ChemicalBook >> CAS DataBase List >>4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
![4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Structure](CAS/GIF/761440-16-8.gif)
- CAS No.
- 761440-16-8
- Chemical Name:
- 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
- Synonyms
- 2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine;2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine;OROPYRIMIDIN-4-YL;Ceritinib Dichloro Impurity;-[(1-methylethyl)sulfonyl]phenyl;2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl);2,5-dichloro-N-(2-propan-2-ylsulfonylphenyl)pyrimidin-4-amine;2,5-dichloro-N-[2-(propane-2-sulfonyl)phenyl]pyrimidin-4-amine;2,5-dichloro-N-[2-(propane-1-sulfonyl)phenyl]pyriMidin-4-aMine;4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]p
- CBNumber:
- CB52473821
- Molecular Formula:
- C13H13Cl2N3O2S
- Molecular Weight:
- 346.23
- MDL Number:
- MFCD12827956
- MOL File:
- 761440-16-8.mol
- TDS File:
- TDS
Last updated:2026-07-31 08:25:00
| Product description | Number | Pack Size | Price |
| 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine >97.0%(HPLC)(N) | D5068 | 200mg | $58 |
| 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine >97.0%(HPLC)(N) | D5068 | 1g | $173 |
| 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine ≥97%(HPLC) | 44864 | 250MG | $151.13 |
| 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine ≥97%(HPLC) | 44864 | 1G | $362.74 |
| 2,5-Dichloro-N-(2-(isopropylsulfonyl)-phenyl)pyrimidin-4-amine | 096607 | 250.00mg | $439 |
| More product size | |||
| Melting point | 149.0 to 153.0 °C |
|---|---|
| Boiling point | 538℃ |
| Density | 1.436 |
| Flash point | 279℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | -0.03±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C13H13Cl2N3O2S/c1-8(2)21(19,20)11-6-4-3-5-10(11)17-12-9(14)7-16-13(15)18-12/h3-8H,1-2H3,(H,16,17,18) |
| InChIKey | WWVLDJAVSQZSKO-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2S(C(C)C)(=O)=O)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2933.59.8000 |
| REACH Registrations | Active |
4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5068 | 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine >97.0%(HPLC)(N) | 761440-16-8 | 200mg | $58 | 2026-04-30 | Buy |
| TCI Chemical | D5068 | 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine >97.0%(HPLC)(N) | 761440-16-8 | 1g | $173 | 2026-04-30 | Buy |
| Chem-Impex | 44864 | 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine ≥97%(HPLC) | 761440-16-8 | 250MG | $151.13 | 2026-05-19 | Buy |
| Chem-Impex | 44864 | 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine ≥97%(HPLC) | 761440-16-8 | 1G | $362.74 | 2026-05-19 | Buy |
| Matrix Scientific | 096607 | 2,5-Dichloro-N-(2-(isopropylsulfonyl)-phenyl)pyrimidin-4-amine | 761440-16-8 | 250.00mg | $439 | 2026-05-18 | Buy |
4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Chemical Properties,Uses,Production
Uses
2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine is used as a reagent in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment.
Synthesis
76697-50-2
5750-76-5
![4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-](/CAS/GIF/761440-16-8.gif)
761440-16-8
To a flask containing 40 g (0.200 mol) 2-(isopropylsulfonyl)aniline (Formula-XI) in 400 mL of toluene solution under nitrogen protection were added 49.7 g (0.27 mol) 2,4,5-trichloropyrimidine (Formula-XII), 81.7 g (0.25 mol) cesium carbonate, 4.5 g (0.02 mol) palladium(II) acetate, and 13.1 g (0.05 mol) triphenylphosphine. The reaction mixture was heated to reflux under nitrogen atmosphere and maintained for 4 hours. The reaction was monitored by thin layer chromatography (TLC) to confirm that 2-(isopropylsulfonyl)aniline was completely consumed. Upon completion of the reaction, the mixture was cooled to 25-30 °C and filtered. The solids were washed with 400 mL of ethyl acetate. The filtrate and washings were combined and the crude product was obtained by removing toluene and ethyl acetate by distillation under reduced pressure at 60 °C. The crude product was purified by column chromatography to afford 45.6 g of 2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine (formula-XIII) as a light yellow solid in 65.6% (theoretical) yield.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 136, p. 497 - 510
[2] Patent: WO2017/158619, 2017, A1. Location in patent: Page/Page column 19
[3] Patent: EP2990405, 2016, A1. Location in patent: Paragraph 0097; 0120; 0121
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 14, p. 5675 - 5690
[5] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 80 - 89
Synthesis of 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- from 1-Fluoro-2-nitrobenzene
4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 246)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 | info@rochipharma.com | China | 505 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shandonghaohong biotechnology Co.,ltd. | 0635-6175299 13961496334 | sale@inyelchem.com | CHINA | 44 | 55 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
View Lastest Price from 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- pictures](/ProductImageEN3/2026-07/Small/a54a5eef-7a93-4713-ab8c-3e424083f0fc.jpg) |
2026-07-31 | 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
761440-16-8
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
![2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine pictures](/ProductImageEN/2022-09/Small/bab881e5-d4a5-4f8e-a56f-f84d093e6340.png) |
2025-04-04 | 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2024-11-26 | 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine
761440-16-8
|
99%(HPLC) | 2000kg/Year | Nanjing Fred Technology Co., Ltd |
-
- 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
761440-16-8
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine
761440-16-8
- 99%(HPLC)
- Nanjing Fred Technology Co., Ltd
761440-16-8(4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-)Related Search:
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2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
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4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
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4-PyriMidinaMine, 2,5-dichloro-N-[2-[(1-Methylethyl)sulfonyl]phenyl]-
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2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine (2,5-Dichloropyrimidin-4-yl)[2-[(propan-2-yl)sulfonyl]phenyl]amine
4-Pyrimidimine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
2,5-dichloro-N-[2-(propane-2-sulfonyl)phenyl]pyrimidin-4-amine
5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
2,5-dichloro-N-(2-propan-2-ylsulfonylphenyl)pyrimidin-4-amine
4-Pyrimidinamine,2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
2,5-Dichloro-N-(2-(Isopropylsulfonyl)Phenyl)Pyrimidin-4-Amine,>98%
OROPYRIMIDIN-4-YL
Ceritinib Dichloro Impurity
-[(1-methylethyl)sulfonyl]phenyl
2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amin...
TIANFU-CHEM - 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
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4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]p
2,5-Dichloro-N-[2-[(1-methyl)sulfonyl]phenyl]-4-pyrimidinamine
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2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine
761440-16-8
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761440-16-8
