TN-16
- CAS No.
- 33016-12-5
- Chemical Name:
- TN-16
- Synonyms
- TN-16;Nsc 239274;TN-16, 10 mM in DMSO;3-(ANILINOETHYLIDENE)-5-BENZYLPYRROLIDINE-2,4-DIONE;3-(1-ANILINOETHYLIDENE)-5-BENZYLPYRROLIDINE-2,4-DIONE;TN-16,TN16,TN 16,inhibit,Microtubule/Tubulin,Inhibitor;5-Benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione;2,4-Pyrrolidinedione, 3-(1-anilinoethylidene)-5-benzyl- (8ci);3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione;2,4-Pyrrolidinedione, 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-
- CBNumber:
- CB4774585
- Molecular Formula:
- C19H18N2O2
- Molecular Weight:
- 306.36
- MDL Number:
- MFCD02684017
- MOL File:
- 33016-12-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| TN-16 ≥98% (HPLC) | T7580 | 5mg | $146 |
| TN-16 ≥98% (HPLC) | T7580 | 25mg | $455 |
| TN-16 | T3877 | 25MG | $149 |
| TN-16 | T3877 | 100MG | $410 |
| TN-16 ≥98% | 21222 | 10mg | $49 |
| Melting point | 182～185℃ |
|---|---|
| Boiling point | 532.7±50.0 °C(Predicted) |
| Density | 1.249±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥17mg/mL |
| pka | 10.53±0.40(Predicted) |
| form | powder |
| color | white to tan |
| InChI | 1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13- |
| InChIKey | KWSXUGYAGMSUTN-LGMDPLHJSA-N |
| SMILES | C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H400 |
| Precautionary statements | P273-P280-P302+P352 |
| Hazard Codes | Xi,N |
| Risk Statements | 43-50/53 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Skin Sens. 1 |
TN-16 price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T7580 | TN-16 ≥98% (HPLC) | 33016-12-5 | 5mg | $146 | 2026-04-30 | Buy |
| Sigma-Aldrich | T7580 | TN-16 ≥98% (HPLC) | 33016-12-5 | 25mg | $455 | 2026-04-30 | Buy |
| TCI Chemical | T3877 | TN-16 | 33016-12-5 | 25MG | $149 | 2026-04-30 | Buy |
| TCI Chemical | T3877 | TN-16 | 33016-12-5 | 100MG | $410 | 2026-04-30 | Buy |
| Cayman Chemical | 21222 | TN-16 ≥98% | 33016-12-5 | 10mg | $49 | 2026-04-30 | Buy |
TN-16 Chemical Properties,Uses,Production
Uses
TN-16 is an antitumor drug that blocks microtubule assembly. Tubulin inhibitor.
Biological Activity
3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor th at could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.', 'Inhibitor of microtubule assembly', 'TN-16 is a synthetic compound th at blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.
TN-16 Preparation Products And Raw materials
Raw materials
Preparation Products
TN-16 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3958 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Hebei Conchain Biotech Co.,Ltd | +86-13630830762 +86-13630830762 | 2415217937@qq.com | China | 135 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
