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2,4,7-Trichloropyrido[2,3-d]pyrimidine

2,4,7-Trichloropyrido[2,3-d]pyrimidine structure

CAS No.: 938443-20-0

Chemical Name:: 2,4,7-Trichloropyrido[2,3-d]pyrimidine

Synonyms: 100232;2,4,7-Trichloropyrido[2,3...;2,4,7-Trichloropyrido[2,3-d]pyrimidine;Pyrido[2,3-d]pyriMidine, 2,4,7-trichloro-;2,4,7-Trichloropyrido[2,3-d]pyrimidine ISO 9001：2015 REACH

CBNumber:: CB52474792

Molecular Formula:: C7H2Cl3N3

Molecular Weight:: 234.47

MDL Number:: MFCD11109463

MOL File:: 938443-20-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:55:33

Product description	Number	Pack Size	Price
2,4,7-Trichloropyrido[2,3-d]pyrimidine Aldrich	SYX00244	1g	$1490
2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	OR471510	100mg	$21
2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	OR471510	250mg	$44
2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	OR471510	1g	$124
2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	OR471510	5g	$613
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2,4,7-Trichloropyrido[2,3-d]pyrimidine Properties

Boiling point	316.4±42.0 °C(Predicted)
Density	1.685±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-2.53±0.30(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C7H2Cl3N3/c8-4-2-1-3-5(9)12-7(10)13-6(3)11-4/h1-2H
InChIKey	DNFDLCRLLQVUQK-UHFFFAOYSA-N
SMILES	C1(Cl)=NC(Cl)=C2C=CC(Cl)=NC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H301-H318
Precautionary statements	P264-P270-P280-P301+P310-P305+P351+P338-P405
Hazard Codes	T
Risk Statements	25-41
Safety Statements	26-39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
HS Code	2933998090

2,4,7-Trichloropyrido[2,3-d]pyrimidine price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00244	2,4,7-Trichloropyrido[2,3-d]pyrimidine Aldrich	938443-20-0	1g	$1490	2023-01-07	Buy
Apolloscientific	OR471510	2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	938443-20-0	100mg	$21	2026-06-04	Buy
Apolloscientific	OR471510	2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	938443-20-0	250mg	$44	2026-06-04	Buy
Apolloscientific	OR471510	2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	938443-20-0	1g	$124	2026-06-04	Buy
Apolloscientific	OR471510	2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%	938443-20-0	5g	$613	2026-06-04	Buy

Product number	Packaging	Price	Buy
SYX00244	1g	$1490	Buy
OR471510	100mg	$21	Buy
OR471510	250mg	$44	Buy
OR471510	1g	$124	Buy
OR471510	5g	$613	Buy

2,4,7-Trichloropyrido[2,3-d]pyrimidine Chemical Properties,Uses,Production

Uses

2,4,7-Trichloropyrido[2,3-d]pyrimidine is used in the synthetic preparation of dual mTORC1/mTORC2 inhibitors and the discovery of AZD8055 and AZD2014 as potential antitumor agents.

Synthesis

7-Chloropyrido[2,3-d]pyrimidine-2,4-diol

938443-19-7

938443-20-0

The general procedure for the synthesis of 2,4,7-trichloropyrido[2,3-d]pyrimidine (Inter.5) using 7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (Inter.4) as a starting material is as follows: To a stirred anhydrous toluene suspension of 0.5 M Inter.4 (1 equiv.) in an inert atmosphere was slowly added diisopropylethylamine (3 equivalent). The reaction mixture was heated to 70 °C and maintained for 30 min and subsequently cooled to room temperature. Next, phosphorous oxychloride (POCl3, 3 eq.) was added and the reaction mixture was heated to 100 °C for 2.5 hours. Upon completion of the reaction, the mixture was cooled and concentrated under vacuum to give a crude product slurry. The crude product was suspended in ethyl acetate (EtOAc) and filtered through a thin diatomaceous earth pad. The filtrate was concentrated under vacuum to give a brown oil. The oily substance was dissolved in dichloromethane (CH2Cl2) and stirred on silica gel for 30 minutes. Afterwards, the silica gel was removed by filtration and the filtrate was concentrated. The crude product was purified by fast chromatography (silica gel, SiO2) to afford analytically pure 2,4,7-trichloropyrido[2,3-d]pyrimidine (48% yield, 96% purity). Mass spectrometry (LC-MS, ESP) analysis resulted in: m/z 234 [M + H]+, retention time (R/T) = 4.21 min.

References

[1] Patent: WO2007/60404, 2007, A1. Location in patent: Page/Page column 57; 59
[2] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 101
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1212 - 1216
[4] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 102-103
[5] Patent: CN102887895, 2016, B. Location in patent: Paragraph 0310; 0313; 0314

2,4,7-Trichloropyrido[2,3-d]pyrimidine synthesis

Synthesis of 2,4,7-Trichloropyrido[2,3-d]pyrimidine from 7-Chloropyrido[2,3-d]pyrimidine-2,4-diol

2,4,7-Trichloropyrido[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Pyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione 2,6-Dichloronicotinic acid 7-Chloropyrido[2,3-d]pyrimidine-2,4-diol 2-Amino-6-chloronicotinamide 2-Amino-5-chloropyridine-3-carboxylic acid

trichlorophosphate N,N-Diisopropylethylamine

1of2

Preparation Products

4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine DADEPYLIPQQG PACRITINIB (JAK inhibitor)

2,4,7-Trichloropyrido[2,3-d]pyrimidine Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3957	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Shanghai Yudiao Chemistry Technology Co.,Ltd	02137285211 18964703211	info@yudiaochem.com	CHINA	238	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Shanghai Yudiao Chemistry Technology Co.,Ltd	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from 2,4,7-Trichloropyrido[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	2,4,7-Trichloropyrido[2,3-d]pyrimidine 938443-20-0		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-12-29	2,4,7-trichloropyrido[2,3-d]pyrimidine 938443-20-0	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	2,4,7-Trichloropyrido[2,3-d]pyrimidine 938443-20-0	$1.00	1KG	99%		Career Henan Chemical Co

2,4,7-Trichloropyrido[2,3-d]pyrimidine
938443-20-0
98%
Henan Aochuang Chemical Co.,Ltd.

2,4,7-trichloropyrido[2,3-d]pyrimidine
938443-20-0
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

2,4,7-Trichloropyrido[2,3-d]pyrimidine
938443-20-0
$1.00
99%
Career Henan Chemical Co

2,4,7-Trichloropyrido[2,3-d]pyrimidine Spectrum

2,4,7-Trichloropyrido[2,3-d]pyrimidine(938443-20-0)¹HNMR

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