethyl isothiocyanate (1.2 eq.) was added. The mixture was stirred for 5 h and concentrated, the residue was dissolved in EtOAc, washed with water, the organic phase was dried (MgSO4) and concentrated. 9. Purification by fast column chromatography (silica gel, petroleum ether:EtOAc (3:2)) afforded N-[2-(4-chlorophenyl)ethyl]-6-hydroxy-7-nitro-3,4-dihydroisoquinoline-2(1H)-thiocarboxamide (Res-14-54) in 76% yield or purification by (silica gel, CH2Cl2:petroleum ether (8:2)) afforded N-[ 2-(4-chlorophenyl)ethyl]-6-hydroxy-5-nitro-3,4-dihydroisoquinoline-2(1H)-carbothioamide (Res-14-56) in 40% yield.
References
[1] Patent: WO2007/11290, 2007, A1. Location in patent: Page/Page column 25-26
tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39021 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11598 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4267 | 65 | |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 2000 | 58 |
| Nantong Bosu Pharmaceutical Technology Co., Ltd. | 0513-51005092; 15962844273 | tashiyxy@163.com | China | 912 | 58 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3743 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16676 | 50 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4987 | 55 |
