7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine
![7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine Structure](CAS/GIF/252723-16-3.gif)
- CAS No.
- 252723-16-3
- Chemical Name:
- 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine
- Synonyms
- 4-Chloro-6-methyl-7-(phenylsulfonyl)pyrrolo[2,3-d]pyrimidine;4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine;7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6-methyl-7-(phenylsulfonyl)-
- CBNumber:
- CB52471236
- Molecular Formula:
- C13H10ClN3O2S
- Molecular Weight:
- 307.76
- MDL Number:
- MFCD12407798
- MOL File:
- 252723-16-3.mol
| Product description | Number | Pack Size | Price |
| 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine | 073199 | 250.00mg | $629 |
| 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine | 073199 | 1.00g | $1357 |
| 4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 95% | AD263668 | 250MG | $170 |
| 4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 95% | AD263668 | 1G | $440 |
| 4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 95% | AD263668 | 5G | $1770 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 073199 | 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine | 252723-16-3 | 250.00mg | $629 | 2026-05-18 | Buy |
| Matrix Scientific | 073199 | 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine | 252723-16-3 | 1.00g | $1357 | 2026-05-18 | Buy |
| ACHEMBLOCK | AD263668 | 4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 95% | 252723-16-3 | 250MG | $170 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD263668 | 4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 95% | 252723-16-3 | 1G | $440 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD263668 | 4-Chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 95% | 252723-16-3 | 5G | $1770 | 2026-05-27 | Buy |
7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine Chemical Properties,Uses,Production
Synthesis
![4-CHLORO-7-(PHENYLSULFONYL)-7H-PYRROLO[2,3-D]PYRIMIDINE](/CAS/GIF/186519-89-1.gif)
186519-89-1
74-88-4
![7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine](/CAS/GIF/252723-16-3.gif)
252723-16-3
Step 2: 4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (3 g, 12.6 mmol, 1.0 eq.) and N,N,N',N'-tetramethylethylenediamine (TMEDA) (3.0 mL, 18.9 mmol, 1.5 eq.) were dissolved in tetrahydrofuran (THF) (120 mL), and cooled to -78 °C. The reaction was purified by adding n-butyl lithium (n-BuLi) (7.5 mL, 18.9 mmol, 1.5 eq.). Under stirring, n-butyllithium (n-BuLi) (7.5 mL, 18.9 mmol, 1.5 eq.) was slowly added. after 3 min, iodomethane (C3/4I) (3.7 mL, 59.2 mmol, 4.7 eq.) was added. The reaction mixture was kept stirred at -78 °C for 3 h, followed by a slow warming to room temperature over 1 h. The reaction was completed by the addition of iodomethane (C3/4I). Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution (10 mL). Extraction was performed by adding ethyl acetate (EtOAc) (200 mL) and water (100 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 7-benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine as a brown solid (6.7 g, 90% yield).
References
[1] Patent: WO2012/158795, 2012, A1. Location in patent: Page/Page column 101-102
[2] Patent: WO2012/158764, 2012, A1. Location in patent: Page/Page column 115
[3] Patent: WO2013/191965, 2013, A1. Location in patent: Page/Page column 191
[4] Patent: WO2014/22569, 2014, A1. Location in patent: Page/Page column 96
[5] Patent: US8673925, 2014, B1. Location in patent: Page/Page column 241
7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine Preparation Products And Raw materials
Raw materials
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Preparation Products
7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyri midine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
