(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
![(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Structure](CAS/GIF/627865-18-3.gif)
- CAS No.
- 627865-18-3
- Chemical Name:
- (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
- Synonyms
- CAY10471;CAY10471, CRTH2/DP2 antagonist;2-[3-[(4-fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid);(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
- CBNumber:
- CB4782807
- Molecular Formula:
- C21H21FN2O4S
- Molecular Weight:
- 416.47
- MDL Number:
- MFCD08062186
- MOL File:
- 627865-18-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CAY10471 ≥95% | 10006735 | 1mg | $74 |
| CAY10471 ≥95% | 10006735 | 5mg | $327 |
| CAY10471 ≥95% | 10006735 | 10mg | $578 |
| CAY10471 ≥95% | 10006735 | 50mg | $2522 |
| CAY10471 ≥95% | 10006735 | 1mg | $67 |
(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Properties
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.5 mg/ml; Ethanol: 15 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| FDA UNII | F449K9EB2G |
(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10006735 | CAY10471 ≥95% | 627865-18-3 | 1mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 10006735 | CAY10471 ≥95% | 627865-18-3 | 5mg | $327 | 2026-04-30 | Buy |
| Cayman Chemical | 10006735 | CAY10471 ≥95% | 627865-18-3 | 10mg | $578 | 2026-04-30 | Buy |
| Cayman Chemical | 10006735 | CAY10471 ≥95% | 627865-18-3 | 50mg | $2522 | 2026-04-30 | Buy |
| Cayman Chemical | 10006735 | CAY10471 ≥95% | 627865-18-3 | 1mg | $67 | 2024-03-01 | Buy |
(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Chemical Properties,Uses,Production
Uses
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model[1][2][3].
in vivo
CAY10471 (oral treatment; 2 mg/kg; challenged on day 22 or over 10 consecutive days) shows a diminished inflammation in chronic contact hypersensitivity (CHS) and IgE-CAI model. It blocks CRTH2 partly, but significantly suppresses inflammation in mice[2].CAY10471 (oral adminstration; 20 mg/kg; twice daily; beginning 3/4/5 days before UUO) significantly attenuates interstitial collagen deposition in the cortex when compared with the vehicle (8.40% versus 14.85%). Oral administration from 3 days after UUO also significantly attenuates interstitial collagen deposition in the cortex compared with vehicle (9.63% versus 14.44%). However, oral administration beginning 5 days after UUO has little effect on interstitial collagen deposition in the cortex when compared with vehicle (14.61% versus 15.09%). Unilateral ureteral obstruction (UUO)[3].
| Animal Model: | Balb/c mice, DP/ mice, CRTH2/ mice[2] |
| Dosage: | 2 mg/kg |
| Administration: | Oral treatment; once daily; challenged on day 22 or over 10 consecutive days |
| Result: | Significantly suppressed both CHS and IgE-CAI inflammatory responses. |
| Animal Model: | C57BL/6 mice[3] |
| Dosage: | 20 mg/kg |
| Administration: | Oral treatment; twice daily; beginning 3/4/5 days before UUO |
| Result: | Slowed the progression of renal fibrosis in the obstructed kidneys. |
IC 50
CRTH2
References
[1] Hatanaka M, et al. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2)antagonistCAY10471 in PC12 cells. J Pharmacol Sci.2010;113(1):89-93. Epub 2010 Apr 16. DOI:10.1254/jphs.10001sc
[2] Matsushima Y, et al. Distinct roles of prostaglandin D2 receptors in chronic skin inflammation.Mol Immunol. 2011 Oct;49(1-2):304-10. DOI:10.1016/j.molimm.2011.08.023
[3] Ito H, et al. PGD2-CRTH2pathway promotes tubulointerstitial fibrosis.J Am Soc Nephrol.2012 Nov;23(11):1797-809. DOI:10.1681/ASN.2012020126
(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| amyjet | 4006800868;027-59626688 18371453821;18771149750 | sales@amyjet.com | China | 2917 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 6000 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6838 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
