5-Chlorothiophene-2-sulfonyl chloride
- CAS No.
- 2766-74-7
- Chemical Name:
- 5-Chlorothiophene-2-sulfonyl chloride
- Synonyms
- AKOS B019398;BUTTPARK 27\04-09;TIMTEC-BB SBB003378;ART-CHEM-BB B019398;5-chlorothiophene-2-sulfonyl;5-chlorobenzenesulfonyl chloride;5-CHLORO-2-THIENYLSULFONYL CHLORIDE;5-CHLOROTHIOPHENESULPHONYL CHLORIDE;5-Chlorothiophen-2-sulfonyl chloride;5-CHLOROTHIOPHENESULFONYLCHLORIDE,96%
- CBNumber:
- CB4283960
- Molecular Formula:
- C4H2Cl2O2S2
- Molecular Weight:
- 217.09
- MDL Number:
- MFCD00051667
- MOL File:
- 2766-74-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Chlorothiophene-2-sulfonyl chloride 96% | 544272 | 5g | $39.2 |
| 5-Chlorothiophene-2-sulfonyl chloride 96% | 544272 | 1g | $25 |
| 5-Chloro-2-thiophenesulfonyl Chloride >98.0%(GC)(T) | C2343 | 5g | $63 |
| 5-Chloro-2-thiophenesulfonyl Chloride >98.0%(GC)(T) | C2343 | 25g | $252 |
| 5-Chloro-2-thiophenesulfonyl chloride Asreported | 267381 | 5g | $307 |
| More product size | |||
| Melting point | 25-28°C |
|---|---|
| Boiling point | 112-117 °C (lit.) |
| Density | 1.623 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| form | solid |
| Specific Gravity | 1.623 |
| color | Colorless to Yellow to Orange |
| Water Solubility | Not miscible in water. |
| Sensitive | Moisture Sensitive |
| BRN | 130710 |
| InChI | InChI=1S/C4H2Cl2O2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H |
| InChIKey | SORSTNOXGOXWAO-UHFFFAOYSA-N |
| SMILES | C1(S(Cl)(=O)=O)SC(Cl)=CC=1 |
| CAS DataBase Reference | 2766-74-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-29-14 | |||||||||
| Safety Statements | 26-27-36/37/39-45-28A-25 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
|||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
5-Chlorothiophene-2-sulfonyl chloride price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 544272 | 5-Chlorothiophene-2-sulfonyl chloride 96% | 2766-74-7 | 5g | $39.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 544272 | 5-Chlorothiophene-2-sulfonyl chloride 96% | 2766-74-7 | 1g | $25 | 2023-06-20 | Buy |
| TCI Chemical | C2343 | 5-Chloro-2-thiophenesulfonyl Chloride >98.0%(GC)(T) | 2766-74-7 | 5g | $63 | 2026-04-30 | Buy |
| TCI Chemical | C2343 | 5-Chloro-2-thiophenesulfonyl Chloride >98.0%(GC)(T) | 2766-74-7 | 25g | $252 | 2026-04-30 | Buy |
| Usbiological | 267381 | 5-Chloro-2-thiophenesulfonyl chloride Asreported | 2766-74-7 | 5g | $307 | 2026-06-03 | Buy |
5-Chlorothiophene-2-sulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid
Uses
5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.
Uses
5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.
Synthesis Reference(s)
Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6
General Description
5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.
Synthesis
96-43-5
2766-74-7
The following procedure is adapted from C. A. Hunt et al. J. Med. Chem. 1994, 37, 240-247. chlorosulfonic acid (240 mL, 3.594 mol) was added to a three-necked round-bottomed flask equipped with a mechanical stirrer, air condenser, dropping funnel, and moisture-proof tubing. Phosphorus pentachloride (PCl5, 300 g, 1.44 mol, 0.40 eq.) was added in batches with stirring, taking 45 minutes. During the addition process, a large amount of hydrogen chloride gas was violently released, but the temperature of the mixture did not rise significantly (<40 °C). When all the PCl5 was added, an almost clear light yellow solution was formed with only a few solid fragments suspended in it. Stirring was continued until gas escape ceased (~0.5 h). Subsequently, the reaction vessel was cooled in an ice bath and 2-chlorothiophene (66.0 mL, 0.715 mol) was slowly added through a dropping funnel over a period of 1.0 hour. After the addition of the first few drops of 2-chlorothiophene, the mixture changed to a dark purple color, and when all the thiophene was added, a dark purple solution was formed. Hydrogen chloride gas was continuously released at a slow rate during the addition. The reaction mixture was stirred at room temperature overnight. Subsequently, the dark purple clear solution was added dropwise to crushed ice (3 L) over a period of 0.5 hours. The purple color disappeared instantly, except for the ice, and a colorless dilute emulsion was formed, which was mechanically stirred at room temperature for about 1 hour. Next, the mixture was extracted with dichloromethane (CH2Cl2, 3 x 300 mL). The combined dichloromethane extracts were washed sequentially with water (1 × 200 mL), saturated sodium bicarbonate solution (NaHCO3, 1 × 250 mL), and brine (1 × 100 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated on a rotary evaporator to give the crude product as a pale white to pale yellow viscous mass, which gradually solidified into a semi-solid. Finally, it was purified by high vacuum distillation (boiling point 110-112 °C, pressure 712 mmHg) to obtain 135.20 g (88% yield) of 5-chlorothiophene-2-sulfonyl chloride as a colorless to light yellow semi-solid.
References
[1] Patent: WO2007/56167, 2007, A2. Location in patent: Page/Page column 33-34
[2] Patent: WO2008/137809, 2008, A2. Location in patent: Page/Page column 61-62
[3] Pharmazie, 1994, vol. 49, # 2-3, p. 115 - 117
[4] Bulletin of the Chemical Society of Japan, 1985, vol. 58, # 3, p. 1063 - 1064
[5] Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 250,279
5-Chlorothiophene-2-sulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20792 | 58 |
View Lastest Price from 5-Chlorothiophene-2-sulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-29 | 5-Chlorothiophene-2-sulfonyl chloride
2766-74-7
|
1kg | 97% | Changzhou waston chemical technology Co.,Ltd | |||
 |
2019-07-06 | 5-Chlorothiophene-2-sulfonyl chloride
2766-74-7
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 5-Chlorothiophene-2-sulfonyl chloride
2766-74-7
- $0.00
- 97%
- Changzhou waston chemical technology Co.,Ltd
-
- 5-Chlorothiophene-2-sulfonyl chloride
2766-74-7
- $2.00
- 99%
- Career Henan Chemical Co
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