4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
- CAS No.
- 1194-74-7
- Chemical Name:
- 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
- Synonyms
- 2,5-diMethylpyriMidine-4,6-diol;dimethyl-4,6-dihydroxy-pyrimidine;2,5-dimethyl-4,6-dihydroxy-pyrimidine;-Pyrimidinone,6-hydroxy-2,5-dimethyl-;4, 6-Dihydroxy-2,5-Dimethyl Pyrimidine;6-Hydroxy-2,5-dimethyl-4(3H)-pyrimidinone;6-Hydroxy-2,5-Dimethyl-4(1H)-Pyrimidinone;4-hydroxy-2,5-dimethyl-1H-pyrimidin-6-one;6-hydroxy-2,5-dimethylpyrimidin-4(3H)-one;4(3H)-PyriMidinone, 6-hydroxy-2,5-diMethyl-
- CBNumber:
- CB51081692
- Molecular Formula:
- C6H8N2O2
- Molecular Weight:
- 140.14
- MDL Number:
- MFCD02685061
- MOL File:
- 1194-74-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,5-Dimethyl-4,6-dihydroxypyrimidine | BAA19474 | 10g | $375 |
| 2,5-Dimethyl-4,6-dihydroxypyrimidine 97% | OR918718 | 1g | $48 |
| 2,5-Dimethylpyrimidine-4,6-diol | 152997 | 1.00g | $130 |
| 2,5-Dimethylpyrimidine-4,6-diol | 152997 | 5.00g | $396 |
| 4(1H)-Pyrimidinone,6-hydroxy-2,5-dimethyl- 95+% | CD11334600 | 5g | $238 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BAA19474 | 2,5-Dimethyl-4,6-dihydroxypyrimidine | 1194-74-7 | 10g | $375 | 2026-06-04 | Buy |
| Apolloscientific | OR918718 | 2,5-Dimethyl-4,6-dihydroxypyrimidine 97% | 1194-74-7 | 1g | $48 | 2026-06-04 | Buy |
| Matrix Scientific | 152997 | 2,5-Dimethylpyrimidine-4,6-diol | 1194-74-7 | 1.00g | $130 | 2026-05-18 | Buy |
| Matrix Scientific | 152997 | 2,5-Dimethylpyrimidine-4,6-diol | 1194-74-7 | 5.00g | $396 | 2026-05-18 | Buy |
| Crysdot | CD11334600 | 4(1H)-Pyrimidinone,6-hydroxy-2,5-dimethyl- 95+% | 1194-74-7 | 5g | $238 | 2026-05-27 | Buy |
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) Chemical Properties,Uses,Production
Uses
2,5-Dimethylpyrimidine-4,6-diol is a chemical reagent used in the synthesis of pharmaceutically active dimethylpyrimidines.
Synthesis
609-08-5
1194-74-7
The general procedure for the synthesis of 6-hydroxy-2,5-dimethyl-4(1H)-pyrimidinone from diethyl methylmalonate is as follows: Example 4.1 Synthesis of 2,5-dimethyl-4,6-dihydroxypyrimidine To a single neck flask 40 mL of methanol was added and cooled to 0°C with an ice bath under nitrogen atmosphere. To the reaction mixture was added 9.72 g of sodium methanol (i.e., a solution with a concentration of 3 mol/L), followed by the slow addition of 5 g (53 mmol) of acetamidine hydrochloride at 0 °C. The reaction mixture was stirred at room temperature for about 20 minutes, then 8.3 mL of diethyl methylmalonate was added dropwise. Stirring was continued for 3 hours. After completion of the reaction, the methanol was concentrated under reduced pressure (2 kPa). The crude product was dissolved in a minimal amount of water, cooled to 0 °C, and then acidified with pure acetic acid to pH 4-5. The white precipitate formed was collected by filtration and washed sequentially with water, ether, and pentane. Finally, the white product was dried over P2O5 under reduced pressure (0.2 kPa) to give 3.3 g (49% yield) of the target product. TLC analysis: Rf = 0.2 (silica gel, eluent: dichloromethane-methanol-water-acetic acid, 85:15:2:2). 1H-NMR (DMSO-d6): δ 1.68 (s, 3H, OH-CH2C-CH3); 2.18 (s, 3H, N-C-CH3).
References
[1] Patent: US2006/52398, 2006, A1. Location in patent: Page/Page column 74-75
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3004 | 60 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12351 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 17321281695 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Nanjing River Chemical Co., Ltd. | 13951936332 18305166317 | info@serpharm.com | China | 493 | 55 |
View Lastest Price from 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-02-21 | 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
1194-74-7
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
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- 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
1194-74-7
- $3.00
- 98%
- Career Henan Chemical Co
