Ganoderenic acid D
- CAS No.
- 100665-43-8
- Chemical Name:
- Ganoderenic acid D
- Synonyms
- Ganoderenic acid d;Apoptosis,Inhibitor,inhibit,Ganoderenic acid D;(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid;(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid;(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid;Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-;(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
- CBNumber:
- CB52192797
- Molecular Formula:
- C30H40O7
- Molecular Weight:
- 512.64
- MDL Number:
- MFCD32197329
- MOL File:
- 100665-43-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ganoderenic Acid D ≥98% | 39774 | 1mg | $76 |
| Ganoderenic Acid D ≥98% | 39774 | 5mg | $209 |
| Ganoderenic Acid D ≥98% | 39774 | 10mg | $380 |
| Ganoderenic Acid D ≥98% | 39774 | 25mg | $854 |
| Ganoderenic acid D ≥98% | 300301 | 10mg | $490 |
| More product size | |||
Ganoderenic acid D price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 39774 | Ganoderenic Acid D ≥98% | 100665-43-8 | 1mg | $76 | 2026-04-30 | Buy |
| Cayman Chemical | 39774 | Ganoderenic Acid D ≥98% | 100665-43-8 | 5mg | $209 | 2026-04-30 | Buy |
| Cayman Chemical | 39774 | Ganoderenic Acid D ≥98% | 100665-43-8 | 10mg | $380 | 2026-04-30 | Buy |
| Cayman Chemical | 39774 | Ganoderenic Acid D ≥98% | 100665-43-8 | 25mg | $854 | 2026-04-30 | Buy |
| Usbiological | 300301 | Ganoderenic acid D ≥98% | 100665-43-8 | 10mg | $490 | 2026-06-03 | Buy |
Ganoderenic acid D Chemical Properties,Uses,Production
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the dried fruiting body of Ganoderma lucidum (Leyss. exFr.) Karst. of the Polyporaceae family.
Uses
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.
Definition
ChEBI: Ganoderenic acid D is a triterpenoid.
Biological Activity
Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).
References
[1] TRAN HAI-BANG Kuniyoshi S. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme[J]. Phytochemistry Letters, 2015, 12: Pages 243-247. DOI: 10.1016/j.phytol.2015.04.021
[2] WEIMEI RUAN. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth.[J]. Natural Product Research, 2014, 28 24: 2264-2272. DOI: 10.1080/14786419.2014.938337
[3] YANG JIAO . Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 15: Pages 3556-3561. DOI: 10.1016/j.bmcl.2016.06.023
Ganoderenic acid D Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 | sales@biopurify.com | China | 4616 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 | ada@ipurechemical.com | China | 10236 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
View Lastest Price from Ganoderenic acid D manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-16 | Ganoderenic acid D
100665-43-8
|
$64.00-163.00 | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Ganoderenic acid D
100665-43-8
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2020-01-18 | Ganoderenic acid D
100665-43-8
|
$3.00 | 1KG | 98% | 1kg , 5kg, 50kg | Career Henan Chemical Co |
-
- Ganoderenic acid D
100665-43-8
- $64.00-163.00
- 99.94%
- TargetMol Chemicals Inc.
-
- Ganoderenic acid D
100665-43-8
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Ganoderenic acid D
100665-43-8
- $3.00
- 98%
- Career Henan Chemical Co
