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PICH (D4G8) Rabbit mAb

CAS No.
Chemical Name:
PICH (D4G8) Rabbit mAb
Synonyms
PICH (D4G8) Rabbit mAb
CBNumber:
CB46277682
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

PICH (D4G8) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Monkey

Background

PICH is a helicase of the SNF2 family of ATPases and is essential for proper chromosome segregation during mitosis. While PICH was originally proposed to participate in spindle assembly checkpoint signaling, that function was subsequently called into question. When phosphorylated at Thr1063 by CDK1, PICH binds the polo-box domain of the mitotic kinase PLK1 and targets it to chromosome arms, where it appears to facilitate proper chromosome arm cohesion. PICH is also a substrate of PLK1. Localized to the cytoplasm during interphase, PICH begins to accumulate at centromeres and kinetochores in prometaphase. As chromosomes begin to separate at the onset of anaphase, PICH associates with ultrafine threads between sister centromeres thought to be composed of entangled DNA, a natural consequence of DNA replication. PICH is proposed to cooperate with BLM, a RecQ-like helicase implicated in the genetic disorder Bloom’s Syndrome, to displace centromeric histones along these threads, thus enabling them to span large distances without breaking. This provides a temporal window for topoisomerase IIα-mediated disentanglement. Defects in PICH or BLM disrupt proper chromatid segregation and result in the formation of micronuclei.

References

[1] Baumann, C. et al. (2007) Cell 128, 101-14.
[2] Hübner, N.C. et al. (2010) Chromosoma 119, 149-65.
[3] Leng, M. et al. (2008) Cell Cycle 7, 1480-9.
[4] Kurasawa, Y. and Yu-Lee, L.Y. (2010) Mol Biol Cell 21, 1188-99.
[5] Wang, L.H. et al. (2008) Chromosoma 117, 123-35.
[6] Ke, Y. et al. (2011) EMBO J 30, 3309-31.
[7] Nitiss, J.L. (2009) Nat Rev Cancer 9, 327-37.

PICH (D4G8) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

PICH (D4G8) Rabbit mAb Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Gene Biotechnology International Trading (Shanghai) Co., Ltd. Guangzhou Branch 15107906345 CHINA 6247 58
PICH (D4G8) Rabbit mAb
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