1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
- CAS No.
- 59767-24-7
- Chemical Name:
- 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
- Synonyms
- Clemastine EP Impurity C;Chloramine T EP impurity C;CleMastine FuMarate IMpurity C;Clemastine Fumarate EP Impurity C;1-(p-Chlorophenyl)-1-phenylethanol;(RS)-1-(4-Chlorophenyl)-1-phenyleth;1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL;Clemastine Impurity 3(EP Impurity C);1-(4-chlorophenyl)-1-phenylethan-1-ol;(RS)-1-(4-Chlorophenyl)-1-phenylethanol
- CBNumber:
- CB4587596
- Molecular Formula:
- C14H13ClO
- Molecular Weight:
- 232.71
- MDL Number:
- MFCD09743490
- MOL File:
- 59767-24-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-(4-Chlorophenyl)-1-phenylethanol British Pharmacopoeia (BP) Reference Standard | BP955 | 25MG | $251 |
| 1-(4-Chlorophenyl)-1-phenylethanol | TRC-C380475-25MG | 25mg | $158 |
| 1-(4-Chlorophenyl)-1-phenylethanol | TRC-C380475-250MG | 250mg | $233 |
| 1-(4-Chlorophenyl)-1-phenylethanol | TRC-C380475-1G | 1g | $540 |
| 1-(4-Chlorophenyl)-1-phenylethanol | JCA76724 | 5g | $900 |
| Boiling point | 358℃ |
|---|---|
| Density | 1.189 |
| Flash point | 170℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 13.41±0.29(Predicted) |
| form | Oil |
| color | Colourless to Light Yellow |
| Major Application |
pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C14H13ClO/c1-14(16,11-5-3-2-4-6-11)12-7-9-13(15)10-8-12/h2-10,16H,1H3 |
| InChIKey | MHJLXHJZQCHSIT-UHFFFAOYSA-N |
| SMILES | Clc1ccc(cc1)C(O)(C)c2ccccc2 |
| FDA UNII | 6149LO684B |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P301+P312+P330-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
| REACH Registrations | Active |
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP955 | 1-(4-Chlorophenyl)-1-phenylethanol British Pharmacopoeia (BP) Reference Standard | 59767-24-7 | 25MG | $251 | 2026-04-30 | Buy |
| TRC | TRC-C380475-25MG | 1-(4-Chlorophenyl)-1-phenylethanol | 59767-24-7 | 25mg | $158 | 2026-06-03 | Buy |
| TRC | TRC-C380475-250MG | 1-(4-Chlorophenyl)-1-phenylethanol | 59767-24-7 | 250mg | $233 | 2026-06-03 | Buy |
| TRC | TRC-C380475-1G | 1-(4-Chlorophenyl)-1-phenylethanol | 59767-24-7 | 1g | $540 | 2026-06-03 | Buy |
| Biosynth | JCA76724 | 1-(4-Chlorophenyl)-1-phenylethanol | 59767-24-7 | 5g | $900 | 2026-06-04 | Buy |
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Chemical Properties,Uses,Production
Uses
1-(4-Chlorophenyl)-1-phenylethanol (Clemastine EP Impurity C) is used in the synthetic preparation of rhodium-catalyzed arylation of nitriles, ketones and imines with tetrafluoroborate or arylboronic acids
Synthesis
108-86-1
99-91-2
59767-24-7
1. A solution was prepared by dissolving bromobenzene (20.31 g, 129.35 mmol) in anhydrous tetrahydrofuran (50 mL) under nitrogen protection. 2. The above solution was added slowly and dropwise to a reaction flask containing magnesium shavings (3.88 g, 159.61 mmol), dry tetrahydrofuran (50 mL) and iodine crystals. 3. After heating and refluxing for about 2 hours, the resulting solution of Grignard reagent was cooled to about 0°C. 4. A tetrahydrofuran solution (100 mL) of 1-(4-chlorophenyl)ethanone (10.0 g, 64.69 mmol) was slowly added dropwise to the cooled Grignard reagent solution described above at 0°C. 5. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for about 18 hours. 6. Upon completion of the reaction, the mixture was cooled to about 0°C and the reaction was quenched by slow addition of saturated ammonium chloride solution. 7. The organic phase was collected after standard extraction using ethyl acetate. 8. The crude product was purified by silica gel column chromatography with petroleum ether solution of 5% ethyl acetate as eluent to afford the title compound 1-(4-chlorophenyl)-1-phenylethanol as an oil (3.80 g, 25% yield). 9. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 1.94 (s, 3H), 2.17 (s, 1H, exchangeable with D2O), 7.23-7.42 (m, 9H). IR (membrane) υ 3414, 3061, 2978, 2927, 2859, 1597, 1489, 1449, 1394 cm-1; MS 215, 217 [(s, 1H, exchangeable with D2O)]. MS 215, 217 [(M+1)-H2O, (M+3)-H2O].
References
[1] Patent: US2009/203763, 2009, A1. Location in patent: Page/Page column 35
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1810 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
View Lastest Price from 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
59767-24-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-08-20 | 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
59767-24-7
|
1kg | 99.99% | 20 tons | Chongqing Soarwin Technology Co., Ltd | ||
 |
2023-10-08 | 1-(4-chlorophenyl)-1-phenylethanol
59767-24-7
|
$30.00 | 1L | 99% | 20T | Firsky International Trade (Wuhan) Co., Ltd |
-
- 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
59767-24-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
59767-24-7
- 99.99%
- Chongqing Soarwin Technology Co., Ltd
-
- 1-(4-chlorophenyl)-1-phenylethanol
59767-24-7
- $30.00
- 99%
- Firsky International Trade (Wuhan) Co., Ltd
