BroMosporine
- CAS No.
- 1619994-69-2
- Chemical Name:
- BroMosporine
- Synonyms
- CS-921;BroMosporine;BroMosporine USP/EP/BP;Bromosporine, 10 mM in DMSO;KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4;N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate;ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
- CBNumber:
- CB52676961
- Molecular Formula:
- C17H20N6O4S
- Molecular Weight:
- 404.44
- MDL Number:
- MFCD26142669
- MOL File:
- 1619994-69-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Bromosporine ≥98% (HPLC) | SML0992 | 5 mg | $191 |
| Bromosporine ≥98% | 14119 | 1mg | $41 |
| Bromosporine ≥98% | 14119 | 5mg | $119 |
| Bromosporine ≥98% | 14119 | 10mg | $215 |
| Bromosporine ≥98% | 14119 | 25mg | $389 |
| More product size | |||
| Density | 1.46±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) |
| form | solid |
| pka | 6.21±0.46(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | 1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24) |
| InChIKey | UYBRROMMFMPJAN-UHFFFAOYSA-N |
| SMILES | CC(C(NS(C)(=O)=O)=C1)=CC=C1C2=NN3C(C(NC(OCC)=O)=C2)=NN=C3C |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
BroMosporine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0992 | Bromosporine ≥98% (HPLC) | 1619994-69-2 | 5 mg | $191 | 2026-04-30 | Buy |
| Cayman Chemical | 14119 | Bromosporine ≥98% | 1619994-69-2 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 14119 | Bromosporine ≥98% | 1619994-69-2 | 5mg | $119 | 2026-04-30 | Buy |
| Cayman Chemical | 14119 | Bromosporine ≥98% | 1619994-69-2 | 10mg | $215 | 2026-04-30 | Buy |
| Cayman Chemical | 14119 | Bromosporine ≥98% | 1619994-69-2 | 25mg | $389 | 2026-04-30 | Buy |
BroMosporine Chemical Properties,Uses,Production
Description
Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1Bromosporine was able to reactivate HIV-1 replication in different latency models.2
Uses
Bromosporine is a broad spectrum inhibitor for bromodomains.
in vivo
Bromosporine (100 mg/kg; i.p.; daily for 10 days) shows better antitumor activity than individual when co-treated with 5-FU (HY-90006)[1].
| Animal Model: | Female BALB/c nude mice (5-6 weeks; injected with 1×106cells/100μL of HT116cells)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; daily for 10 days |
| Result: | Exhibited better antitumor activity than individual Bromosporine or 5-FU (HY-90006) when co-treated with the two agent. |
target
bromodomain
IC 50
HIV-1
storage
Store at +4°C
Background
Bromosporine is a potent broad-spectrum bromodomain inhibitor. Bromodomain and extra-terminal protein family members BRD2, BRD3, BRD4, and BRDT associate with acetylated lysines on histones and transcription factors to regulate their function, and have emerged as targets for cancer therapy. Treatment with Bromosporine induced the expression of latent HIV-1 in primary CD4+ T cells by inhibiting BET activity, leading to improved viral clearance in conjunction with antiretroviral therapy.
References
[1] SARAH PICAUD. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia[J]. Science Advances, 2016, 2 10. DOI:10.1126/sciadv.1600760
[2] HANYU PAN. The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.[J]. Oncotarget, 2017: 94104-94116. DOI:10.18632/oncotarget.21585
BroMosporine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +86-519-85525359 +86-15995072465 | sales@xuanmingchem.com | China | 912 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28509 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9796 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
View Lastest Price from BroMosporine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Bromosporine
1619994-69-2
|
$39.00-143.00 | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | BroMosporine
1619994-69-2
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Bromosporine
1619994-69-2
- $39.00-143.00
- 99.79%
- TargetMol Chemicals Inc.
-
- BroMosporine
1619994-69-2
- $1.00
- 98%
- Career Henan Chemical Co
