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Met Signaling Antibody Sampler Kit

CAS No.
Chemical Name:
Met Signaling Antibody Sampler Kit
Synonyms
Met Signaling Antibody Sampler Kit
CBNumber:
CB45653977
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Met Signaling Antibody Sampler Kit Chemical Properties,Uses,Production

Description

The Met Signaling Antibody Sampler Kit provides an economical means to investigate Met signaling. The kit contains primary and secondary antibodies to perform two western blots with each antibody.

Background

Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor, is a disulfide-linked heterodimer made of 45 kDa α- and 145 kDa β-subunits. The α-subunit and the amino-terminal region of the β-subunit form the extracellular domain. The remainder of the β-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of Met with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. These fundamental events are important for all of the biological functions involving Met kinase activity. Addition of a phosphate at cytoplasmic Tyr1003 is essential for ubiquitination and Met protein degradation. Phosphorylation of Tyr1234/1235 in the Met kinase domain is critical to kinase activation. Phosphorylation of Tyr1349 in the Met cytoplasmic domain provides a direct binding site for Gab1. Altered Met levels and/or tyrosine kinase activities are found in several types of tumors, including renal, colon and breast cancers. Thus, Met is an attractive cancer therapeutic and diagnostic target.

References

[1] Weidner, K.M. et al. (1993) Mol Immunol 30, 1003-11.
[2] Park, M. et al. (1986) Cell 45, 895-904.
[3] Bardelli, A. et al. (1997) Oncogene 15, 3103-11.
[4] Taher, T.E. et al. (2002) J Immunol 169, 3793-800.
[5] Schaeper, U. et al. (2000) J Cell Biol 149, 1419-32.
[6] Traxler, P. et al. (2001) Med Res Rev 21, 499-512.

Met Signaling Antibody Sampler Kit Preparation Products And Raw materials

Raw materials

Preparation Products

Met Signaling Antibody Sampler Kit Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Gene Biotechnology International Trading (Shanghai) Co., Ltd. Guangzhou Branch 15107906345 CHINA 6247 58
Guangzhou Jinling Biotechnology Co., Ltd. 15017560539 CHINA 6140 58
Met Signaling Antibody Sampler Kit
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