5-cyano-2-fluorobenzene-1-sulfonyl chloride
- CAS No.
- 1101120-80-2
- Chemical Name:
- 5-cyano-2-fluorobenzene-1-sulfonyl chloride
- Synonyms
- 5-Cyano-2-fluorobenzenesulfonyl chloride;Benzenesulfonyl chloride, 5-cyano-2-fluoro-;2-Fluoro-5-cyanobenzene-1-sulfonyl chloride;5-cyano-2-fluorobenzene-1-sulfonyl chloride
- CBNumber:
- CB42609984
- Molecular Formula:
- C7H3ClFNO2S
- Molecular Weight:
- 219.62
- MDL Number:
- MFCD18394026
- MOL File:
- 1101120-80-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Cyano-2-fluorobenzene-1-sulfonyl chloride 95% | PC903871 | 500mg | $166 |
| 5-Cyano-2-fluorobenzene-1-sulfonyl chloride 95% | PC903871 | 500mg | $166 |
| 5-Cyano-2-fluorobenzene-1-sulfonyl chloride | 119800 | 1.00g | $61 |
| 5-Cyano-2-fluorobenzene-1-sulfonyl chloride | 119800 | 5.00g | $307 |
| 5-Cyano-2-fluorobenzene-1-sulfonyl chloride | 119800 | 25.00g | $1066 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
| HS Code | 2904990090 |
5-cyano-2-fluorobenzene-1-sulfonyl chloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC903871 | 5-Cyano-2-fluorobenzene-1-sulfonyl chloride 95% | 1101120-80-2 | 500mg | $166 | 2026-06-04 | Buy |
| Apolloscientific | PC903871 | 5-Cyano-2-fluorobenzene-1-sulfonyl chloride 95% | 1101120-80-2 | 500mg | $166 | 2026-06-04 | Buy |
| Matrix Scientific | 119800 | 5-Cyano-2-fluorobenzene-1-sulfonyl chloride | 1101120-80-2 | 1.00g | $61 | 2026-05-18 | Buy |
| Matrix Scientific | 119800 | 5-Cyano-2-fluorobenzene-1-sulfonyl chloride | 1101120-80-2 | 5.00g | $307 | 2026-05-18 | Buy |
| Matrix Scientific | 119800 | 5-Cyano-2-fluorobenzene-1-sulfonyl chloride | 1101120-80-2 | 25.00g | $1066 | 2026-05-18 | Buy |
5-cyano-2-fluorobenzene-1-sulfonyl chloride Chemical Properties,Uses,Production
Synthesis
859855-53-1
1101120-80-2
General procedure for the synthesis of 2-fluoro-5-cyanobenzenesulfonyl chloride from 3-amino-4-fluorobenzonitrile: An aqueous solution (2 mL) of NaNO2 (380 mg, 5.51 mmol) was slowly added to a suspension of 3-amino-4-fluorobenzonitrile (500 mg, 3.67 mmol) in concentrated HCl (5 mL) at 0 °C. The reaction mixture was kept stirred at 0 °C for 30 min. Meanwhile, SO2-saturated AcOH solution (5 mL) was prepared, followed by the addition of CuCl2-2H2O (188 mg, 1.10 mmol) and continued to pass SO2 gas for 5 min. This AcOH mixture was cooled to 5 °C and then the diazonium salt solution prepared as previously described was added over 5 min. The reaction mixture was continued to be stirred at 0°C for 1 hour, followed by warming up to room temperature and stirring for another 1 hour. After completion of the reaction, the mixture was diluted with water and extracted twice with CH2Cl2. The organic phases were combined, washed twice with water, dried over Na2SO4 and concentrated under reduced pressure to remove the solvent. Purification by column chromatography (eluent: hexane/EtOAc, 19:1 to 9:1 gradient elution) afforded 2-fluoro-5-cyanobenzenesulfonyl chloride as a yellow oil (569 mg, 71% yield).1H NMR (400 MHz, CDCl3) δ 8.31 (dd, J = 6.2, 2.1 Hz, 1H), 8.04 (dd, J = 8.7, 4.3, 2.1 Hz), 8.04 (ddd, J = 8.7, 4.3, 2.1 Hz). 4.3, 2.1 Hz, 1H), 7.51 (t, J = 8.7 Hz, 1H).LCMS (APCI-) m/z 200 ([M-Cl+O]-, 100%).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 2, p. 187 - 190
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 32 - 40
5-cyano-2-fluorobenzene-1-sulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
