Thiamethoxam
- CAS No.
- 153719-23-4
- Chemical Name:
- Thiamethoxam
- Synonyms
- Thiametoxam;3-(2-CHLORO-5-THIAZOLYLMETHYL)TETRAHYDRO-5-METHYL-N-NITRO-4H-1,3,5-OXADIAZIN-4-IMINE;Thiomethoxam;Actara;hiamethoxam;Adage;Cruiser;Adage 5fs;Actara 2gr;Ccris 9026
- CBNumber:
- CB5105069
- Molecular Formula:
- C8H10ClN5O3S
- Molecular Weight:
- 291.71
- MDL Number:
- MFCD03792862
- MOL File:
- 153719-23-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Thiamethoxam PESTANAL?, analytical standard | 37924 | 100mg | $98.5 |
| Thiamethoxam | T3811 | 1G | $64 |
| Thiamethoxam | T3811 | 5G | $188 |
| Thiamethoxam | T3811 | 25G | $562 |
| Thiamethoxam ≥98% | 25784 | 50mg | $49 |
| More product size | |||
| Melting point | 139.1° |
|---|---|
| Boiling point | 485.8±55.0 °C(Predicted) |
| Density | 1.71±0.1 g/cm3(Predicted) |
| vapor pressure | 6.6 x 10-9 Pa (25 °C) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: 250 mg/mL (857.02 mM) |
| form | Solid |
| pka | 0.99±0.10(Predicted) |
| Water Solubility | 4.1 x 103 mg l-1 (25 °C) |
| color | Off-white to yellow |
| BRN | 8491021 |
| Henry's Law Constant | 2.1×109 mol/(m3Pa) at 25℃, HSDB (2015) |
| Major Application |
agriculture environmental |
| InChI | InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3 |
| InChIKey | NWWZPOKUUAIXIW-DHZHZOJOSA-N |
| SMILES | O1CN(C)C(=N[N+]([O-])=O)N(CC2SC(Cl)=NC=2)C1 |
| LogP | -0.13 at 25℃ |
| FDA UNII | 747IC8B487 |
| Pesticides Freedom of Information Act (FOIA) | Thiamethoxam |
| EPA Substance Registry System | Thiamethoxam (153719-23-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-50/53 | |||||||||
| Safety Statements | 22-61-60 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29341000 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Flam. Sol. 1 Repr. 2 |
|||||||||
| Hazardous Substances Data | 153719-23-4(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in rats (mg/kg): 1563 orally, >2000 dermally; LD50 in bobwhite quail, mallard duck (mg/kg): 1552, 576 orally. LC50 (96hr) in rainbow trout, bluegill (mg/l): >100, >114 (Senn). | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Thiamethoxam price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 37924 | Thiamethoxam PESTANAL?, analytical standard | 153719-23-4 | 100mg | $98.5 | 2026-04-30 | Buy |
| TCI Chemical | T3811 | Thiamethoxam | 153719-23-4 | 1G | $64 | 2026-04-30 | Buy |
| TCI Chemical | T3811 | Thiamethoxam | 153719-23-4 | 5G | $188 | 2026-04-30 | Buy |
| TCI Chemical | T3811 | Thiamethoxam | 153719-23-4 | 25G | $562 | 2026-04-30 | Buy |
| Cayman Chemical | 25784 | Thiamethoxam ≥98% | 153719-23-4 | 50mg | $49 | 2026-04-30 | Buy |
Thiamethoxam Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Yellow Solid
Uses
Thiamethoxam is a broad spectrum insecticide active against a wide spectrum of sucking and chewing insect pests after foliar, soil or seed treatment.
Definition
ChEBI: Thiamethoxam is an oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively. It has a role as an antifeedant, a carcinogenic agent, an environmental contaminant, a xenobiotic and a neonicotinoid insectide. It is an oxadiazane, a member of 1,3-thiazoles, an organochlorine compound and a 2-nitroguanidine derivative. It derives from a 2-chlorothiazole.
Application
Thiamethoxam is a neonicotinoid insecticide that is used widely in Wisconsin. Thiamethoxam is the active ingredient in a variety of products used in agriculture to kill sucking and chewing insects that feed on roots, leaves, and other plant tissues. Agricultural uses include soil and seed treatments as well as leaf spraying for most row and vegetable crops like corn, soybeans, snap beans, and potatoes. It is also used to control insects in livestock pens, poultry houses, sod farms, golf courses, lawns, household plants, and tree nurseries. It was first registered by the U.S. Environmental Protection Agency in 1999. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens.
Flammability and Explosibility
Flammable
Synthesis
105827-91-6
153719-38-1
153719-23-4
In a 500 ml round bottom flask, 70 g of N,N-dimethylformamide (DMF) as solvent, 150 g of anhydrous potassium carbonate as base, and 80 g of 3-methyl-4-nitroimino-1,3,5-oxadiazine as one of the reactants were added sequentially. The mixture was stirred and warmed to 50°C. 110 g of 2-chloro-5-(chloromethyl)thiazole was added dropwise at a rate of 50 ml/hour in a 250 ml constant pressure dropping funnel, ensuring that the reaction temperature did not exceed 50°C. After the dropwise addition was completed, the reaction was maintained at 50°C for 16 hours. Upon completion of the reaction, the mixture was cooled to 10°C and filtered to obtain the solid product thiamethoxam. Thiamethoxam was analyzed by liquid chromatography with a purity of 98.4% and a yield of 98%.The recovery of N,N-dimethylformamide was 92%.
Metabolic pathway
All the information on thiamethoxam is taken from a summary of the proceedings of meeting published by the manufacturer. Full experimental details are not given in the report and the identity of metabolites is not disclosed (Novartis, 1997).
Degradation
Thiamethoxam is hydrolytically stable at pH 5 (half-life about 200-300 days). The compound is more labile at pH 9 where the half-life is a few days. It is rapidly photodegraded with a half-life of about 1 hour. In aquatic systems, degradation occurs under alkaline conditions and the insecticide is rapidly photodegraded but not readily biodegraded (Novartis, 1997).
Mode of action
Thiamethoxam interferes with nicotinic acetylcholine receptors in the insect’s nervous system, which are essential for proper functioning of the nerves. Within hours of contact or ingestion of thiamethoxam, insects stop feeding. Death usually occurs within 24 to 48 hours.
The activity of thiamethoxam, or any insecticide, at the target site is just one factor in its efficacy. When comparing insecticides, other variables – including how the compound interacts with the environment, the plant and the insect – also contribute to its insecticidal mode of action.
The Insecticide Resistance Action Committee (IRAC) has organized insecticides into 28 groups, plus sub-groups, based on their modes of action. Thiamethoxam is a Group 4A insecticide (neonicotinoids).
References
[1] Patent: CN106188032, 2016, A. Location in patent: Paragraph 0017-0019
[2] Patent: CN103880832, 2016, B. Location in patent: Paragraph 0027-0029
[3] Patent: WO2015/180585, 2015, A1. Location in patent: Page/Page column 13-18
[4] Patent: CN107698578, 2018, A. Location in patent: Paragraph 0028; 0035; 0036; 0040-0042; 0049
[5] Patent: CN108164522, 2018, A. Location in patent: Paragraph 0027; 0030; 0034; 0038
Pesticide Type
Insecticide
Thiamethoxam Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AS WATER CO., LTD. | +86-18994963526 | 1346073549@qq.com | United Kingdom | 176 | 58 |
| Qingdao Trust Agri Chemical Co.,Ltd | +86-008615963231493 +86-008613573296305 | trustagri@hotmail.com | China | 299 | 58 |
| Alchemie Shanghai Co.,Ltd. | +86-15921545397 | cindy_hu@alchemie-shanghai.com | China | 133 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +86-19931165850 | hbjbtech@163.com | China | 1000 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
View Lastest Price from Thiamethoxam manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Thiamethoxam
153719-23-4
|
$31.00-77.00 | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-14 | Thiamethoxam
153719-23-4
|
1kg | 95 | 200000 | Qingdao Trust Agri Chemical Co.,Ltd | ||
 |
2026-05-28 | Thiamethoxam
153719-23-4
|
$10.00 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Thiamethoxam
153719-23-4
- $31.00-77.00
- 99.86%
- TargetMol Chemicals Inc.
-
- Thiamethoxam
153719-23-4
- $0.00
- 95
- Qingdao Trust Agri Chemical Co.,Ltd
-
- Thiamethoxam
153719-23-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
