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ChemicalBook >> CAS DataBase List >>Δ4-Dafachronic acid

Δ4-Dafachronic acid

CAS No.
23017-97-2
Chemical Name:
Δ4-Dafachronic acid
Synonyms
3-Oxocholest-4-en-26-oic acid;Δ4-Dafachronic acid;.delta.4-Dafachronic Acid;PSXQJZDFWDKBIP-NNWQCNCGSA-N;Cholest-4-en-26-oic acid, 3-oxo-;Δ4-Dafachronic Acid Exclusive
CBNumber:
CB52415827
Molecular Formula:
C27H42O3
Molecular Weight:
414.62
MDL Number:
MOL File:
23017-97-2.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:27
Product description Number Pack Size Price
Δ4-Dafachronic Acid ≥95% 14100 1mg $121
Δ4-Dafachronic Acid ≥95% 14100 5mg $505
Δ4-Dafachronic Acid ≥95% 14100 10mg $894
Δ4-Dafachronic Acid ≥95% 14100 1mg $110
Δ4-Dafachronic Acid ≥95% 14100 5mg $459

Δ4-Dafachronic acid Properties

Boiling point 554.6±19.0 °C(Predicted)
Density 1.07±0.1 g/cm3(Predicted)
solubility DMF: 5 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.09 mg/ml
form A crystalline solid
pka 4.81±0.21(Predicted)
color White to off-white

Δ4-Dafachronic acid price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14100 Δ4-Dafachronic Acid ≥95% 23017-97-2 1mg $121 2026-04-30 Buy
Cayman Chemical 14100 Δ4-Dafachronic Acid ≥95% 23017-97-2 5mg $505 2026-04-30 Buy
Cayman Chemical 14100 Δ4-Dafachronic Acid ≥95% 23017-97-2 10mg $894 2026-04-30 Buy
Cayman Chemical 14100 Δ4-Dafachronic Acid ≥95% 23017-97-2 1mg $110 2024-03-01 Buy
Cayman Chemical 14100 Δ4-Dafachronic Acid ≥95% 23017-97-2 5mg $459 2024-03-01 Buy
Product number Packaging Price Buy
14100 1mg $121 Buy
14100 5mg $505 Buy
14100 10mg $894 Buy
14100 1mg $110 Buy
14100 5mg $459 Buy

Δ4-Dafachronic acid Chemical Properties,Uses,Production

Description

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12. Δ4-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults. The (25S) diastereomer of Δ4-dafachronic acid is significantly more potent than its (25R) counterpart (EC50s = 23 and 66 nM, respectively).

Uses

Δ4-Dafachronic acid is an agonist of DAF-12 and a metabolite of cholesterol[1].

Definition

ChEBI: Delta(4)-dafachronic acid is a cholestanoid that is cholest-4-en-26-oic acid which is substituted at position 3 by an oxo group. It is a 3-oxo-Delta(4) steroid, a member of dafachronic acids and a C27-steroid. It is a conjugate acid of a Delta(4)-dafachronate.

References

[1] Amie L T Romney, et al. Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12763-12768. DOI:10.1073/pnas.1804590115

Δ4-Dafachronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Δ4-Dafachronic acid Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11972 58
Cayman Chemical Company -- sales@caymanchem.com China 6838 58
ApexBio Technology -- sales@apexbt.com United States 6251 58
Guangzhou Junuo Biotechnology Co., Ltd. -- CHINA 6832 58
Guangzhou Squirrel Biotechnology Co., Ltd. -- CHINA 6609 58
Δ4-Dafachronic acid Δ4-Dafachronic Acid Exclusive PSXQJZDFWDKBIP-NNWQCNCGSA-N .delta.4-Dafachronic Acid Cholest-4-en-26-oic acid, 3-oxo- 3-Oxocholest-4-en-26-oic acid 23017-97-2
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