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1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- structure

CAS No.: 633328-98-0

Chemical Name:: 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-

Synonyms: 5-CHLORO-1H-PYRAZOLO[4,3-D]PYRIMIDINE;5-Chloropyrazolo[4,3-d]pyrimidine;1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-

CBNumber:: CB52607295

Molecular Formula:: C5H3ClN4

Molecular Weight:: 154.56

MDL Number:: MFCD18251003

MOL File:: 633328-98-0.mol

MSDS File:: SDS

Last updated:2026-05-28 03:34:56

Product description	Number	Pack Size	Price
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine ≥95%	OR305533	100mg	$21
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine ≥95%	OR305533	250mg	$26
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine 98%	AS140741	1g	$141
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine 98%	AS140741	5g	$495
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine	219401	1.00g	$80
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1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Properties

Density	1.653±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	6.68±0.50(Predicted)
form	solid
color	Yellow
InChI	InChI=1S/C5H3ClN4/c6-5-7-1-4-3(9-5)2-8-10-4/h1-2H,(H,8,10)
InChIKey	MRTKTXTWOUDUTL-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C2NN=CC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P260-P280-P312
HS Code	2933599590

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR305533	5-Chloro-1H-pyrazolo[4,3-d]pyrimidine ≥95%	633328-98-0	100mg	$21	2026-06-04	Buy
Apolloscientific	OR305533	5-Chloro-1H-pyrazolo[4,3-d]pyrimidine ≥95%	633328-98-0	250mg	$26	2026-06-04	Buy
Activate Scientific	AS140741	5-Chloro-1H-pyrazolo[4,3-d]pyrimidine 98%	633328-98-0	1g	$141	2026-06-04	Buy
Activate Scientific	AS140741	5-Chloro-1H-pyrazolo[4,3-d]pyrimidine 98%	633328-98-0	5g	$495	2026-06-04	Buy
Matrix Scientific	219401	5-Chloro-1H-pyrazolo[4,3-d]pyrimidine	633328-98-0	1.00g	$80	2026-05-18	Buy

Product number	Packaging	Price	Buy
OR305533	100mg	$21	Buy
OR305533	250mg	$26	Buy
AS140741	1g	$141	Buy
AS140741	5g	$495	Buy
219401	1.00g	$80	Buy

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Chemical Properties,Uses,Production

Uses

5-Chloro-1H-pyrazolo[4,3-D]pyrimidine is used in preparation of pyrimidine derivatives and related heterocycles as DNA-dependent protein kinase inhibitors for treatment of diseases.

Synthesis

Ethanone, 1-(5-chloro-1H-pyrazolo[4,3-d]pyriMidin-1-yl)-

633328-97-9

633328-98-0

General procedure for the synthesis of 5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl from 1-(5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)ethanone: To a stirred solution of 1-(5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)ethanone (1.5 g, 7.65 mmol) in tetrahydrofuran (THF, 15 mL), was added an 8% hydrochloric acid aqueous solution (14.46 mL). The reaction mixture was refluxed at 50 °C for 30 min. After completion of the reaction, it was cooled to 25 °C and extracted with ethyl acetate (EtOAc, 2 × 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford 5-chloro-1H-pyrazolo[4,3-d]pyrimidine as an off-white solid (1.1 g, 93% yield). Mass spectrum (ESI): m/z = 153.0 [M-H]-.

References

[1] Patent: WO2017/137334, 2017, A1. Location in patent: Page/Page column 123; 124
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0035
[3] Patent: US2012/202785, 2012, A1. Location in patent: Page/Page column 263

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- synthesis

Synthesis of 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- from Ethanone, 1-(5-chloro-1H-pyrazolo[4,3-d]pyriMidin-1-yl)-

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Preparation Products And Raw materials

Raw materials

2,4-Dichloro-6-methyl-5-nitropyrimidine 5-Nitro-6-methyluracil Acetamide, N-(2-chloro-4-methyl-5-pyrimidinyl)- Ethanone, 1-(5-chloro-1H-pyrazolo[4,3-d]pyriMidin-1-yl)- 2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE

5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) 6-Methyluracil Tetrahydrofuran Hydrochloric acid Water

1of2

Preparation Products

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Milon Pharmatech Co.,Ltd.	+86-18083715844	sales02@milonpharm.com	China	334	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	938	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30224	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
Wuxi Rejoys chemical Technology Co., Ltd.	0510-86103381	sales@rejoyschem.com	CHINA	976	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24597	58

Supplier	Advantage
Hangzhou Milon Pharmatech Co.,Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Jinan Liheng Biotechnology Co., Ltd.	58
Career Henan Chemica Co	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
Wuxi Rejoys chemical Technology Co., Ltd.	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Baoji Guokang Healthchem co.,ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Spectrum

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-(633328-98-0)¹HNMR

633328-98-0(1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-)Related Search:

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