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ChemicalBook >> CAS DataBase List >>2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE

CAS No.
1192479-35-8
Chemical Name:
2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE
Synonyms
2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE;Pyrimidine, 2-chloro-5-fluoro-4-methoxy-6-methyl-
CBNumber:
CB52617344
Molecular Formula:
C6H6ClFN2O
Molecular Weight:
176.58
MDL Number:
MFCD16621230
MOL File:
1192479-35-8.mol
Last updated:2026-05-28 03:41:43
Product description Number Pack Size Price
2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine SXB47935 5g $354
2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine 97% PC907736 100mg $44
2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine 97% PC907736 250mg $102
2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine >98% C61752 100mg $29
2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine >98% C61752 250mg $40
More product size

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Properties

Boiling point 278.4±35.0 °C(Predicted)
Density 1.334±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.33±0.39(Predicted)
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933599590

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth SXB47935 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine 1192479-35-8 5g $354 2026-06-05 Buy
Apolloscientific PC907736 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine 97% 1192479-35-8 100mg $44 2026-06-04 Buy
Apolloscientific PC907736 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine 97% 1192479-35-8 250mg $102 2026-06-04 Buy
Synthonix C61752 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine >98% 1192479-35-8 100mg $29 2026-05-06 Buy
Synthonix C61752 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine >98% 1192479-35-8 250mg $40 2026-05-06 Buy
Product number Packaging Price Buy
SXB47935 5g $354 Buy
PC907736 100mg $44 Buy
PC907736 250mg $102 Buy
C61752 100mg $29 Buy
C61752 250mg $40 Buy

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Chemical Properties,Uses,Production

Synthesis

2,4-Dichloro-5-fluoro-6-methylpyrimidine

954220-98-5

Sodium Methoxide

124-41-4

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE

1192479-35-8

To a solution of tetrahydrofuran (THF, 6 mL) containing 2,4-dichloro-5-fluoro-6-methylpyrimidine (563 mg, 3.11 mmol), a methanolic solution of 25% sodium methanolate (671 mg) was slowly added under cooling at 0°C. The reaction mixture was slowly warmed up to room temperature over 1 hour. After completion of the reaction, the reaction solution was diluted with water and extracted with ethyl acetate (EtOAc). The organic phases were combined, concentrated and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford 2-chloro-5-fluoro-4-methoxy-6-methylpyrimidine in quantitative yield.

References

[1] Patent: WO2009/131974, 2009, A1. Location in patent: Page/Page column 88
[2] Patent: WO2014/66132, 2014, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2012/138590, 2012, A1. Location in patent: Page/Page column 71-72
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3231 - 3248

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Preparation Products And Raw materials

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2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Spectrum

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Pyrimidine, 2-chloro-5-fluoro-4-methoxy-6-methyl- 1192479-35-8
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