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(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine structure

CAS No.: 167316-27-0

Chemical Name:: (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

Synonyms: (S,S)-TSDPEN;N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide;(1S,2S)-TSDPEN;(1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine;2S)-(+)-N-p-Tosyl-1;2-diphenylethylenediaMine;(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-;(1S,2S)-N-P-TOSYL-1,2-DIPHENYLETHYLENE-D;(1S,2S)-N-Tosyl-1,2-diphenylethylene-1,2-diamine;(1S,2S)-(-)-N-P-TOSYL-1,2-DIPHENYLETHYLENEDIAMINE

CBNumber:: CB4775946

Molecular Formula:: C21H22N2O2S

Molecular Weight:: 366.48

MDL Number:: MFCD03095684

MOL File:: 167316-27-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:26:37

Product description	Number	Pack Size	Price
(1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine 98%	484342	1g	$45.3
(S,S)-N-(2-Amino-1,2-diphenylethyl)-p-toluenesulfonamide >98.0%(T)	A1699	1g	$131
(1S,2S)-(+)-N-(4-toluene-sulfonyl)-1,2-diphenyl-ethylenediamine, 98% (S,S)-TsDPEN 98%	07-2370	500mg	$66
(1S,2S)-(+)-N-(4-toluene-sulfonyl)-1,2-diphenyl-ethylenediamine, 98% (S,S)-TsDPEN 98%	07-2370	2g	$128
(1S,2S)-(+)-N-(4-toluene-sulfonyl)-1,2-diphenyl-ethylenediamine, 98% (S,S)-TsDPEN 98%	07-2370	10g	$440
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(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Properties

Melting point	128-131 °C (lit.)
alpha	61.5 º (C=1, CH2Cl2)
Boiling point	537.3±60.0 °C(Predicted)
Density	1.1440 (rough estimate)
refractive index	30 ° (C=1, CHCl3)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Solubility in hot Acetonitrile (almost transparency).
pka	10.76±0.50(Predicted)
form	crystal
color	white
optical activity	[α]20/D +35°, c = 1 in chloroform
InChI	InChI=1S/C21H22N2O2S/c1-16-12-14-19(15-13-16)26(24,25)23-21(18-10-6-3-7-11-18)20(22)17-8-4-2-5-9-17/h2-15,20-21,23H,22H2,1H3/t20-,21-/m0/s1
InChIKey	UOPFIWYXBIHPIP-SFTDATJTSA-N
SMILES	C1(S(N[C@@H](C2=CC=CC=C2)[C@@H](N)C2=CC=CC=C2)(=O)=O)=CC=C(C)C=C1
CAS DataBase Reference	167316-27-0(CAS DataBase Reference)
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29242990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine price More Price(112)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	484342	(1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine 98%	167316-27-0	1g	$45.3	2026-04-30	Buy
TCI Chemical	A1699	(S,S)-N-(2-Amino-1,2-diphenylethyl)-p-toluenesulfonamide >98.0%(T)	167316-27-0	1g	$131	2026-04-30	Buy
Strem Chemicals	07-2370	(1S,2S)-(+)-N-(4-toluene-sulfonyl)-1,2-diphenyl-ethylenediamine, 98% (S,S)-TsDPEN 98%	167316-27-0	500mg	$66	2026-04-30	Buy
Strem Chemicals	07-2370	(1S,2S)-(+)-N-(4-toluene-sulfonyl)-1,2-diphenyl-ethylenediamine, 98% (S,S)-TsDPEN 98%	167316-27-0	2g	$128	2026-04-30	Buy
Strem Chemicals	07-2370	(1S,2S)-(+)-N-(4-toluene-sulfonyl)-1,2-diphenyl-ethylenediamine, 98% (S,S)-TsDPEN 98%	167316-27-0	10g	$440	2026-04-30	Buy

Product number	Packaging	Price	Buy
484342	1g	$45.3	Buy
A1699	1g	$131	Buy
07-2370	500mg	$66	Buy
07-2370	2g	$128	Buy
07-2370	10g	$440	Buy

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Chemical Properties,Uses,Production

Chemical Properties

White to slightly yellow crystalline powder

Uses

(1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine is used as a catalyst in the synthesis of keramamine C, a carboline alkaloid that is isolated from the Okinawan sponge Amphimedon sp. (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine is also used as a catalyst in the synthesis of Tolvaptan (T536650), a selective oral vasopressin V2-receptor agonist that is used to treat hyponatremia.

Uses

Chiral diamine ligand for cooperative metal-Bronsted acid catalyzed greener reductive amination using hydrogen gas.

Metal-Brnsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

General Description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.

Synthesis

(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine

29841-69-8

98-59-9

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

167316-27-0

Synthesis of Compound 2009: To a 2 L three-necked round-bottomed flask equipped with a temperature probe, magnetic stirring bar, nitrogen inlet, and constant-pressure dropping funnel was added (1S,2S)-1,2-diphenylethylenediamine (20 g, 0.094 mol) and dichloromethane (160 mL). The reaction mixture was cooled to 0-3 °C and 1 M sodium hydroxide solution (160 mL) was added slowly and dropwise while keeping the temperature below 5 °C. Subsequently, a solution of dichloromethane (320 mL) of p-toluenesulfonyl chloride (17.9 g, 0.094 mol) was added dropwise to the reaction system over a period of 2 hours. The biphasic reaction mixture was continued to be stirred at 0-5 °C for 1 h. Completion of the reaction was confirmed by thin layer chromatography (TLC, 50% ethyl acetate/heptane, UV detection). After completion of the reaction, the organic and aqueous phases were separated, and the organic phase was washed sequentially with water (2×320 mL) and saturated saline (320 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the crude product. The crude product was dissolved in toluene (200 mL) at 70-80 °C, maintained at this temperature, and heptane (300 mL) was added in batches. The resulting slurry was cooled to 20-25 °C and stirred for 1 hour, then further cooled to 0-5 °C and stirred for 10 minutes. The solid was collected by filtration and washed with a heptane solution of 50% toluene (3 x 1 bed volume) to give compound 2009 (30.24 g, 88% yield) as a white powder.

References

[1] Organic and Biomolecular Chemistry, 2011, vol. 9, # 7, p. 2505 - 2511
[2] Journal of Organic Chemistry, 2004, vol. 69, # 4, p. 1283 - 1289
[3] Patent: WO2010/120719, 2010, A1. Location in patent: Page/Page column 194; 196-197
[4] Patent: CN106496099, 2017, A. Location in patent: Paragraph 0033; 0034; 0035; 0048; 0049
[5] Organic Syntheses, 2005, vol. 82, p. 10 - 17

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Preparation Products And Raw materials

Raw materials

(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine Tosyl chloride Sodium hydroxide Dichloromethane

Preparation Products

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Suppliers

Global( 284)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14025	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	964	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
Hebei shuoxi biotechnology co. LTD	58

View Lastest Price from (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine 167316-27-0		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-03-17	(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine 167316-27-0	$60.00	10g	99.8%	10tons	Hebei shuoxi biotechnology co. LTD
2020-11-16	(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine 167316-27-0	$15.00	25Kg/Bag	99%	20 Tons	Longyan Tianhua Biological Technology Co., Ltd

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine
167316-27-0
98%
Henan Aochuang Chemical Co.,Ltd.

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine
167316-27-0
$60.00
99.8%
Hebei shuoxi biotechnology co. LTD

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine
167316-27-0
$15.00
99%
Longyan Tianhua Biological Technology Co., Ltd

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Spectrum

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine(167316-27-0)¹HNMR (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine(167316-27-0)IR

167316-27-0((1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine)Related Search:

N,N,N',N'-Tetramethylethylenediamine 2-(2-Aminoethylamino)ethanol Ethylenediamine 1,2-Diphenylethylenediamine Toluenesulfonamide

Toluene (R,R)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine(Chloro)(p-cymene)ruthenium(II) (S,S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine(chloro)(p-cymene)ruthenium(II) (1R,2R)-(-)-N-p-Tosyl-1,2-diphenylethylenediamine (1R,2R)-N,N'-DI-P-TOLUENESULFONYL-1,2-DIPHENYL-1,2-ETHYLENEDIAMINE

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine (1S,2S)-(-)-N,N'-Bis(4-toluenesulfonyl)-1,2-diphenylethylenediamine (1R,2R)-(+)-N,N'-Bis(4-toluenesulfonyl)-1,2-diphenylethylenediamine AURORA KA-7169 CHLORO[(1S,2S)-N-(P-TOLUENESULFONYL)-1,2-DIPHENYL-1,2-ETHANEDIAMINE] (MESITYLENE)RUTHENIUM(II)

CHLORO[(1S,2S)-N-(P-TOLUENESULFONYL)-1,2-DIPHENYL-1,2-ETHANEDIAMINE] (P-CYMENE)RUTHENIUM(II) RU[(S,S)-TSDPEN](P-CYMENE)

1of4

(1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine (S,S)-Ts-DPEN, (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine, 98% (S,S)-N-(P-TOLUENESULFONYL)-1,2-DIPHENYLETHYLENEDIAMINE (1S, 2S)-(+)-N-(4-TOLUENE SULFONYL)1,2-DIPHENYL-1,2-ETHANE DIAMINE (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediaMine, 98% 500MG (1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine≥ 99% (Assay, Chiral purity) (1S,2S)-N-p-Tosyl-1,2-diphenylethylenediamine,99%e.e. (1S,2S)-(-)-N-p-Tosyl-1,2-diphenylethylenediaMine SynonyMs (S,S)-TsDPEN (1S,2S)-N-Tosyl-1,2-diphenylethylene-1,2-diamine (S,S)-N-(2-AMINO-1,2-DIPHENYLETHYL)-P-TOLUENESULFONAMIDE (1S,2S)-N-(4-TOLUENESULFONYL)-1,2-DIPHENYLETHYLENE-1,2-DIAMINE (1S,2S)-(+)-N-(4-TOLUENESULFONYL)-1,2-DIPHENYLETHYLENEDIAMINE (1S,2S)-(+)-N-(4-TOLUENESULPHONYL)-1,2-DIPHENYLETHYLENEDIAMINE (1S,2S)-N-(P-TOLUENESULFONYL)-1,2-DIPHENYL-1,2-ETHANEDIAMINE (1S,2S)-(-)-N-P-TOSYL-1,2-DIPHENYLETHYLENEDIAMINE (1S,2S)-(+)-N-P-TOSYL-1,2-DIPHENYLETHYLENEDIAMINE (1S,2S)-N-P-TOSYL-1,2-DIPHENYLETHYLENE-D (1S,2S)-(+)-N-(4-toluenesulfonyl)-1,2-diphenylethylenediamine,98%(S,S)-TsDPEN (1S,2S)-(+)-N-(4-TOLUENESULFONYL)-1,2-DIPHENYLETHYLENEDIAMINE (S,S)-TSDPEN (1S,2S)-(-)-N-P-TOSYL-1,2-DIPHENYLETHYLENEDIAMINE 98% (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2- 2-diphenylethylenediaMine 2S)-(+)-N-p-Tosyl-1 (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine,98% (1S,2S)-N-p-toluenesulfonyl-1,2-dipheneylethylenediamine (S,S)-N-(2-Amino-1,2-diphenylethyl)-p-toluenesulfonamide > (1S,2S)-(+)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine Benzenesulfonamide, N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methyl- (1S,2S)-(+)-N-(4-toluenesulfonyl)-1,2-diphenylethylenediamine,98%,99%ee (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamin... (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylen (1S,2S)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine / S-DPEN Tos (1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine, 98%min (1S,2S)-(+)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine ((S,S)-TsDPEN) (1S,2S)-TSDPEN (S,S)-TSDPEN N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide 167316-27-0 CH3C6H4SO2NHCHC6H5CHC6H5NH2 C21H23N2O2S Asymmetric Synthesis Chiral Catalysts, Ligands, and Reagents Hydrogenation Chiral Nitrogen DPEN Series API intermediates Asymmetric Synthesis Synthetic Organic Chemistry Asymmetric Synthesis Chiral Catalysts, Ligands, and Reagents HydrogenationChiral Building Blocks Organic Building Blocks Polyamines organic amine

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(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Properties

SAFETY

Risk and Safety Statements

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine price More Price(112)

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

General Description

Synthesis

References

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Preparation Products And Raw materials

Raw materials

Preparation Products

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Suppliers

View Lastest Price from (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine manufacturers

(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine Spectrum

167316-27-0((1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine)Related Search: