4-Amino-6-chloropyrimidine
- CAS No.
- 5305-59-9
- Chemical Name:
- 4-Amino-6-chloropyrimidine
- Synonyms
- 6-Chloropyrimidin-4-amine;6-CHLORO-PYRIMIDIN-4-YLAMINE;H50551;NSC 42134;4-Amino-6-chL;4-Amino-6-chloropyri;6-Chloro-4-pyrimidinamine;4-AMINO-6-CHLOROPYRIMIDINE;6-Chloropyrimidine-4-amine;6-AMino-4-chloropyriMidine
- CBNumber:
- CB4424750
- Molecular Formula:
- C4H4ClN3
- Molecular Weight:
- 129.55
- MDL Number:
- MFCD00053576
- MOL File:
- 5305-59-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Amino-6-chloropyrimidine 97% | 735272 | 1g | $47.9 |
| 4-Amino-6-chloropyrimidine >98.0%(GC)(T) | A2136 | 1g | $34 |
| 4-Amino-6-chloropyrimidine >98.0%(GC)(T) | A2136 | 5g | $101 |
| 4-Amino-6-chloropyrimidine | A1376-61 | 2g | $389 |
| 4-AMINO-6-CHLOROPYRIMIDINE 97% | 51610 | 25G | $10 |
| More product size | |||
| Melting point | 215-216°C |
|---|---|
| Boiling point | 289.0±20.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO |
| pka | 2.16±0.10(Predicted) |
| form | Solid |
| color | Pale Yellow |
| InChI | InChI=1S/C4H4ClN3/c5-3-1-4(6)8-2-7-3/h1-2H,(H2,6,7,8) |
| InChIKey | DUKKRSPKJMHASP-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=CC(N)=N1 |
| CAS DataBase Reference | 5305-59-9(CAS DataBase Reference) |
| FDA UNII | 99CMM8EZ3Q |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
4-Amino-6-chloropyrimidine price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 735272 | 4-Amino-6-chloropyrimidine 97% | 5305-59-9 | 1g | $47.9 | 2023-06-20 | Buy |
| TCI Chemical | A2136 | 4-Amino-6-chloropyrimidine >98.0%(GC)(T) | 5305-59-9 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | A2136 | 4-Amino-6-chloropyrimidine >98.0%(GC)(T) | 5305-59-9 | 5g | $101 | 2026-04-30 | Buy |
| Usbiological | A1376-61 | 4-Amino-6-chloropyrimidine | 2g | $389 | 2026-06-03 | Buy | |
| AstaTech | 51610 | 4-AMINO-6-CHLOROPYRIMIDINE 97% | 5305-59-9 | 25G | $10 | 2026-04-30 | Buy |
4-Amino-6-chloropyrimidine Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Anticancer Research
4-Amino-6-chloropyrimidine has been shown to inhibit the proliferation of cancer cells in vitro and in vivo, without affecting normal cells. 4-Amino-6-chloropyrimidine also inhibits kinase activity and protein synthesis in cancer cells. This drug has a potent inhibitory effect on cell proliferation.
Synthesis
1193-21-1
5305-59-9
The general procedure for the synthesis of 4-amino-6-chloropyrimidine from 4,6-dichloropyrimidine was as follows: to a suspension of 4,6-dichloropyrimidine (3.0 g, 20 mmol) in isopropanol (40 mL) was slowly added the appropriate amine, with the rate of addition being controlled so as to maintain the internal temperature of the reaction system at no more than 40°C. The reaction mixture was stirred continuously for 1 hour at 25°C. After addition, the reaction mixture was stirred continuously at 25 °C for 1 hour. Upon completion of the reaction, water (30 mL) was added and the resulting suspension was cooled to 0 °C in an ice bath. The precipitated product was collected by filtration and washed sequentially with pre-cooled isopropanol/water solvent mixture (V/V=2:1, 50 mL) and pure water. Finally, the resulting solid product was dried under vacuum to obtain the target compound 4-amino-6-chloropyrimidine.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7066 - 7083
[2] European Journal of Medicinal Chemistry, 2014, vol. 75, p. 11 - 20
[3] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 84
[4] Patent: US2012/15943, 2012, A1. Location in patent: Page/Page column 54
[5] ChemMedChem, 2017, vol. 12, # 16, p. 1390 - 1398
4-Amino-6-chloropyrimidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3957 | 58 |
View Lastest Price from 4-Amino-6-chloropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 4-Amino-6-chloropyrimidine
5305-59-9
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
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2021-07-13 | 4-Amino-6-chloropyrimidine
5305-59-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | 4-Amino-6-chloropyrimidine
5305-59-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-Amino-6-chloropyrimidine
5305-59-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Amino-6-chloropyrimidine
5305-59-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Amino-6-chloropyrimidine
5305-59-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
