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ChemicalBook >> CAS DataBase List >>Losartan carboxylic acid

Losartan carboxylic acid

CAS No.
124750-92-1
Chemical Name:
Losartan carboxylic acid
Synonyms
exp3174;Losartan Carboxylic Acid;e-3174;LOSARTAN CARBOXY ACID;EXP 317;l-158641;AKOS 91941;ALSTint-A07;Losartan acid;E-3174, EXP-3174
CBNumber:
CB4399601
Molecular Formula:
C22H21ClN6O2
Molecular Weight:
436.89
MDL Number:
MFCD00871928
MOL File:
124750-92-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:24:25
Product description Number Pack Size Price
Losartan carboxylic acid ≥95% (HPLC) SMB01354 25MG $361
Losartan carboxylic acid ≥95% (HPLC) SMB01354 5MG $75.9
Losartan Carboxylic Acid ≥98% 15957 1mg $41
Losartan Carboxylic Acid ≥98% 15957 5mg $108
Losartan Carboxylic Acid ≥98% 15957 10mg $178
More product size

Losartan carboxylic acid Properties

Melting point 130-132°C
Boiling point 707.8±70.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Dimethylformamide, Dimethyl Sulfoxide, Methanol
form Solid
pka 0.79±0.50(Predicted)
color Light-Yellow
InChIKey ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1
FDA UNII GD76OCH73X
UNSPSC Code 12352106
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Danger
Hazard statements  H317-H360D-H362
Precautionary statements  P202-P260-P263-P280-P302+P352-P308+P313
Safety Statements  24/25
WGK Germany  WGK 3
HS Code  29339900
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Lact.
Repr. 1B
Skin Sens. 1B

Losartan carboxylic acid price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SMB01354 Losartan carboxylic acid ≥95% (HPLC) 124750-92-1 25MG $361 2026-04-30 Buy
Sigma-Aldrich SMB01354 Losartan carboxylic acid ≥95% (HPLC) 124750-92-1 5MG $75.9 2023-01-07 Buy
Cayman Chemical 15957 Losartan Carboxylic Acid ≥98% 124750-92-1 1mg $41 2026-04-30 Buy
Cayman Chemical 15957 Losartan Carboxylic Acid ≥98% 124750-92-1 5mg $108 2026-04-30 Buy
Cayman Chemical 15957 Losartan Carboxylic Acid ≥98% 124750-92-1 10mg $178 2026-04-30 Buy
Product number Packaging Price Buy
SMB01354 25MG $361 Buy
SMB01354 5MG $75.9 Buy
15957 1mg $41 Buy
15957 5mg $108 Buy
15957 10mg $178 Buy

Losartan carboxylic acid Chemical Properties,Uses,Production

Description

Losartan carboxylic acid is a physiologically active metabolite of losartan , produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation in vitro.

Chemical Properties

Light-Yellow Solid

Uses

Losartan carboxylic acid is used as a metabolite of Losartan.

Definition

ChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.

in vitro

e-3174 potently blocked the specific binding of [125i]-aii to vsmc isolated from rat aorta. e-3174 was able to dampen the platelet-derived growth factor-induced increase in cell dna synthesis and protein, which led to the blockade of the aii-induced increase in cell protein [1].

in vivo

rats were administrated e-3174 intravenously at a dose of l.0 mg/kg. after 6 hours, e-3174 markedly attenuated the cardiovascular effects of aii in rats. e-3174 induced a progressive fall in mean arterial pressure and a marked increase in renal flow only [2].

storage

Store at -20°C

References

[1]. li, x. & widdop, r. angiotensin type i receptor antagonists cy-11974 and exp 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats. clinical science, 1996; 91(2): 147-154.
[2]. sachinidis, a., ko, y., weisser, p., zu bricbkwedde, m., dsing, r., & christian, r. et al. exp3174, a metabolite of losartan (mk954, dup753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells. journal of hypertension. 1993; 11(2): 155-162.

Losartan carboxylic acid Preparation Products And Raw materials

Global( 190)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-17392587031 1059@dideu.com China 9996 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9539 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10457 58

View Lastest Price from Losartan carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Losartan Carboxylic Acid pictures 2026-04-22 Losartan Carboxylic Acid
124750-92-1
 $43.00-158.00 98.36% 10g TargetMol Chemicals Inc.
Losartan Carboxylic Acid pictures 2020-05-10 Losartan Carboxylic Acid
124750-92-1
 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID pictures 2020-01-18 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
124750-92-1
 $1.00 1KG 85.0-99.8% 200kgs Career Henan Chemical Co

Losartan carboxylic acid Spectrum

AKOS 91941 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID ’-biphenyl)-4-yl)methyl)- 1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2’-(14-tetrazol-5-yl)(1,1 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid 1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicAcid EXP 317 Losartan Carboxylic Acid Discontinued see product # L470510 l-158641 EXP 3174 (LOSARTAN CARBOXYLIC ACID) 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-carboxylic acid 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic acid 2-Butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- Losartan Carboxylic Acid NEW CATALOGUE NUMBER: see product # L470510 Losartan acid Losartan carboxylic acid, >=98% 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formic acid LOSARTAN,2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID Losartan Impurity 14 1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1 E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1;1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID Losartan Carboxylic Acid USP/EP/BP 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID USP/EP/BP Losartan Carboxylic Acid (Losartan Carboxylate) Losartan Carboxylic acid Impurity Losartan carboxylic acidQ: What is Losartan carboxylic acid Q: What is the CAS Number of Losartan carboxylic acid Q: What is the storage condition of Losartan carboxylic acid Q: What are the applications of Losartan carboxylic acid 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid ALSTint-A07 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid E-3174, EXP-3174 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174 LOSARTAN CARBOXY ACID Losartan Carboxylic Acid Losartan carboxylic acid in methanol 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Aci Losartan Carboxylic Acid, 10 mM in DMSO Alisartan cilexetil impurity I EXP3174 acid metabolite 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Losartan Carboxylic Acid) Losartan Carboxylic Acid (Standard) e-3174 exp3174 124750-92-1 C22H21ClN6O2 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Heterocycles
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