IOCETAMIC ACID (200 MG)
- CAS No.
- 16034-77-8
- Chemical Name:
- IOCETAMIC ACID (200 MG)
- Synonyms
- 3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid;mp620;drc1201;cholimil;colebrina;iocetamic;cholebrine;iocetamicacid;IOCETAMIC ACID (200 MG);IOCETAMIC ACID (200 MG) USP/EP/BP
- CBNumber:
- CB4500528
- Molecular Formula:
- C12H13I3N2O3
- Molecular Weight:
- 613.96
- MDL Number:
- MOL File:
- 16034-77-8.mol
| Product description | Number | Pack Size | Price |
| IOCETAMIC ACID 95.00% | CBL0000383 | 5MG | $499.04 |
| Melting point | 224-225° (NL 6515305); mp range 191-212° (Korver); Consists of 2 isomers having mps 232° and 200-201° |
|---|---|
| Boiling point | 658.2±55.0 °C(Predicted) |
| Density | 2.2000 (rough estimate) |
| refractive index | 1.7400 (estimate) |
| pka | 4.0(at 25℃) |
| Water Solubility | 5.286g/L(37 ºC) |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| FDA UNII | FA675Q0E3E |
| ATC code | V08AC07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H332-H335-H312-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 |
| Hazardous Substances Data | 16034-77-8(Hazardous Substances Data) |
| Toxicity | LD50 in rats (g/kg): 7.1 orally; 0.70 i.v. (Janbroers) |
IOCETAMIC ACID (200 MG) Chemical Properties,Uses,Production
Originator
Cholebrine,Nicholas
Uses
Diagnostic aid (radiopaque medium).
Definition
ChEBI: 3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid is an aromatic amide.
Manufacturing Process
A mixture of equimolecular amounts of m-nitraniline (69.0 g), methacrylic
acid (43.0 g), and pyridine (39.5 g) was heated to 125°C for 20 h, and was
then poured into 500 ml water. A semi-crystalline product separated from the
liquid. The supernatant liquid was decanted and 500 ml fresh water was
added. The pH was adjusted to 7-7.5 by means of sodium hydroxide. The
precipitate was filtered with suction and washed with water. When the filtrate
was acidified with acetic acid, a precipitate of N-(3-nitrophenyl)-β-aminoisobutyric acid was formed. When filtered, washed with water and dried, it
weighed 56.0 g and had a melting point of 130°-131°C (recryst. from
alcohol). The yield was 50% based on nitraniline.
0.25 mol (56.0 g) N-(3-nitrophenyl)-β-aminoisobutyric acid, prepared as
described above, 160 ml glacial acetic acid, and 40 ml acetic anhydride were
heated 48 h to 50°C, and the reaction mixture was poured into 600 ml water.
A crystalline precipitate of N-acetyl-N-(3-nitrophenyl)-β-aminoisobutyric acid
formed gradually. When recovered, it weighed 56.0 g (84% yield). Melting
point 146°-148°C.
100.0 g N-acetyl-N-(3-nitrophenyl)-β-amino-isobutyric acid were dissolved in
1 L water and 40 ml 25% aqueous ammonia, and the solution was
hydrogenated in the presence of about 10.0 g Raney nickel at 20°C and about
450 p.s.i. until the pressure drop indicated the complete conversion of the
NO2 groups to NH2. Thus N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid
was obtained.
The solution of N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid was
filtered after standing overnight, mixed with an equal volume of acetic acid,
and there after with a solution of 275.0 g iodine monochloride and 200.0 g
sodium chloride in 1 L water. The mixture was kept at 50°C with stirring for
48 h. Light brown crystals of crude N-acetyl-N-(2,4,6-triiodo-3-aminophenyl)-
β-amino-isobutyric acid precipitated, were filtered off, washed with water, and
dried. They weighed 195.0 g (84.5% yield based on N-acetyl-N 3-nitrophenylp-amino-isobutyric acid).
brand name
Cholebrine (Mallinckrodt).
Therapeutic Function
Diagnostic aid
Hazard
Low toxicity by ingestion.
IOCETAMIC ACID (200 MG) Preparation Products And Raw materials
IOCETAMIC ACID (200 MG) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| Chongqing jooe co., ltd | +86-15223382610 | info@jooe.com | China | 15971 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 17392216152 | 1050@dideu.com | China | 9998 | 58 |
| Changzhou Xianglong Pharmaceutical Technology Co., Ltd., | 18915873328 18915873328 | sales@xianglongpharm.com | China | 11051 | 58 |
| Qingdao Haizhi Weiyuan Biotechnology Co., Ltd. | 18317699790 18317699790 | l202008112023@163.com | China | 7734 | 58 |
