1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
- CAS No.
- 75629-57-1
- Chemical Name:
- 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
- Synonyms
- CS-1229;Oncrasin 1;ZERO/008607;ZINC00439476;AKOS B014321;Oncrasin 1 >ASISCHEM N15726;Oncrasin-1 ，S0780;ART-CHEM-BB B014321;CHEMBRDG-BB 5601604
- CBNumber:
- CB4698434
- Molecular Formula:
- C16H12ClNO
- Molecular Weight:
- 269.73
- MDL Number:
- MFCD01051808
- MOL File:
- 75629-57-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Oncrasin-1 | 496265 | 25mg | $128 |
| Oncrasin-1 ≥98% (HPLC) | O0516 | 5mg | $109 |
| Oncrasin 1 >95.0%(HPLC) | O0450 | 10mg | $101 |
| Oncrasin 1 >95.0%(HPLC) | O0450 | 50mg | $351 |
| Oncrasin-1 ≥98% | 25808 | 10mg | $63 |
| Melting point | 115.0 to 119.0 °C |
|---|---|
| Boiling point | 465.5±30.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light tan |
| Sensitive | Light Sensitive |
| InChI | 1S/C16H12ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2 |
| InChIKey | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.9000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 496265 | Oncrasin-1 | 75629-57-1 | 25mg | $128 | 2023-06-20 | Buy |
| Sigma-Aldrich | O0516 | Oncrasin-1 ≥98% (HPLC) | 75629-57-1 | 5mg | $109 | 2022-05-15 | Buy |
| TCI Chemical | O0450 | Oncrasin 1 >95.0%(HPLC) | 75629-57-1 | 10mg | $101 | 2025-07-31 | Buy |
| TCI Chemical | O0450 | Oncrasin 1 >95.0%(HPLC) | 75629-57-1 | 50mg | $351 | 2025-07-31 | Buy |
| Cayman Chemical | 25808 | Oncrasin-1 ≥98% | 75629-57-1 | 10mg | $63 | 2026-04-30 | Buy |
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties,Uses,Production
Uses
Oncrasin 1 is a proapoptotic compound.
Definition
ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.
Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .
storage
+4°C
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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