UPF 648
- CAS No.
- 213400-34-1
- Chemical Name:
- UPF 648
- Synonyms
- DBCC;UPF648;UPF 648;UPF648,UPF 648;(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 2-(3,4-dichlorobenzoyl)-, (1S,2S)-
- CBNumber:
- CB42667175
- Molecular Formula:
- C11H8Cl2O3
- Molecular Weight:
- 259.09
- MDL Number:
- MOL File:
- 213400-34-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| UPF-648 ≥98% | 32860 | 1mg | $65 |
| UPF-648 ≥98% | 32860 | 5mg | $248 |
| UPF-648 ≥98% | 32860 | 10mg | $401 |
| UPF 648 | NIA40034 | 5mg | $584.7 |
| UPF 648 | NIA40034 | 10mg | $935.5 |
| Boiling point | 461.3±45.0 °C(Predicted) |
|---|---|
| Density | 1.556±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A solid |
| pka | 3.89±0.11(Predicted) |
| color | White to off-white |
| InChI | 1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 |
| InChIKey | ZBRKMOHDGFGXLN-BQBZGAKWSA-N |
| SMILES | O=C(O)[C@@H]1[C@H](C1)C(C2=CC=C(C(Cl)=C2)Cl)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
UPF 648 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 32860 | UPF-648 ≥98% | 213400-34-1 | 1mg | $65 | 2026-04-30 | Buy |
| Cayman Chemical | 32860 | UPF-648 ≥98% | 213400-34-1 | 5mg | $248 | 2026-04-30 | Buy |
| Cayman Chemical | 32860 | UPF-648 ≥98% | 213400-34-1 | 10mg | $401 | 2026-04-30 | Buy |
| Biosynth | NIA40034 | UPF 648 | 213400-34-1 | 5mg | $584.7 | 2026-06-04 | Buy |
| Biosynth | NIA40034 | UPF 648 | 213400-34-1 | 10mg | $935.5 | 2026-06-04 | Buy |
UPF 648 Chemical Properties,Uses,Production
Uses
UPF-648 is a kynurenine 3-monooxygenase (KMO) inhibitor. KMO is a key enzyme that is part of the kynurenine pathway, which is a metabolic pathway that utilizes tryptophan to produce nicotinamide adenine dinucleotide (NAD+). KMO is a potential therapeutic target for treating neurodegenerative and psychiatric disorders.
Biological Activity
UPF-648 is a potent, active site-targeting kynurenine 3-monooxygenase (KMO; kynurenine 3-hydroxylase) inhibitor (IC50 = 20 nM) th at prevents productive binding of the substrate L-kynurenine by perturbing the local active-site structure. UPF-648 protects against neurodegeneration in a murine (30 mg/kg, i.p.) and a Drosophila (100 μM in maize media) model of Huntingtonμs disease by shifting kynurenine pathway metabolism towards enhanced neuroprotective kynurenic acid (KYNA) formation and away from the free radicals generator 3-hydroxykynurenine (3-HK) and the excitotoxic quinolinic acid (QUIN).
in vivo
Applying an identical experimental design, separate rats were used to study the effect of KMO inhibition on the de novo synthesis of KP metabolites in the lesioned striatum. These animals were bilaterally injected with 0.1 mM UPF 648 and 3H-kynurenine in PBS. 0.1 mM UPF 648 significantly reduced the neosynthesis of 3-HK and QUIN in the lesioned striatum (by 77 % and 66%, respectively) and moderately (27%) but significantly increased the de novo formation of KYNA[1].
Administered to pregnant rats or mice on the last day of gestation, UPF 648 (50 mg/kg, i.p.) produced qualitatively similar changes (i.e., large increases in kynurenine and KYNA and reductions in 3-HK and QUIN) in the brain and liver of the offspring. Rat pups delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia showed further enhanced brain KYNA levels[2].
UPF 648, has an IC50 of 20 nM and provides protection against intrastriatal QUIN injections in kynurenine aminotransferase (KAT II) deficient mice. UPF 648 treatment also shifts KP metabolism towards enhanced neuroprotective KYNA formation[3].
storage
Store at +4°C
UPF 648 Preparation Products And Raw materials
Raw materials
Preparation Products
UPF 648 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44910 | 58 |
