3-Hydroxyphenylacetic acid
- CAS No.
- 621-37-4
- Chemical Name:
- 3-Hydroxyphenylacetic acid
- Synonyms
- 2-(3-hydroxyphenyl)acetic acid;M-HYDROXYPHENYLACETIC ACID;NSC 14360;Valine Impurity 72;3-(Carboxymethyl)phenol;Between the hydroxy acid;3-HYDROXYPHENOLACETICACID;3-Hdroxyphenylacetic acid;3-HYDROXYPHENYLACETIC ACID;3-hydroxy-benzeneaceticaci
- CBNumber:
- CB4337694
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00004337
- MOL File:
- 621-37-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Hydroxyphenylacetic acid ≥99% | H49901 | 5g | $90.6 |
| 3-Hydroxyphenylacetic acid ≥99% | H49901 | 25g | $146 |
| 3-Hydroxyphenylacetic Acid >98.0%(HPLC)(T) | H0356 | 5g | $54 |
| 3-Hydroxyphenylacetic Acid >98.0%(HPLC)(T) | H0356 | 25g | $162 |
| 3-Hydroxyphenylacetic Acid ≥98% | 36436 | 5g | $49 |
| More product size | |||
| Melting point | 129-133 °C(lit.) |
|---|---|
| Boiling point | 234.6°C (rough estimate) |
| Density | 1.2143 (rough estimate) |
| refractive index | 1.4945 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 1000g/l |
| form | Crystalline Powder |
| pka | 4.21±0.10(Predicted) |
| color | White to beige-brown |
| PH | 2.5-2.7 (20g/l, H2O) |
| BRN | 2086506 |
| Stability | Store in Freezer |
| InChI | 1S/C8H8O3/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11) |
| InChIKey | FVMDYYGIDFPZAX-UHFFFAOYSA-N |
| SMILES | OC(=O)Cc1cccc(O)c1 |
| CAS DataBase Reference | 621-37-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | K59Z6Z8REF |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29182990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Hydroxyphenylacetic acid price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H49901 | 3-Hydroxyphenylacetic acid ≥99% | 621-37-4 | 5g | $90.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | H49901 | 3-Hydroxyphenylacetic acid ≥99% | 621-37-4 | 25g | $146 | 2026-04-30 | Buy |
| TCI Chemical | H0356 | 3-Hydroxyphenylacetic Acid >98.0%(HPLC)(T) | 621-37-4 | 5g | $54 | 2026-04-30 | Buy |
| TCI Chemical | H0356 | 3-Hydroxyphenylacetic Acid >98.0%(HPLC)(T) | 621-37-4 | 25g | $162 | 2026-04-30 | Buy |
| Cayman Chemical | 36436 | 3-Hydroxyphenylacetic Acid ≥98% | 621-37-4 | 5g | $49 | 2026-04-30 | Buy |
3-Hydroxyphenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
White Powder
Uses
3-Hydroxyphenylacetic Acid (cas# 621-37-4) is a compound useful in organic synthesis.
Definition
ChEBI: A monocarboxylic acid that is phenylacetic acid in which the hydrogen at position 3 on the benzene ring is replaced by a hydroxy group.
Synthesis Reference(s)
The Journal of Organic Chemistry, 21, p. 1149, 1956 DOI: 10.1021/jo01116a023
Synthesis
In l00mL hydrothermal synthesis reactor, add sodium hydroxide (3mmol), water (5mL), stirring to dissolve, add m-iodophenylacetic acid (0.5mmol), cuprous oxide (0.05mmol), white hardwood cortisol (0.05mmol), the reaction at 100 C stirred uniformly for 6 hours, cooled down with dilute hydrochloric acid to adjust the pH to 2, and then extract with ethyl acetate. , the extract was concentrated and column chromatography, obtained m-hydroxyphenylacetic acid, 54.0 mg, yield 71%.
Purification Methods
Crystallise the acid from *C6H6/ligroin or EtOAc/cyclohexane (m 131-132o). [Beilstein 10 H 189, 10 I 82, 10 II 112, 10 III 428, 10 IV 541.]
3-Hydroxyphenylacetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 | 1097@dideu.com | China | 3992 | 58 |
View Lastest Price from 3-Hydroxyphenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | 3-Hydroxyphenylacetic acid
621-37-4
|
$59.00 | 98.21% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-24 | 3-Hydroxyphenylacetic acid
621-37-4
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-05-23 | 3-Hydroxyphenylacetic acid
621-37-4
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- 3-Hydroxyphenylacetic acid
621-37-4
- $59.00
- 98.21%
- TargetMol Chemicals Inc.
-
- 3-Hydroxyphenylacetic acid
621-37-4
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Hydroxyphenylacetic acid
621-37-4
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
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